Elevated neutrophil to lymphocyte ratio might predict poor prognosis for colorectal liver metastasis after percutaneous radiofrequency ablation

Zhang, Yaojun; Peng, Zhenwei; Chen, Meixian; Liu, Furong; Huang, Junting; Xu, Li; Zhang, Yaqi; Chen, Minshan

doi:10.3109/02656736.2011.654374

Cited by 31 publications

(29 citation statements)

References 33 publications

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“…Halazun et al 15 have suggested 2 potential mechanisms through which a high NLR may be associated with poorer outcome: first, patients with an elevated NLR are relatively lymphocytopenic, resulting in a poorer lymphocyte-mediated immune response to malignancy and therefore an increased potential for tumor recurrence 16 ; second, a relatively high neutrophil count may aid in the development and progression of a neoplasm through release of vascular endothelial growth factor, a proangiogenic factor thought to be integral to tumor development. 18 This study provides some evidence to challenge the NLR threshold of 5 that has been recommended by several groups, [5][6][7][8][9][10] which was originally extrapolated from a Slovakian study of critically ill patients that showed an NLR of greater than 5 was associated with a poorer outcome. Longer follow-up may identify differences in OS between NLR groups.…”

Section: Discussionmentioning

confidence: 91%

“…5 The second group includes patients with metastatic liver disease where a value greater than 5 has been associated with poorer overall survival (OS) in patients undergoing both liver resection with chemotherapy and chemotherapy alone. 7 Finally, the third area where the use of preoperative NLR has been proposed is as a predictor of recurrence in patients undergoing curative surgery for CRC with no known metastases, where values of above 3 or 5 have been associated with poorer OS and disease-free survival (DFS). 7 Finally, the third area where the use of preoperative NLR has been proposed is as a predictor of recurrence in patients undergoing curative surgery for CRC with no known metastases, where values of above 3 or 5 have been associated with poorer OS and disease-free survival (DFS).…”

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confidence: 99%

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A Preoperative Neutrophil to Lymphocyte Ratio of 3 Predicts Disease-Free Survival After Curative Elective Colorectal Cancer Surgery

et al. 2014

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For patients with colorectal cancer, a preoperative NLR of more than 3.0 may be an independent prognostic factor for disease-free survival. Considering this in addition to well-established prognostic variables may improve the processes of identifying patients at higher risk of recurrence who would benefit from adjuvant therapies or more frequent surveillance, thereby providing more personalized cancer care.

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Section: Discussionmentioning

confidence: 91%

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confidence: 99%

A Preoperative Neutrophil to Lymphocyte Ratio of 3 Predicts Disease-Free Survival After Curative Elective Colorectal Cancer Surgery

et al. 2014

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“…An elevated NLR was recognized as an independent poor prognostic factor for various malignancies [22], [25], [26], [28], [29]. In the “NLR”, “N” represents the number of circulating neutrophils, and it could represent the levels of circulating angiogenesis-regulating chemokines, growth factors and proteases which are major contributors to tumor related angiogenesis [30], [31], [32].…”

Section: Discussionmentioning

confidence: 99%

Postoperative Neutrophil-to-Lymphocyte Ratio Change Predicts Survival of Patients with Small Hepatocellular Carcinoma Undergoing Radiofrequency Ablation

