Elevated MACC1 Expression in Colorectal Cancer Is Driven by Chromosomal Instability and Is Associated with Molecular Subtype and Worse Patient Survival

Vuaroqueaux, Vincent; Musch, Alexandra; Kobelt, Dennis; Risch, Thomas S.; Herrmann, Pia; Burock, Susen; Peille, Anne-Lise; Yaspo, Marie–Laure; Fiebig, Heinz‐Herbert; Stein, Ulrike

doi:10.3390/cancers14071749

Cited by 4 publications

(2 citation statements)

References 55 publications

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“…To further understand the CIN‐associated feature of the cells between epithelial cells with higher‐ and lower‐CNV, we analysed the differential expressed genes and found a total of 60 downregulated genes and 118 upregulated genes were identified in the epithelial cells with higher CNV higher (Figure S7C). The results showed that higher‐CNV cells expressed genes correlated with higher CIN such as TMEM173, 67 TP53/MDM2, 68 EGFR, 69 MACC1, 70 FOS, 70 UBAC2 71 (Figure 7H). These results indicated that epithelial cells with higher‐ and lower‐CNV exhibited higher and lower CIN.…”

Section: Resultsmentioning

confidence: 96%

Single‐cell RNA sequencing reveals cellular and molecular reprograming landscape of gliomas and lung cancer brain metastases

Sun

Lao

et al. 2022

Clinical & Translational Med

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Background Brain malignancies encompass gliomas and brain metastases originating from extracranial tumours including lung cancer. Approximately 50% of patients with lung adenocarcinoma (LUAD) will eventually develop brain metastases. However, the specific characteristics of gliomas and lung‐to‐brain metastases (LC) are largely unknown. Methods We applied single‐cell RNA sequencing to profile immune and nonimmune cells in 4 glioma and 10 LC samples. Results Our analysis revealed that tumour microenvironment (TME) cells are present in heterogeneous subpopulations. LC reprogramed cells into immune suppressed state, including microglia, macrophages, endothelial cells, and CD8+ T cells, with unique cell proportions and gene signatures. Particularly, we identified that a subset of macrophages was associated with poor prognosis. ROS (reactive oxygen species)‐producing neutrophils was found to participant in angiogenesis. Furthermore, endothelial cells participated in active communication with fibroblasts. Metastatic epithelial cells exhibited high heterogeneity in chromosomal instability (CIN) and cell population. Conclusions Our findings provide a comprehensive understanding of the heterogenicity of the tumor microenvironment and tumour cells and it will be crucial for successful immunotherapy development for brain metastasis of lung cancer.

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Section: Resultsmentioning

confidence: 96%

Single‐cell RNA sequencing reveals cellular and molecular reprograming landscape of gliomas and lung cancer brain metastases

Sun

Lao

et al. 2022

Clinical & Translational Med

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“…Identification of molecular subtypes in cancers contributes to more accurate prognostic assessment due to substantial phenotypic and molecular heterogeneity among patients, and simultaneously is an important basis for individualized therapy and precision medicine. Studies about molecular subtypes have been widely concerned with diverse cancer types, such as breast cancer [ 31 , 32 ], colon cancer [ 33 , 34 ] and gastric cancer [ 35 ], which provide potentially crucial data for diagnosis and treatment. In prostate cancer, via a comprehensive molecular analysis, seven major molecular subtypes are characterized by the Cancer Genome Atlas Research Network, TCGA-PRAD project [ 36 ], and relevant studies are also carried out to provide more data in cancer treatment [ 37 , 38 , 39 ].…”

Section: Discussionmentioning

confidence: 99%

Characterization of Immune-Based Molecular Subtypes and Prognostic Model in Prostate Adenocarcinoma

Guo

Kang

Xia

et al. 2022

Genes

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Prostate adenocarcinoma (PRAD), also named prostate cancer, the most common visceral malignancy, is diagnosed in male individuals. Herein, in order to obtain immune-based subtypes, we performed an integrative analysis to characterize molecular subtypes based on immune-related genes, and further discuss the potential features and differences between identified subtypes. Simultaneously, we also construct an immune-based risk model to assess cancer prognosis. Our findings showed that the two subtypes, C1 and C2, could be characterized, and the two subtypes showed different characteristics that could clearly describe the heterogeneity of immune microenvironments. The C2 subtype presented a better survival rate than that in the C1 subtype. Further, we constructed an immune-based prognostic model based on four screened abnormally expressed genes, and they were selected as predictors of the robust prognostic model (AUC = 0.968). Our studies provide reference for characterization of molecular subtypes and immunotherapeutic agents against prostate cancer, and the developed robust and useful immune-based prognostic model can contribute to cancer prognosis and provide reference for the individualized treatment plan and health resource utilization. These findings further promote the development and application of precision medicine in prostate cancer.

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Novel insights on the positive correlation between sense and antisense pairs on gene expression

Das,

Zea Rojas,

Tran

2024

WIREs RNA

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A considerable proportion of the eukaryotic genome undergoes transcription, leading to the generation of noncoding RNA molecules that lack protein‐coding information and are not subjected to translation. These noncoding RNAs (ncRNAs) are well recognized to have essential roles in several biological processes. Long noncoding RNAs (lncRNAs) represent the most extensive category of ncRNAs found in the human genome. Much research has focused on investigating the roles of cis‐acting lncRNAs in the regulation of specific target gene expression. In the majority of instances, the regulation of sense gene expression by its corresponding antisense pair occurs in a negative (discordant) manner, resulting in the suppression of the target genes. The notion that a negative correlation exists between sense and antisense pairings is, however, not universally valid. In fact, several recent studies have reported a positive relationship between corresponding cis antisense pairs within plants, budding yeast, and mammalian cancer cells. The positive (concordant) correlation between anti‐sense and sense transcripts leads to an increase in the level of the sense transcript within the same genomic loci. In addition, mechanisms such as altering chromatin structure, the formation of R loops, and the recruitment of transcription factors can either enhance transcription or stabilize sense transcripts through their antisense pairs. The primary objective of this work is to provide a comprehensive understanding of both aspects of antisense regulation, specifically focusing on the positive correlation between sense and antisense transcripts in the context of eukaryotic gene expression, including its implications towards cancer progression.This article is categorized under: RNA Processing > 3′ End Processing Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs

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Elevated MACC1 Expression in Colorectal Cancer Is Driven by Chromosomal Instability and Is Associated with Molecular Subtype and Worse Patient Survival

Cited by 4 publications

References 55 publications

Single‐cell RNA sequencing reveals cellular and molecular reprograming landscape of gliomas and lung cancer brain metastases

Single‐cell RNA sequencing reveals cellular and molecular reprograming landscape of gliomas and lung cancer brain metastases

Characterization of Immune-Based Molecular Subtypes and Prognostic Model in Prostate Adenocarcinoma

Novel insights on the positive correlation between sense and antisense pairs on gene expression

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