Elevated Monocyte Chemoattractant Protein-1 Serum Levels in Patients at Risk for Coronary Artery Disease

Abstract

Background Monocyte chemoattractant protein-1 (MCP-1) is involved in the recruitment of monocytes into the arterial vessel wall as one of the major events leading to atherosclerotic vascular diseases, such as coronary artery disease (CAD). Methods and ResultsThe study group comprised 263 volunteers aged between 18 and 85 years who were admitted to hospital or clinic for scheduled invasive and non-invasive diagnostic procedures. MCP-1 serum levels were determined using a sandwich-enzyme-linked immunosorbent assay. In each patient, the coronary risk factors (CRF), such as hypertension, high cholesterol, diabetes mellitus, obesity, positive family history, and smoking were evaluated. Low-density lipoprotein-cholesterol, lipoprotein(a), and hemoglobinA1C levels were determined. Patients with CAD proven by angiography had significantly increased MCP-1 levels. In patients without CAD, the increase in MCP-1 depended on the number of CRF. As a marker for endothelial activation the soluble adhesion molecules, soluble intercellular adhesion molecule and soluble E-selectin were measured and both markers were significantly elevated in patients with CAD or multiple CRF when compared with patients without CRF. Although this is not a direct proof, endothelial activation could contribute to elevated MCP-1 levels in atherosclerosis. Conclusion Elevated MCP-1 serum levels could serve as a direct marker of the inflammatory activity in patients at risk for coronary artery and other atherosclerotic vascular diseases. (Circ J 2005; 69: 1484 -1489

The +838 C/G MT2A Polymorphism, Metals, and the Inflammatory/Immune Response in Carotid Artery Stenosis in Elderly People

“…The higher CS incidence in the C-carriers is in line with the role of MCP-1 in atherogenesis, restenosis, and plaque destabilization (42)(43)(44) as well as with the fact that patients with stroke or cardiovascular diseases show elevated MCP-1 plasma levels (45,46). The increased platelet count and high fibrinogen concentrations that we found in C-subjects fit the known association of these factors with severe CS and risk of stroke (47,48).…”

Elevated Plasma Osteopontin Levels Were Associated With Osteopontin Expression of CD4+ T Cells in Patients With Unstable Angina

“…Monocyte chemoattractant protein-1 is a potent specific chemoattractant for monocytes and is reported to be elevated in patients with coronary artery disease and UA. 16,17 Recently, high levels of osteopontin mRNA and protein were reported in human atherosclerotic plaque from the aorta, carotid and coronary arteries. [18][19][20] Osteopontin facilitates the migration of endothelial cells, 22 and inhibits nitric oxide synthase expression in endothelial cells.…”

“…Some reports show an association between osteopontin and calcification, [16][17][18] so we excluded patients with coronary calcification detected by coronary arteriography. We studied 150 patients who underwent diagnostic catheterization (106 men, 44 women; mean age ± SD, 67±11 years) between October 2003 and February 2005.…”

Once fat was fat and that was that : our changing perspectives on adipose tissue

“…As this recruitment may lead to atherosclerosis, MCP-1 was measured in patients with or without CAD, and it was found to be elevated in the former group. 27 Adipocytes also secrete resistin, which stimulates inflammatory cytokine production, as well as decreasing endothelial cell adhesion molecule (iCAM-1, vCAM-1, Ccl-2) production, which may promote atherosclerosis. 28 The role of resistin in insulin resistance is still unclear.…”