Elevated maternal cortisol levels during pregnancy are associated with reduced childhood IQ

LeWinn, Kaja Z.; Stroud, Laura R.; Molnar, Beth E.; Ware, James H.; Buka, Stephen L.

doi:10.1093/ije/dyp200

Cited by 96 publications

(71 citation statements)

References 59 publications

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“…The selection process resulted in a total of 28 papers (Beijers et al, 2010;Bolten et al, 2011;Buitelaar et al, 2003;Buss et al, 2012;D'Anna-Hernandez et al, 2012;Davis et al, 2007Davis et al, , 2011Sandman, 2010, 2012;Diego et al, 2009;van Dijk et al, 2012;Ellman et al, 2008;Erickson et al, 2001;Goedhart et al, 2010;Gutteling et al, 2004Gutteling et al, , 2005aGutteling et al, ,b, 2006Gutteling et al, , 2007Huizink et al, 2003;Mercer et al, 2006;Rondó et al, 2010Rondó et al, , 2011Ruiz et al, 2001;LeWinn et al, 2009;de Weerth et al, 2003;Rothenberger et al, 2011;Tollenaar et al, 2011). The selected studies were published between 2001 and 2012.…”

Section: Identified Studiesmentioning

confidence: 99%

“…However, this association was not found for prenatal cortisol measured in week 31 of pregnancy. LeWinn et al (2009) examined the association between maternal serum cortisol (weeks 31-36; time of sampling not recorded) and IQ in 7 year olds and showed that higher maternal cortisol was related to a lower IQ. This association was most pronounced for verbal IQ, and not significant for performance IQ (LeWinn et al, 2009).…”

Section: Conclusion For Physical/health Outcome Studiesmentioning

confidence: 99%

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Associations between maternal prenatal cortisol concentrations and child outcomes: A systematic review

Zijlmans

Riksen‐Walraven

Weerth

2015

Neuroscience & Biobehavioral Reviews

181

138

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Section: Identified Studiesmentioning

confidence: 99%

Section: Conclusion For Physical/health Outcome Studiesmentioning

confidence: 99%

Associations between maternal prenatal cortisol concentrations and child outcomes: A systematic review

Zijlmans

Riksen‐Walraven

Weerth

2015

Neuroscience & Biobehavioral Reviews

181

138

View full text Add to dashboard Cite

“…Higher levels of cortisol during pregnancy have also been related to offspring IQ (LeWinn et al 2009), behavior and temperament (de Weerth et al 2013). …”

Section: Introductionmentioning

confidence: 99%

Determinants of cortisol during pregnancy – The ABCD cohort

Bleker

Roseboom

Vrijkotte

et al. 2017

Psychoneuroendocrinology

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Please cite this article as: Bleker, Laura S., Roseboom, Tessa J., Vrijkotte, Tanja G., Reynolds, Rebecca M., de Rooij, Susanne R., Determinants of Cortisol During Pregnancy − the ABCD Cohort.Psychoneuroendocrinology http://dx.doi.org/10. 1016/j.psyneuen.2017.05.026 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. later adverse health consequences. However, evidence linking maternal stress to maternal cortisol values during pregnancy is inconclusive. A possible explanation for this is that other maternal factors overshadow any potential effects of stress on cortisol levels. We studied a large cohort of pregnant women with extensive data on pregnancy characteristics to determine the respective contributions of biological, environmental and psychosocial stress factors to cortisol levels in pregnancy. Methods:We used data from 3039 women from the Amsterdam Born Children and their Development-study cohort. Serum cortisol was measured in blood, collected at the first prenatal visit, at different gestational ages (median=91 days, range=40-256 days), and at various time points during the day (median=11:45h, range=08:00 -18:30h). We assessed associations between maternal serum cortisol in pregnancy and biological factors, lifestyle factors and stress factors, including depression, anxiety, pregnancy-related anxiety, work stress, parenting stress and fatigue. Results:In multivariable analysis, variables that were associated with higher cortisol levels in pregnancy were lower maternal age [1.5 nmol/l, 95%CI (0.6 to 2. Conclusions: Our data suggest that maternal cortisol during pregnancy is mainly affected by biological and lifestyle factors, but not by psychosocial factors. We suggest that psychosocial stress in Laura S. Bleker 3 pregnancy might program the fetus through other mechanisms than through altering maternal cortisol levels.

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“…Recurrent ocular toxoplasmosis has also been reported in patients receiving systemic corticosteroid therapy (dose range, 0.27-1.23 mg/kg/day) [756] . The study of Ahlbom et al [757] suggested that prenatal exposure to excess of GCs increased the susceptibility of cerebellar granule cells to oxidative stress-induced cell death, and elevated maternal cortisol levels during pregnancy have been associated with reduced childhood IQ [758] . It must be emphasized that in mice brains infected with T. gondii electron microscopy revealed that cortisone increased the amount of tachyzoites, cysts and cystozoites, as the rupture of cysts released a highly resistant antigen of cystozoite type [759] .…”

Section: Atherosclerosismentioning

confidence: 99%

Possible Pivotal Role of Latent Chronic T. gondii Infection in the Pathogenesis of Atherosclerosis

Prandota

2017

Journal of Cardiology and Therapy

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Elevated maternal cortisol levels during pregnancy are associated with reduced childhood IQ

Abstract: These findings are consistent with prior human and animal studies, and suggest that exposure to high levels of maternal cortisol during pregnancy may be negatively related to offspring cognitive skills independently of family attributes that characterize the postnatal environment.

Cited by 96 publications

References 59 publications

Associations between maternal prenatal cortisol concentrations and child outcomes: A systematic review

Associations between maternal prenatal cortisol concentrations and child outcomes: A systematic review

Determinants of cortisol during pregnancy – The ABCD cohort

Possible Pivotal Role of Latent Chronic T. gondii Infection in the Pathogenesis of Atherosclerosis

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