Elevated p21 expression is associated with poor prognosis of rectal stromal tumors after resection

Hu, Tsung–Hui; Tai, Ming‐Hong; Chuah, Seng‐Kee; Chen, Hong‐Hwa; Lin, Jui-Wei; Huang, Hsuan‐Ying; Chou, Yeh‐Pin; Yi, Li-Na; Kuo, Chien-Lin; Changchien, Chi‐Sin

doi:10.1002/jso.21094

Cited by 14 publications

(10 citation statements)

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“…The results showed that the expression of p21 (P=0.0222) and p27 (P=0.2777) negatively correlated with prognosis, however, this was not statistically significant for p27. The present study demonstrated that the five-year survival rate of patients with a p21 expression score of >2.7 was significantly lower when compared with that of patients with a score of ≤2.7, inconsistent with the majority of previous studies in OSCC (10,11) and other types of cancer (29–34). However, certain other controversial results have also been reported (35–37).…”

Section: Discussioncontrasting

confidence: 99%

Prognostic significance of p21, p27 and survivin protein expression in patients with oral squamous cell carcinoma

et al. 2013

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Oral squamous cell carcinoma (OSCC) accounts for >80% of head and neck malignancies. p21, p27 and survivin proteins are abnormally expressed in OSCC and have been previously reported to correlate with cell proliferation and apoptosis. However, the prognostic significance of p21, p27 and survivin remains controversial. The aim of the present study was to investigate the association of clinical parameters and prognosis with the levels of p21, p27 and survivin expression in patients with OSCC. The levels of the three biomarkers were evaluated by immunohistochemical staining in specimens from 110 patients with OSCC and each section was scored according to the percentage of positive tumor cells and staining intensity. Log-rank test and Cox proportional hazards regression were performed to assess the correlation between biomarkers and clinical events. The association between the immunoexpression of p21, p27 and survivin and clinical pathological variables were analyzed by the χ2 test and a non-parametric analysis. The expression of p21 in patients with OSCC was found to correlate with the expression of p27 and survivin. The results of the current study revealed that the five-year survival rate was significantly lower in patients with high p21 expression. In addition, the expression of p27 also showed a negative correlation with the five-year survival rate of OSCC, but to a lesser extent. By contrast, the expression of survivin was not a prognostic factor for OSCC. A Kaplan-Meier analysis and Cox proportional hazards model showed that lymph node metastasis and p21 expression were independent prognostic factors of OSCC.

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Section: Discussioncontrasting

confidence: 99%

Prognostic significance of p21, p27 and survivin protein expression in patients with oral squamous cell carcinoma

et al. 2013

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“…For example, elevated p21 expression correlated with diminished survival of esophageal squamous cell carcinoma patients with mutations in the p53 gene [33]. Correspondingly, p21 expression was also associated with poor prognosis of patients with rectal stromal tumors after resection [34] and induction of p21 during anticancer treatment in patients with rectal carcinoma was correlated with the development of resistance to neoadjuvant radiochemotherapy, with worse outcome of the disease [35].…”

Section: P21 As An Oncogenementioning

confidence: 99%

p21^WAF1/CIP1 and cancer: A shifting paradigm?

Gartel

2009

BioFactors

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The cyclin-dependent kinase inhibitor p21(WAF1/CIP1) is a key mediator of p53-dependent cell cycle arrest and may play the role of a tumor suppressor in cancer. However, it has been shown that p21 may also act as an oncogene, because it inhibits apoptosis and may promote cell proliferation in some tumors. These data point out to "antagonistic duality" of p21, because it possesses anticancer and procancer properties at the same time. New data suggest that more and more proteins also may play contradictory roles in cancer thus challenging current paradigm of established oncogenes and tumor suppressors. (c) 2009 International Union of Biochemistry and Molecular Biology, Inc.

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“…Finally, 14 articles published from 1995 to 2017 with 1372 patients is in line with the criteria for meta-analysis. [8–14,23–29] The detailed process of study selection is presented as a flowchart in Fig. 1.…”

Section: Resultsmentioning

confidence: 99%

The prognostic value of proliferating cell nuclear antigen expression in colorectal cancer

Zhou¹,

Huang

Xiong

et al. 2018

Medicine

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Background:A number of studies have attempted to determine the prognostic significance of proliferating cell nuclear antigen (PCNA) in patients with colorectal cancer (CRC), but the reports are controversial and inconsistent. Thus, we conducted a meta-analysis to clarify the value of PCNA in CRC prognosis.Methods:A systematic search of relevant studies was performed in 4 electronic databases including PubMed, Cochrane Library, Embase, and Web of Science until February 2018. Hazard ratios (HRs) combined with 95% confidence intervals (95% CIs) were used to evaluate the relationship of PCNA expression with overall survival (OS), cancer-specific survival (CSS), and disease-free survival (DFS).Results:A total of 1372 CRC patients in 14 studies were identified eventually in our meta-analysis. The pooled HRs demonstrated that CRC patients with high PCNA expression was significantly correlated with poor OS (HR = 1.81; 95% CI: 1.51–2.17; P = .000), CSS (HR = 1.99; 95% CI: 1.04–3.79; P = .037); but not significantly with DFS (HR = 2.48; 95% CI: 0.98–6.26; P = .055). Sensitivity analysis showed the pooled HRs for OS, CSS, and DFS were stable when the included studies were removed one by one.Conclusion:Our meta-analysis suggested that high PCNA expression was associated with poor prognosis, and it could serve as a reliable and prognostic biomarker in CRC patients. More large-scale studies are needed to further support the conclusion.

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Elevated p21 expression is associated with poor prognosis of rectal stromal tumors after resection

Abstract: Elevated p21 expression is associated with poor prognosis of rectal stromal tumors after resection.

Cited by 14 publications

References 34 publications

Prognostic significance of p21, p27 and survivin protein expression in patients with oral squamous cell carcinoma

Prognostic significance of p21, p27 and survivin protein expression in patients with oral squamous cell carcinoma

p21^WAF1/CIP1 and cancer: A shifting paradigm?

The prognostic value of proliferating cell nuclear antigen expression in colorectal cancer

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Elevated p21 expression is associated with poor prognosis of rectal stromal tumors after resection

Abstract: Elevated p21 expression is associated with poor prognosis of rectal stromal tumors after resection.

Cited by 14 publications

References 34 publications

Prognostic significance of p21, p27 and survivin protein expression in patients with oral squamous cell carcinoma

Prognostic significance of p21, p27 and survivin protein expression in patients with oral squamous cell carcinoma

p21WAF1/CIP1 and cancer: A shifting paradigm?

The prognostic value of proliferating cell nuclear antigen expression in colorectal cancer

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Resources

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p21^WAF1/CIP1 and cancer: A shifting paradigm?