Abstract:HIV infection is associated with left ventricular (LV) dysfunction and accelerated atherosclerosis. These conditions result in elevation of plasma natriuretic peptide (NP) levels. The present study compares N-terminal-pro-BNP (NT-pro-BNP) levels in HIV-infected and -uninfected women and identifies factors influencing NT-pro-BNP levels in HIV-infected women. A total of 454 HIV-infected and 200 HIV-uninfected participants from the Women’s Interagency HIV Study (WIHS) had NT-pro-BNP determination. Elevated NT-pro… Show more
“…Elevated NT-proBNP levels are associated with comorbidities that include chronic renal failure, type 2 diabetes, anemia, and acute coronary syndrome [28,29]. In this study, the most frequent comorbidity was diabetes, and patients in the Low group (NT-proBNP < 380 mg/mL) were less likely to have comorbidities compared with the patients in the High group.…”
ly leads to hospitalization and high treatment costs which are more than 800 billion won per year [4].Patients with heart failure experience physical symptoms, including fatigue, dyspnea, and generalized edema, depending on the condition's severity. These physical symptoms can have psychological effects, for example, anxiety, depression, and reduced self-efficacy, which can hinder daily activities, work, and a person's social life [6]. Heart failure is difficult to cure, and its characteristics often include recurrent cycles of deterioration and improvement. Consequently, rehospitalization rates con- Purpose: This study aimed to examine the relationships between the N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels with the sociodemographic and clinical factors, self-care behaviors, and the physical symptom experiences in patients with heart failure. Methods: This cross-sectional study utilized a convenience sample of adult outpatients and inpatients who attended a cardiology department in a tertiary hospital in Seoul, Korea. The data from 154 patients with heart failure were collected using a questionnaire, and their clinical data were extracted from their electronic medical records. Results: Compared with the patients with high NTproBNP levels, those with low NT-proBNP levels had significantly lower physical symptom experiences scores. Patients with low-and mid-NT-proBNP levels were more likely to be employed compared with those with high NT-proBNP levels. Patients with low NT-proB-NP levels had higher left ventricular ejection fractions, and were less likely to have arrhythmias and comorbidities. Conclusion: The results from this study showed that patients with more severe heart failure had higher physical symptom experiences scores; hence, individualizing treatment approaches based on heart failure severity is necessary. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
“…Elevated NT-proBNP levels are associated with comorbidities that include chronic renal failure, type 2 diabetes, anemia, and acute coronary syndrome [28,29]. In this study, the most frequent comorbidity was diabetes, and patients in the Low group (NT-proBNP < 380 mg/mL) were less likely to have comorbidities compared with the patients in the High group.…”
ly leads to hospitalization and high treatment costs which are more than 800 billion won per year [4].Patients with heart failure experience physical symptoms, including fatigue, dyspnea, and generalized edema, depending on the condition's severity. These physical symptoms can have psychological effects, for example, anxiety, depression, and reduced self-efficacy, which can hinder daily activities, work, and a person's social life [6]. Heart failure is difficult to cure, and its characteristics often include recurrent cycles of deterioration and improvement. Consequently, rehospitalization rates con- Purpose: This study aimed to examine the relationships between the N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels with the sociodemographic and clinical factors, self-care behaviors, and the physical symptom experiences in patients with heart failure. Methods: This cross-sectional study utilized a convenience sample of adult outpatients and inpatients who attended a cardiology department in a tertiary hospital in Seoul, Korea. The data from 154 patients with heart failure were collected using a questionnaire, and their clinical data were extracted from their electronic medical records. Results: Compared with the patients with high NTproBNP levels, those with low NT-proBNP levels had significantly lower physical symptom experiences scores. Patients with low-and mid-NT-proBNP levels were more likely to be employed compared with those with high NT-proBNP levels. Patients with low NT-proB-NP levels had higher left ventricular ejection fractions, and were less likely to have arrhythmias and comorbidities. Conclusion: The results from this study showed that patients with more severe heart failure had higher physical symptom experiences scores; hence, individualizing treatment approaches based on heart failure severity is necessary. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
