Elevated Plasma Pentraxin 3 and Its Association with Retinal Vein Occlusion

Park, Kyong Soo; Kim, Ji Wan; An, Jae Hwan; Woo, Je Moon

doi:10.3341/kjo.2014.28.6.460

Cited by 7 publications

(6 citation statements)

References 32 publications

(35 reference statements)

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“…Therefore, the level of PTX3 may be more directly responsive to the inflammatory state. 32,34 Previous studies found that PTX3 participates in inflammatory, regulates the distribution of white blood cells and improves the permeability of blood vessels by binding to different ligands such as growth factors, extracellular matrix components, complement cascade molecules, pathogen recognition proteins, angiogenesis and adhesion molecules. 35 In addition, it was reported that PTX3 can inhibit growth and invasion of tumor cells by blocking Akt and NF-κB signaling pathway, but the mechanism was still unclear.…”

Section: Physiological Functions and Mechanisms Of Tnfaip5mentioning

confidence: 99%

<p>Tumor Necrosis Factor Alpha-Induced Proteins in Malignant Tumors: Progress and Prospects</p>

Guo¹,

Yuan²

2020

OTT

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Tumor necrosis factor (TNF) is the first cytokine used in tumor biotherapy, but TNFrelated drugs are limited by the lack of specific targets. Tumor necrosis factor alpha-induced proteins (TNFAIPs), derived from TNF, is a protein family and participates in proliferation, invasion and metastasis of tumor cells. In order to better understand biological functions and potential roles of TNFAIPs in malignant tumors, this paper in the form of "Gene-Protein-Tumor correlation" summarizes the biological characteristics, physiological functions and mechanisms of TNFAIPs by searching National Center of Biotechnology Information, GeneCards, UniProt and STRING databases. The relationship between TNFAIPs and malignant tumors is analyzed, and protein-protein interaction diagram in members of TNFAIPs is drawn based on TNF for the first time. We find that TNF as a key factor is related to TNFAIP1, TNFAIP3, TNFAIP5, TNFAIP6, TNFAIP8 and TNFAIP9, which can be directly involved in activating TNFAIP1, TNFAIP5, TNFAIP8 and TNFAIP9. We confirm that the mechanism of TNFAIP1, TNFAIP2 and TNFAIP3 inducing tumors may be related to NF-κB signaling pathway, but the mechanism of tumor induction by other members of TNFAIPs is not clear. In the future, translational studies are needed to explore the mechanisms of TNF-TNFAIPs-tumors.

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Section: Physiological Functions and Mechanisms Of Tnfaip5mentioning

confidence: 99%

<p>Tumor Necrosis Factor Alpha-Induced Proteins in Malignant Tumors: Progress and Prospects</p>

Guo¹,

Yuan²

2020

OTT

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“…PTX3 has been evaluated also in the retinal vein occlusion (RVO), the second most common retinal vascular disease after diabetic retinopathy. This study demonstrate that PTX3 could be used as a useful diagnostic biomarker since patients with RVO have high plasma level of PTX3 [ 70 ]. Finally, during 2016 Zhou and Hu suggest that the use of PTX3 could be used as an anti-angiogenic molecule because PTX3 interacts specifically with FGF2 factor reducing the proliferative diabetic retinopathy thus ameliorating DR condition [ 68 ].…”

Section: Ptx3 In Cardiovascular Diseasesmentioning

confidence: 99%

The inflammatory protein Pentraxin 3 in cardiovascular disease

et al. 2016

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The acute phase protein Pentraxin 3 (PTX3) plays a non-redundant role as a soluble pattern recognition receptor for selected pathogens and it represents a rapid biomarker for primary local activation of innate immunity and inflammation. Recent evidence indicates that PTX3 exerts an important role in modulating the cardiovascular system in humans and experimental models. In particular, there are conflicting points concerning the effects of PTX3 in cardiovascular diseases (CVD) since several observations indicate a cardiovascular protective effect of PTX3 while others speculate that the increased plasma levels of PTX3 in subjects with CVD correlate with disease severity and with poor prognosis in elderly patients.In the present review, we discuss the multifaceted effects of PTX3 on the cardiovascular system focusing on its involvement in atherosclerosis, endothelial function, hypertension, myocardial infarction and angiogenesis. This may help to explain how the specific modulation of PTX3 such as the use of different dosing, time, and target organs could help to contain different vascular diseases. These opposite actions of PTX3 will be emphasized concerning the modulation of cardiovascular system where potential therapeutic implications of PTX3 in humans are discussed.

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“…Furthermore, disorders such as deficiency of Protein C and S, deficiency of antithrombin III, or a genetic mutation in prothrombin gene, antiphospholipid antibodies and hyperhomocysteinemia are other possible pathophysiologic mechanisms of BRVO. 5 A multitude of risk factors have been considered in BRVOs, including diabetes mellitus, atherosclerotic disease, hypertension, open angle glaucoma, connective tissue pathologies, P J M H S Vol. 15, NO.9, SEP 2021 2365 thrombophilia and other causes of hyper-coagulability.…”

Section: Discussionmentioning

confidence: 99%

The Therapeutic Predicament of Branch Retinal Vein Occlusion in uncontrolled Hypertension in Pakistan

Riaz¹,

Mohydin²,

Mohsin³

et al. 2021

PJMHS

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Around the globe, hypertension is a silent pandemic. After diabetic retinopathies, hypertensive retinal vascular diseases are one of the most prevalent. In Pakistan, diagnostic investigations due to their cost are not done on regular screening basis as the financial burden of management is a point at issue. Thus, such conditions can often go undetected or therapeutically compromised. Here is a case of unilateral ischemic branch retinal vein occlusion in a 48-year-old male with a history of uncontrolled hypertension and diabetes. Additional laboratory investigations were carried out including complete lipid profile, serum urea and creatinine levels. Fundus fluorescein angiography and optical coherence tomography was done. The patient was managed on anti-VEGF injections and Argon Laser. Follow-up along with a multi-disciplinary management approach is essential for the best possible prognosis. Keywords: hypertension, central retinal vein occlusion (CRVO), branch retinal vein occlusion (BRVO)

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Elevated Plasma Pentraxin 3 and Its Association with Retinal Vein Occlusion

Cited by 7 publications

References 32 publications

<p>Tumor Necrosis Factor Alpha-Induced Proteins in Malignant Tumors: Progress and Prospects</p>

<p>Tumor Necrosis Factor Alpha-Induced Proteins in Malignant Tumors: Progress and Prospects</p>

The inflammatory protein Pentraxin 3 in cardiovascular disease

The Therapeutic Predicament of Branch Retinal Vein Occlusion in uncontrolled Hypertension in Pakistan

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