2020
DOI: 10.1111/ene.14430
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Elevated plasma high‐sensitivity C‐reactive protein at admission predicts the occurrence of post‐stroke fatigue at 6 months after ischaemic stroke

Abstract: Background and purpose Post‐stroke fatigue (PSF) is a common neuropsychiatric affective symptom occurring after stroke. Evidence indicates activated inflammatory pathways are involved in modulating the stroke and fatigue. High‐sensitivity C‐reactive protein (hs‐CRP) is one of the most sensitive indicators of inflammation. Our aim was to estimate the association between plasma hs‐CRP and PSF after acute ischaemic stroke. Methods In all, 212 acute ischaemic stroke patients were consecutively recruited within the… Show more

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Cited by 18 publications
(7 citation statements)
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“…Hs-CRP has been used to predict the prognosis of cardiovascular [17] and cerebrovascular disorders [18]. A previous study also suggested that PSF 6 months after a stroke was linked to elevated plasma hs-CRP levels upon admission, and this outcome is in line with the findings of the present study [19]. Another inflammatory marker, PLR, has been recently gaining attention as an indicator that reflects the inflammatory state of the body, and is also used as a prognostic predictor in cancer patients [20][21][22], cardiovascular disease patients [23,24], stroke patients [25], and coronavirus disease-19 (COVID-19) patients.…”
Section: Discussionsupporting
confidence: 91%
“…Hs-CRP has been used to predict the prognosis of cardiovascular [17] and cerebrovascular disorders [18]. A previous study also suggested that PSF 6 months after a stroke was linked to elevated plasma hs-CRP levels upon admission, and this outcome is in line with the findings of the present study [19]. Another inflammatory marker, PLR, has been recently gaining attention as an indicator that reflects the inflammatory state of the body, and is also used as a prognostic predictor in cancer patients [20][21][22], cardiovascular disease patients [23,24], stroke patients [25], and coronavirus disease-19 (COVID-19) patients.…”
Section: Discussionsupporting
confidence: 91%
“…Pro-in ammatory cytokine, might be involved in the pathophysiology of sICH after endovascular treatment through in ammatory responses, may be induced by high sensitivity C-reactive protein. In addition, several clinical studies also found that high-sensitivity Creactive protein is associated with progressive stroke [9] and post-stroke fatigue [37] . Moreover, it is believed that albumin, a heart-shaped plasma protein with a 585 amino acid polypeptide chain, possesses neuroprotective effect, and serum albumin levels are likely lower in in ammatory states [38] .…”
Section: Discussionmentioning
confidence: 98%
“…Moreover, a meta-analysis demonstrated that elevated CRP is associated with the increased possibility of all-cause mortality in acute ischemic stroke subjects. Another study concluded that abnormal CRP may be linked to the stenosis of some cerebral arteries, and also, elevated hsCRP can possibly predict post-stroke disability, apathy, delirium, fatigue, cognitive impairment, and depression [550][551][552][553][554][555][556][557]. However, it was noted that the importance of CRP in ischemic stroke maybe less in older adults than in middle-aged populations, whereas the rapid post-stroke or post-MI hsCRP measurements showing an acute increase are not reflective of pre-stroke levels and may be less reliable for long-term risk stratification [77].…”
Section: Neurological Disordersmentioning
confidence: 99%