Elevated neutrophil‑to‑lymphocyte ratio is associated with nutritional impairment, immune suppression, resistance to S‑1 plus cisplatin, and poor prognosis in patients with stage?IV gastric cancer

Gonda, Kenji; Shibata, Masahiko; Sato, Yu; Washio, Marie; Takeshita, Hideki; Shigeta, Hirofumi; Ogura, Michikazu; Oka, Shinichi; Sakuramoto, Shinich

doi:10.3892/mco.2017.1438

Cited by 28 publications

(37 citation statements)

References 33 publications

(36 reference statements)

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“…A new prognostic index in recent years was proposed with FAR for patients with ESCC 17 . PALB, as another important nutritional indicator, is more sensitive to malnutrition than ALB 18,19 . However, no study regarding the prognostic role of FPR has been assessed so far in ESCC patients.…”

Section: Discussionmentioning

confidence: 99%

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A Novel Prognostic Index in Patients with Resectable Esophageal Squamous Cell Carcinoma: Fibrinogen/Prealbumin Ratio

Feng¹,

Wang²,

Jiang³

et al. 2020

RIC

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Background: Fibrinogen (Fib) to albumin (ALB) fibrinogen-to-albumin ratio as a prognostic index for esophageal cancer has been confirmed. A novel prognostic index was initially proposed with fibrinogen to prealbumin ratio (FPR) in patients with resectable esophageal squamous cell carcinoma (ESCC). Objective: The objective of the study was to study the prognostic role of the novel prognostic index (FPR) in patients with resectable ESCC without any neoadjuvant treatment. Methods: In this retrospective study, a total of 372 resectable ESCC patients without any neoadjuvant treatment were included. The best cutoff values were selected by the receiver operating characteristic curves. Two Cox regression analyses with forward stepwise (one for categorical variables and the other for continuous variables) were used to evaluate the overall survival (OS) and cancer-specific survival (CSS). Results: The best cutoff point was 0.014 for FPR. Patients with lower levels of FPR (≤0.014) had better CSS (50.7% vs. 18.0%, p < 0.001) and OS (48.0% vs. 17.6%, p < 0.001) than patients with higher levels of FPR (> 0.014). Multivariate Cox analyses (categorical and continuous) demonstrated that FPR was an independent prognostic factor in CSS (cat

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Section: Discussionmentioning

confidence: 99%

“…Prealbumin (PALB) is another important factor for nutritional status, which is more sensitive to malnutrition than ALB 18,19 . According to the above theoretical basis; therefore, we hypothesized that PALB could substitute for ALB to combine with Fib to construct a new index: fibrinogen to prealbumin ratio (FPR).…”

Section: Introductionmentioning

confidence: 99%

A Novel Prognostic Index in Patients with Resectable Esophageal Squamous Cell Carcinoma: Fibrinogen/Prealbumin Ratio

Feng¹,

Wang²,

Jiang³

et al. 2020

RIC

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“…Several studies have shown that prealbumin has a short half-life and can be used as a parameter in nutritional status evaluation with demonstrated superiority to albumin. [18][19][20][21] Prealbumin is also associated with postoperative recovery and is an independent predictor of prognosis in patients with malignancies. 22,23 Recently, the preoperative CRP/prealbumin ratio (CRP/PAlb ratio) was reported to have a better predictive value for the recurrence of gastric cancer than traditional inflammatory indices.…”

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confidence: 99%

Prognostic Significance of C-reactive Protein-to-prealbumin Ratio in Patients with Esophageal Cancer

et al. 2020

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Background The prognostic value of combination of C-reactive protein and prealbumin (CRP/PAlb) in esophageal cancer remains unclear. Methods We enrolled 167 esophageal cancer patients who underwent curative esophagectomy. Univariate and multivariate analyses were performed to determine the prognostic significance of various markers, including CRP-to-albumin (CRP/Alb) ratio, modified Glasgow prognostic score, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and prognostic nutritional index. Results Receiver operating characteristic analysis revealed the optimal cut-off value of each inflammatory factor, and CRP/PAlb ratio had the greatest discriminative power in predicting recurrence-free survival (RFS) among the examined measures (AUC 0.668). The 5-year overall survival and RFS rates were significantly lower in patients with high CRP/PAlb ratio than in those with low CRP/PAlb ratio (P < 0.001, P = 0.001, respectively). In the univariate analysis, RFS was significantly worse in patients with low BMI, T2 or deeper tumor invasion, positive lymph node metastasis, positive venous invasion, high CRP/PAlb ratio, high CRP/Alb ratio, high NLR, and high LMR. Multivariate analysis revealed that CRP/PAlb, but not CRP/Alb, was an independent prognostic factor along with lymph node metastasis. Conclusion CRP/PAlb ratio was useful for predicting the prognosis of esophageal cancer patients.

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“…Among these, NLR is most well known as a marker of poor prognosis in DFS or OS for various malignant tumours, as well as for poor response to chemotherapy or radiotherapy and IL‐2 immunotherapy response in renal cell carcinoma. Cancer‐related systemic inflammation has been correlated with the characteristics of advanced and more aggressive tumour types, including larger tumour size and poorer tumour differentiation …”

Section: Discussionmentioning

confidence: 99%

Prognostic impact of the combination of the neutrophil‐to‐lymphocyte ratio and serum carbohydrate antigen 19‐9 in patients with pancreas head cancer

Kim

Lim

Park

et al. 2019

ANZ Journal of Surgery

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Background This study aimed to evaluate the clinical value of the combination of a traditional prognostic factor with a systemic inflammation‐based prognostic factor in patients undergoing curative resection for pancreas head cancer diagnosed as pancreatic ductal adenocarcinoma. Methods From January 2005 to December 2015, 198 patients were enrolled. Various clinicopathological factors potentially associated with survival and recurrence were evaluated in this study. Results The selected cut‐off values for the test prognostic factors with sufficient sensitivity and specificity were 2.8 for the neutrophil‐to‐lymphocyte ratio (NLR) and 70 U/mL for serum carbohydrate antigen 19‐9 (CA19‐9). Kaplan–Meier survival analysis demonstrated that the 5‐year survival rate in patients with a high NLR and CA19‐9 was 21.8% compared with 79.8% for patients with a low NLR and CA19‐9. The 5‐year disease‐free survival rate in patients with a high NLR and CA19‐9 was 0% compared with 33.9% for patients with a low NLR and CA19‐9. Patients with high NLRs and high CA19‐9 were more likely to have an early recurrence and multiple relapse patterns. Conclusion Preoperative NLR and serum CA19‐9 offer significant prognostic information for survival following curative resection of pancreas head cancer diagnosed as pancreatic ductal adenocarcinoma.

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Elevated neutrophil‑to‑lymphocyte ratio is associated with nutritional impairment, immune suppression, resistance to S‑1 plus cisplatin, and poor prognosis in patients with stage?IV gastric cancer

Cited by 28 publications

References 33 publications

A Novel Prognostic Index in Patients with Resectable Esophageal Squamous Cell Carcinoma: Fibrinogen/Prealbumin Ratio

A Novel Prognostic Index in Patients with Resectable Esophageal Squamous Cell Carcinoma: Fibrinogen/Prealbumin Ratio

Prognostic Significance of C-reactive Protein-to-prealbumin Ratio in Patients with Esophageal Cancer

Prognostic impact of the combination of the neutrophil‐to‐lymphocyte ratio and serum carbohydrate antigen 19‐9 in patients with pancreas head cancer

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