Elevated Manganese Concentrations in Drinking Water May Be Beneficial for Fetal Survival

Rahman, Syed Moshfiqur; Åkesson, Agneta; Kippler, Maria; Grandér, Margaretha; Hamadani, Jena Derakhshani; Streatfield, Peter Kim; Persson, Lars‐Åke; Arifeen, Shams El; Vahter, Marie

doi:10.1371/journal.pone.0074119

Cited by 21 publications

(12 citation statements)

References 32 publications

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“…An additional concern pertains to the participation rates, which were not reported and so factors that might distinguish participants from non-participants are not clear. Similar to the aforementioned studies in India, concurrent contamination of wells by other potentially important trace elements, such as manganese, might have confounded results reported from Bangladesh (Rahman et al, 2013). …”

Section: Resultsmentioning

confidence: 74%

Maternal arsenic exposure and birth outcomes: A comprehensive review of the epidemiologic literature focused on drinking water

Bloom

Surdu

Neamtiu³

et al. 2014

International Journal of Hygiene and Environmental Health

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Inorganic arsenic (iAs) is a human toxicant to which populations may be exposed through consumption of geogenically contaminated groundwater. A growing body of experimental literature corroborates the reproductive toxicity of iAs; however, the results of human studies are inconsistent. Therefore, we conducted a comprehensive review of epidemiologic studies focused on drinking water iAs exposure and birth outcomes to assess the evidence for causality and to make recommendations for future study. We reviewed 18 English language papers assessing birth weight, gestational age, and birth size. Thirteen of the studies were conducted among populations with frequent exposure to high-level groundwater iAs contamination (>10 μg/L) and five studies were conducted in areas without recognized contamination. Most studies comprised small samples and used cross-sectional designs, often with ecologic exposure assessment strategies, although several large prospective investigations and studies with individual-level measurements were also reported. We conclude that: 1) the epidemiologic evidence for an increased risk of low birth weight (<2,500 grams) is insufficient, although there exists limited evidence for birth weight decreases; 2) the evidence for increased preterm delivery is insufficient; and, 3) there exists minimal evidence for decreased birth size. In further investigation of birth weight and size, we recommend incorporation of individual susceptibility measures using appropriate biomarkers, with collection timed to windows of vulnerability and speciated arsenic analysis, as well as consideration of populations exposed primarily to drinking water iAs contamination <10 μg/L. Given the large potential public health impact, additional, high quality epidemiologic studies are necessary to more definitively assess the risk.

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Section: Resultsmentioning

confidence: 74%

Maternal arsenic exposure and birth outcomes: A comprehensive review of the epidemiologic literature focused on drinking water

Bloom

Surdu

Neamtiu³

et al. 2014

International Journal of Hygiene and Environmental Health

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“…When present in drinking water in concentrations up to several mg/L, manganese may impair the intellectual development in children (Wasserman et al ). The substitution of As‐polluted groundwaters in PC aquifers by Mn‐rich groundwaters from PI aquifers of brown sand therefore carries with it an element of risk substitution, although we note that such concentrations may also be beneficial during pregnancy (Rahman et al ). Excepting for school wells, exploitation of brown PI aquifers may offer an acceptable risk substitution of Mn for As, given the evidence that As is such a hazard to health in the Bengal Basin.…”

Section: Discussionmentioning

confidence: 89%

Palaeosol Control of Arsenic Pollution: The Bengal Basin in West Bengal, India

Ghosal

Sikdar

McArthur³

2014

Groundwater

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Groundwater in the Bengal Basin is badly polluted by arsenic (As) which adversely affects human health. To provide low-As groundwater for As mitigation, it was sought across 235 km 2 of central West Bengal, in the western part of the basin. By drilling 76 boreholes and chemical analysis of 535 water wells, groundwater with <10 μg/L As in shallow aquifers was found under one-third of a study area. The groundwater is in late Pleistocene palaeo-interfluvial aquifers of weathered brown sand that are capped by a palaeosol of red clay. The aquifers form two N-S trending lineaments that are bounded on the east by an As-polluted deep palaeo-channel aquifer and separated by a shallower palaeo-channel aquifer. The depth to the top of the palaeo-interfluvial aquifers is mostly between 35 and 38 m below ground level (mbgl). The palaeo-interfluvial aquifers are overlain by shallow palaeo-channel aquifers of gray sand in which groundwater is usually As-polluted. The palaeosol now protects the palaeo-interfluvial aquifers from downward migration of As-polluted groundwater in overlying shallow palaeo-channel aquifers.The depth to the palaeo-interfluvial aquifers of 35 to 38 mbgl makes the cost of their exploitation affordable to most of the rural poor of West Bengal, who can install a well cheaply to depths up to 60 mbgl. The protection against pollution afforded by the palaeosol means that the palaeo-interfluvial aquifers will provide a long-term source of low-As groundwater to mitigate As pollution of groundwater in the shallower, heavily used, palaeo-channel aquifers. This option for mitigation is cheap to employ and instantly available.

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“…By contrast, Rahman et al. (2013) observed a reduced odds ratio for spontaneous abortions in a cohort with the highest drinking water tertile (667–3338 µg L −1 ) compared to a cohort with the lowest tertile (17–97 µg L −1 ) …”

Section: Possible Health Effectsmentioning

confidence: 93%

Dietary Manganese Exposure in the Adult Population in Germany—What Does it Mean in Relation to Health Risks?

Sachse

Kolbaum

Ziegenhagen

et al. 2019

Molecular Nutrition Food Res

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Manganese is both an essential nutrient and a potential neurotoxicant. Therefore, the question arises whether the dietary manganese intake in the German population is on the low or high side. Results from a pilot total diet study in Germany presented here reveal that the average dietary manganese intake in the general population in Germany aged 14–80 years is about 2.8 mg day−1 for a person of 70 kg body weight. This exposure level is within the intake range of 2–5 mg per person and day as recommended by the societies for nutrition in Germany, Austria, and Switzerland. No information on the dietary exposure of children in Germany can be provided so far. Although reliable information on health effects related to oral manganese exposure is limited, there is no indication from the literature that these dietary intake levels are associated with adverse health effects either by manganese deficiency or excess. However, there is limited evidence that manganese taken up as a highly bioavailable bolus, for example, uptake via drinking water or food supplements, could pose a potential risk to human health—particularly in certain subpopulations—when certain intake amounts, which are currently not well defined, are exceeded.

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Elevated Manganese Concentrations in Drinking Water May Be Beneficial for Fetal Survival

Cited by 21 publications

References 32 publications

Maternal arsenic exposure and birth outcomes: A comprehensive review of the epidemiologic literature focused on drinking water

Maternal arsenic exposure and birth outcomes: A comprehensive review of the epidemiologic literature focused on drinking water

Palaeosol Control of Arsenic Pollution: The Bengal Basin in West Bengal, India

Dietary Manganese Exposure in the Adult Population in Germany—What Does it Mean in Relation to Health Risks?

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