Elevated neutrophil to lymphocyte and platelet to lymphocyte ratios predict high grade and advanced stage renal cell carcinoma

Abstract

Introduction: Renal cell carcinoma is the most common malignancy of the kidney, which accounts 85% of all renal tumors. In recent years, the incidence of renal cell carcinoma was increased due to the widespread use of imaging techniques. The aim of this study is to investigate the clinical significance of pretreatment neutrophil to lymphocyte and platelet to lymphocyte ratios in patients with renal cell carcinomas. Methods: The patients who underwent nephrectomy for renal tumor between 2010 and 2018 in two centers were reviewed retrospectively. The age, sex, complete blood test, and pathological results were recorded. The patients who were diagnosed with other carcinomas, benign renal tumors, and missing data of age, complete blood test, and pathological results, were excluded. The patients were divided into two groups according to the T stage and Fuhrman grade, T1-2 and T3-4, G1-2 and G3-4. Results: There were 271 patients in the current study. The male to female ratio was 1.97 and the mean age of the patients was 59.37±11.62 years. Clear cell renal cell carcinoma was the most common subtype in 72.7% of the patients. Both the neutrophil to lymphocyte ratio and the platelet to lymphocyte ratio were significantly higher in patients with high-grade and advanced-stage disease than in the others. The receiver operating characteristic curve showed no significant difference between platelet to lymphocyte ratio and neutrophil to lymphocyte ratio to diagnose the high grade and stage of renal cell carcinoma. Conclusion: The neutrophil to lymphocyte and platelet to lymphocyte ratios are easily accessible biomarkers which are used for the prognosis of malignancy. The current study found that these biomarkers may predict the pathological results during the preoperative period. KeywordsNeutrophil to lymphocyte ratio, renal cell carcinoma, platelet to lymphocyte ratio Date

The Prognostic Value of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio for Small Renal Cell Carcinomas after Image-Guided Cryoablation or Radio-Frequency Ablation

“…We have found that, in general, increased post-operative or peri-operative change in NLR and PLR are significant negative predictors of overall survival, cancer-specific survival and metastasis-free survival, which is in agreement with previous studies [ 5 , 6 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 ] in this cohort of patients with localised small renal masses who have undergone image-guided ablation. Interestingly, we have also found PLR to be a significant predictor of a significant decline in renal function.…”

Prognostic Value of the Lymphocyte‐to‐Monocyte Ratio in Patients with Parotid Gland Carcinoma

“…These discrepancies may be attributable to the pathological variations in this study. It was previously reported that malignant bladder cancer, 32 renal cell carcinoma, 33 PGC, 34 and epithelial ovarian cancer 35 of high pathological grades exhibit higher NLR and GPS than do those with low pathological grades. Our study included PGCs of all pathological grades; as such, the ANC, ALC, CRP, and albumin might be more closely associated with the prognosis of patients with salivary duct carcinoma than are the ALC and AMC.…”

The role of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in determining the prognosis of patients with testicular cancer

“…IL-6 will promote thrombopoietin, leading to an increased platelet count in patients with malignancy. 6 Research investigating the prognostic value of PLR in 1528 patients with renal cancer carcinoma has shown that elevated PLR was an independent indicator of poor overall survival and progression-free survival. The results of the subgroup study concluded that PLR could serve as a reliable marker for cancer prognosis.…”

“…7 Calculation of NLR and PLR, which is known to have a role in determining the prognosis of cancer patients, has advantages in terms of cost-effectiveness compared to other markers such as examination of CRP levels. 6 Previous studies in patients undergoing transurethral resection-bladder due to bladder tumor surgery have identified that high NLR correlates with tumor grade and stage. In most studies examining the relationship between radical cystectomy outcomes and NLR, high NLR outcomes and worse ratios were found in diseasespecific and overall survival.…”