“…In the study by Mansoor [16], NTproBNP levels in the general population were found to be associated with the presence of anaemia and renal dysfunction. In the case of women infected with HIV, no relation with the use of HAART was found.…”
Section: Discussionmentioning
confidence: 93%
“…The patients were part of a previous research series [16] created to study the left ventricular mass in patients with HIV infection. The patients in this serie who were aged over 40 years were invited to cooperate in the present study, to determine levels of NT-proBNP in peripheral blood.…”
Section: Methodsmentioning
confidence: 99%
“…However, few studies have focused on determining levels of NT-proBNP in patients with HIV infection, relating them to increased systolic pressure in the pulmonary artery [15] and the presence of comorbidities [16]. There is also some evidence that ART could be involved in increased left ventricular mass, and thus an analysis of these biomarkers could provide an additional prognostic measure for our patients [17].…”
Objective: To determine the levels of NT-pro BNP in HIV patients over 40 years who are receiving highly active antiretroviral therapy (HAART) and investigating potential independent clinical or laboratory factors. Method: We determine levels of NT-pro BNP in peripheral blood of HIV patients from Costa del Sol Hospital, over 40 years. We collected epidemiological, classical cardiovascular risk factors and variables associated with HIV infection status. The qualitative variables were compared using the χ2 test. NT-proBNP levels were taken as the dependent variable. The association between these levels and the quantitative variables were studied by analysis of variance (ANOVA), and the association with the qualitative variables, using Student's t test. Results: Nt-pro BNP levels were determined in 146 HIV patients. We assess the 10-year cardiovascular risk calculated by the Framingham equation, 59 (41.5%) were classified as low risk, 46 (32.4%) as a moderate risk and 37 (26.1%) as a high risk. The higher levels of NT-pro BNP were found in women, and in those patient with lower filtration rate and high levels of triglycerides. An association was also observed between higher levels of NT-proBNP and the recent use of lamivudine and fosamprenavir. After a multivariate analysis we found an association between higher levels of NT-proBNP and the current use of fosamprenavir and a lower glomerular filtration rate. Conclusions: We found, with the limitations of a small serie, that higher levels of NTproBNP in HIV patients could be linked to the occurrence of cardiovascular events, this fact suggest that NTpro BNP could be used in patients at moderate or high vascular risk in order to optimise the primary prevention of vascular events.
“…Starting from a very early study, it is shown that despite restoration to the normovolemia, BNP levels were not reduced to their normal levels [38]. Other studies showed that, aside cardiovascular conditions, BNP levels can also be affected by some neurologic conditions like hemorrhagic stroke [39] and ischemic stroke [40], by critical illnesses like sepsis [41,42] and HIV [43], by some pulmonary diseases like pulmonary hypertension [44,45] and pulmonary embolism [46,47]; or by some other conditions like anemia [48,49], cirrhosis [50], and hypertension [51]. Moreover, in hemodialysis patients, the levels of natriuretic peptides also seem to be related to the dialytic membranes.…”
Volume overload is an important, may be the foremost, independent prognostic factor determining the outcome of hemodialysis patients. Therefore, it is crucial to measure fluid status of these patients and avoid volume overload. This review aims to evaluate volume overload, its effects on patients with renal diseases and current methodologies measuring volume status in the body. These techniques will be first classified as clinical evaluation and non-clinical and/or instrumental techniques, which includes biomarkers, ultrasonography, relative blood volume monitoring, bioimpedance, echocardiography, pulmonary artery catheterization, esophageal and/or suprasternal Doppler, and blood viscosity. Advantages and limitations of these different techniques will be reviewed extensively by comparing each other. At last, insights gained from this review can highlight the future prospects in this active area of research.
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