Elevated plasma matrix metalloproteinase-9 protein and its gene polymorphism in patients with community-acquired pneumonia

Chiang, Ting Yen; Shyu, Ling Yuh; Tsao, Thomas Chang Yao; Chien, Ming Hsien; Tsao, Shih Ming; Lee, Yuan Ti; Yang, Shun Fa

doi:10.1515/cclm.2011.805

Cited by 9 publications

(12 citation statements)

References 23 publications

(23 reference statements)

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“…We performed a zymographic analysis to determine active and inactive MMPs in the serums of CAP patients and controls. Active forms of MMP-2 and MMP-9 were 13 and 17 times higher, respectively, in CAP patients than controls, making our findings consistent with the results of previous studies (6,23,24,(26)(27)(28).…”

Section: Discussionsupporting

confidence: 92%

“…However, only a few studies in the literature have investigated the role of MMPs in pneumonia pathogenesis (6,(22)(23)(24)(26)(27)(28). These have shown that patients with hospital-acquired pneumonia (HAP) have excessive MMP-8 and -9 concentrations in plasma and mini-BAL fluids compared to healthy controls (22)(23)(24).…”

Section: Discussionmentioning

confidence: 99%

“…These have shown that patients with hospital-acquired pneumonia (HAP) have excessive MMP-8 and -9 concentrations in plasma and mini-BAL fluids compared to healthy controls (22)(23)(24). Excessive serum MMP-9 levels and MMP-9 activities have also been reported in the few studies of patients with CAP (6,(26)(27)(28). We performed a zymographic analysis to determine active and inactive MMPs in the serums of CAP patients and controls.…”

Section: Discussionmentioning

confidence: 99%

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Elevated serum matrix metalloproteinase-2 and -9 and their correlationswith severity of disease in patients with community-acquired pneumonia

Bircan¹,

Çakır²,

Kapulu³

et al. 2015

Turk J Med Sci

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Background/aim: To determine the role of matrix metalloproteinases (MMPs) and their relationship with the clinical course of community-acquired pneumonia (CAP).Materials and methods: Sixty-two consecutively hospitalized patients with CAP were enrolled and their pneumonia severity index (PSI), time to clinical stability (TCS), treatment response, and complications were recorded. The pre-and posttreatment serum concentrations of MMPs and their inhibitors were analyzed by ELISA. The activities of MMPs were evaluated by gelatin zymography.Results: MMP-2 and -9 serum levels and their activities were higher in CAP patients than controls (P < 0.001 and P < 0.001, respectively). Low-risk patients had lower levels of MMP-2 and TIMP-1 than high-risk patients (P = 0.044, P = 0.001, respectively). Pretreatment serum TIMP-1 level was higher in patients with TCS of >3 days (P = 0.004) and was correlated with oxygenation and PSI scores. Posttreatment serum levels of MMP-9 and TIMP-1 were decreased after antibiotics (P = 0.0001 and P = 0.017, respectively). Conclusion:Although MMP-2, MMP-9, and TIMP-1 correlate with many poor prognostic factors, more studies are required to prove their possible role in predicting the severity of CAP.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Elevated serum matrix metalloproteinase-2 and -9 and their correlationswith severity of disease in patients with community-acquired pneumonia

Bircan¹,

Çakır²,

Kapulu³

et al. 2015

Turk J Med Sci

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“…Community-acquired pneumonia (CAP) describes one of several diseases in which people who have not recently been hospitalized develop an infection of the lungs. CAP may be caused by bacterial, viral, fungal, or parasite agents with the complication of upper respiratory tract infection [1]. Moreover, CAP is the most frequently occurring infectious disease in the world, with high morbidity and mortality rates.…”

Section: Introductionmentioning

confidence: 99%

Usefulness of Plasma YKL-40 in Management of Community-Acquired Pneumonia Severity in Patients

Wang

Hsiao

Tsai

et al. 2013

IJMS

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Plasma YKL-40 level has been reported as playing a significant role in community-acquired pneumonia (CAP). However, the correlation between plasma level of YKL-40 and the severity of CAP has not been reported. This study identifies the relationship between plasma level changes of the YKL-40 gene in adult patients hospitalized with CAP. The ELISA was used to measure the plasma YKL-40 level from 61 adult CAP patients before and after antibiotic treatment and from 60 healthy controls. The plasma YKL-40 levels were significantly increased in patients with CAP compared to normal controls. Moreover, the plasma concentration of YKL-40 correlated with the severity of CAP based on the pneumonia severity index (PSI) score (r = 0.630, p < 0.001), the CURB-65 (confusion, uremia, respiratory rate, BP, age 65 years) score (r = 0.640, p < 0.001), the Acute Physiology And Chronic Health Evaluation II (APACHE II) score (r = 0.539, p < 0.001) and length of hospital stay (r = 0.321, p = 0.011), respectively. In conclusion, plasma YKL-40 may play a role in the diagnosis and clinical assessment of CAP severity, which could potentially guide the development of treatment strategies.

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“…Community-acquired pneumonia (CAP) is one of several diseases that results in lung infections in individuals who have not recently been hospitalized. CAP may be caused by bacterial, viral, fungal or parasitic agents with the additional complication of upper respiratory tract infections (1,2). Furthermore, CAP is the most frequently occurring infectious disease worldwide, with high morbidity and mortality rates (3).…”

Section: Introductionmentioning

confidence: 99%

Plasma levels of soluble Axl correlate with severity of community-acquired pneumonia

Hsiao

et al. 2014

Molecular Medicine Reports

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Abstract. The aim of this study was to examine the plasma level changes of soluble Axl (sAxl) prior to and following treatment with antibiotics in hospitalized adult patients with community-acquired pneumonia (CAP), and to investigate the correlating clinical and laboratory manifestations of CAP with plasma sAxl levels. Blood samples were obtained from 61 adult CAP patients (prior to and following treatment with antibiotics) and 60 healthy controls in order to measure the plasma concentrations of sAxl using the enzyme-linked immunosorbent assay. The plasma-soluble Axl concentration level was markedly elevated in patients with CAP prior to treatment, compared with the controls, and decreased markedly following treatment. The levels of white blood cells, neutrophils, and C-reactive protein decreased markedly following treatment with antibiotics and did not correlate with the concentration level of sAxl. However, the plasma concentration of sAxl correlated with the severity of CAP with the pneumonia severity index score (r=0.350, P=0.006, n=61), the CURB-65 score (r=0.281, P=0.028, n=61) and the acute physiology and chronic health evaluation II score (r=0.313, P=0.014, n=61). In conclusion, plasma sAxl may be involved in the clinical assessment of the severity of CAP, which may guide the development of treatment strategies and predict the clinical outcome.

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Elevated plasma matrix metalloproteinase-9 protein and its gene polymorphism in patients with community-acquired pneumonia

Abstract: Elevated plasma MMP-9 could be a biological marker for the diagnosis and be a new strategy for target therapy of community-acquired pneumonia.

Cited by 9 publications

References 23 publications

Elevated serum matrix metalloproteinase-2 and -9 and their correlationswith severity of disease in patients with community-acquired pneumonia

Elevated serum matrix metalloproteinase-2 and -9 and their correlationswith severity of disease in patients with community-acquired pneumonia

Usefulness of Plasma YKL-40 in Management of Community-Acquired Pneumonia Severity in Patients

Plasma levels of soluble Axl correlate with severity of community-acquired pneumonia

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