et al. 2013

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BackgroundAn elevated preoperative neutrophil-to-lymphocyte ratio (NLR) has been reported to be a prognostic factor for hepatocellular carcinoma (HCC) patients after treatment. However, the clinical implication of postoperative NLR change remains unclear.Materials and MethodsFrom May 2005 to Aug 2008, a cohort of consecutive 178 small HCC patients treated with radiofrequency ablation (RFA) was retrospectively reviewed. The NLR was recorded within 3 days before and 1 month after RFA. Baseline characteristics, overall survival (OS) and recurrence free survival (RFS) were compared according to preoperative NLR and/or postoperative NLR change. Prognostic factors were assessed by multivariate analysis.ResultsCompared with preoperative NLR level, postoperative NLR decreased in 87 patients and increased in 91 patients after RFA. No significant differences were identified between two groups in commonly used clinic-pathologic features. The 1, 3, 5 years OS was 98.8%, 78.6%, 67.1% for NLR decreased group, and 92.2%, 55.5%, 35.4% for NLR increased group respectively (P<0.001); the corresponding RFS was 94.2%, 65.2%, 33.8% and 81.7%, 46.1%, 12.4% respectively (P<0.001). In subgroup analysis, the survival of patients with lower or higher preoperative NLR can be distinguished more accurate by postoperative NLR change. Multivariate analysis showed that postoperative NLR change, but not preoperative NLR, was an independent prognostic factor for both OS (P<0.001, HR = 2.39, 95%CI 1.53–3.72) and RFS (P = 0.003, HR = 1.69, 95%CI 1.87–8.24).ConclusionThe postoperative NLR change was an independent prognostic factor for small HCC patient undergoing RFA, and patients with decreased NLR indicated better survival than those with increased NLR.

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“…Other investigators have reported an association between high NLR and colorectal tumour size [41], poor differentiation [4] and mucinous type [42]. In contrast, only a couple of investigators failed to show any association between NLR and clinicopathological features or Dukes staging [43,44]. The pre-treatment value of NLR has also shown predictive value in guiding treatment regimens: for example, Kim et al [32] reported a poor rate of pathological complete response in patients with high pre-treatment NLR, undergoing preoperative chemoradiotherapy for locally advanced rectal cancers.…”

Section: Discussionmentioning

confidence: 99%

The Neutrophil-to-Lymphocyte Ratio as a Marker of Lymph Node Status in Patients with Rectal Cancer

Khan

Akritidis²,

Pring³

et al. 2016

Oncology

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Aim: The aim of the study was to investigate the role of the neutrophil-to-lymphocyte ratio (NLR) as a prognostic marker of rectal cancers. Methods: We undertook a retrospective review of patients with rectal cancer. Pre-treatment NLR was assessed for association and predictive values against clinicopathological staging and post-treatment outcomes. Results: A total of 140/180 cases were included in the final analysis [male:female 2:1; mean age 68 years (interquartile range 58-75)]. The pre-operative mean NLR was 5.4 ± 6.8. There was a strong positive correlation between NLR and C-reactive protein (Spearman's rho 64.3%, p < 0.001). A high NLR was associated with a positive nodal status on MRI (5.2 vs. 3.8, p = 0.03) and histopathological (4.8 vs. 3.8, p = 0.02) assessment. The NLR showed an average value for predicting MRI and pathological nodal status on receiver operating characteristic analysis [area under the curve = 0.72 (95% CI = 0.54-0.91), p = 0.031 and area under the curve = 0.64 (95% CI = 0.52-0.077), p = 0.021, respectively]. On multivariate analysis, the total lymph node retrieved at operation was the best predictor of pathological nodal involvement; NLR did not show any predictive value. Patients with an NLR >4 showed reduced recurrence-free (60 vs. 86 months, p = 0.52) and overall survival (57 vs. 84 months, p = 0.40) without statistical significance. Conclusion: Raised pre-treatment NLR may indicate nodal involvement in patients with rectal cancer.

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Elevated neutrophil to lymphocyte ratio might predict poor prognosis for colorectal liver metastasis after percutaneous radiofrequency ablation

Abstract: Elevated NLR (>5) might predict more extrahepatic metastasis and poorer survival for patients with CRLM after RFA.

Cited by 31 publications

References 33 publications

A Preoperative Neutrophil to Lymphocyte Ratio of 3 Predicts Disease-Free Survival After Curative Elective Colorectal Cancer Surgery

A Preoperative Neutrophil to Lymphocyte Ratio of 3 Predicts Disease-Free Survival After Curative Elective Colorectal Cancer Surgery

Postoperative Neutrophil-to-Lymphocyte Ratio Change Predicts Survival of Patients with Small Hepatocellular Carcinoma Undergoing Radiofrequency Ablation

The Neutrophil-to-Lymphocyte Ratio as a Marker of Lymph Node Status in Patients with Rectal Cancer

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