Elevated M2-muscarinic and β1-adrenergic receptor autoantibody levels are associated with paroxysmal atrial fibrillation

Yalçın, Muhammed Ulvi; Gürses, Kadri Murat; Koçyiğit, Duygu; Kesikli, S. Altug; Ateş, Ahmet Hakan; Evranos, Banu; Yorgun, Hikmet; Şahiner, Mehmet Levent; Kaya, Ergün Barış; Oto, Mehmet Ali; Güç, Dicle; Özer, Necla; Aytemir, Kudret

doi:10.1007/s00392-014-0776-1

Cited by 30 publications

(27 citation statements)

References 19 publications

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“…Similar results were also found by Yalcin et al [9] in patients with lone paroxysmal AF in a recent study in which lone paroxysmal AF patients had significantly higher serum anti-M2-R level than healthy controls and the anti-M2-R level was an independent predictor for the presence of lone paroxysmal AF. In addition, pre-procedural anti-M2-R level was found to predict the recurrence of AF after catheter ablation.…”

supporting

confidence: 88%

“…c o m / l o c a t e / i j c a r d AF than those with sinus rhythm [14]. In patients with lone paroxysmal AF, serum anti-β1-R level was significantly higher than healthy controls and the anti-β1-R level was an independent predictor for the presence of lone paroxysmal AF [9]. Just as serum anti-M2-R level plays a predictive role in AF recurrence after catheter ablation, pre-procedural serum anti-β1-R level was also an independent predictor of late AF recurrence following cryoablation in paroxysmal AF patients [11].…”

Section: Contents Lists Available At Sciencedirectmentioning

confidence: 91%

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Autoantibodies against M2-muscarinic and β adrenergic receptors: New mediators in atrial fibrillation?

He¹,

Lu²,

He³

et al. 2015

International Journal of Cardiology

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supporting

confidence: 88%

Section: Contents Lists Available At Sciencedirectmentioning

confidence: 91%

Autoantibodies against M2-muscarinic and β adrenergic receptors: New mediators in atrial fibrillation?

He¹,

Lu²,

He³

et al. 2015

International Journal of Cardiology

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“…Recent findings from our group suggest that β1AR and M2 muscarinic receptor autoantibodies are also related to a propensity for atrial fibrillation (AF) in Graves’ hyperthyroidism [12]. A similar observation has been reported for lone paroxysmal AF [13]. …”

Section: Introductionmentioning

confidence: 56%

A peptidomimetic inhibitor suppresses the inducibility of β1-adrenergic autoantibody-mediated cardiac arrhythmias in the rabbit

Zhang

Huang

et al. 2015

J Interv Card Electrophysiol

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Purpose Previous studies demonstrated that burst pacing and subthreshold infusion of acetylcholine in β1-adrenergic receptor (β1AR)-immunized rabbits induced sustained sinus tachycardia. The aim of this study was to examine the anti-arrhythmogenic effect of a newly designed retro-inverso (RI) peptidomimetic inhibitor that specifically targets the β1AR antibodies in the rabbit. Methods Six New Zealand white rabbits were immunized with a β1AR second extracellular loop peptide to produce sympathomimetic β1AR antibodies. A catheter-based electrophysiological study was performed on anesthetized rabbits before and after immunization and subsequent treatment with the RI peptide inhibitor. Each rabbit served as its own control. Results No sustained arrhythmias were induced at preimmune baseline. At 6 weeks after immunization, there was a marked increase in induced sustained tachyarrhythmias, predominantly sinus tachycardia, which was largely suppressed by the RI peptide. The atrial effective refractory period was shortened significantly in immunized rabbits compared to their preimmune state. The RI peptide reversed and prolonged this shortening. β1AR antibody levels were negatively correlated with the atrial effective refractory period. Postimmune sera-induced β1AR activation in transfected cells in vitro was also blocked by the RI peptide. Conclusions β1AR-activating autoantibodies are associated with reduction of the atrial effective refractory period and facilitate arrhythmia induction in this model. The RI peptide reversal may have important therapeutic implications in subjects who harbor these autoantibodies.

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“…Autoimmunity has been observed in several cardiovascular diseases, such as DCM, rheumatic fever, myocarditis, hypertension and arrhythmia [11, 12]. β 1 R, β 2 R, α 1 R, M 2 R and AT 1 R were the major adrenergic, muscarinic and angiotensin receptors presented in myocardial tissue respectively.…”

Section: Discussionmentioning

confidence: 99%

Multiple Autoantibodies against Cardiovascular Receptors as Biomarkers in Hypertensive Heart Disease

et al. 2019

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Objectives: The pathogenesis of hypertensive heart disease (HHD) remains unclear, which might include autoimmunity. The aim of the present study was to determine whether a relationship exists between the presence of autoantibodies against β₁, β₂, α₁ adrenoreceptors, M₂-muscarinic receptors, angiotensin II type₁ receptors and HHD. Methods: In the present study, 44 patients diagnosed with HHD, 36 patients with hypertension, and 40 controls were also enrolled. The measurement of these 5 autoantibodies was performed by enzyme-linked immunosorbent assay. Results: The frequencies of autoantibodies against β₁, β₂, α₁ adrenoreceptors, autoantibodies against M₂-muscarinic receptors and autoantibodies against angiotensin II type₁ receptors were significantly higher in patients with HHD, when compared to patients with hypertension and normal controls (all p < 0.001). In addition, the titers of these 5 autoantibodies significantly increased in patients with HHD. Patients who were positive for all 5 autoantibodies had larger left ventricular end-diastolic diameter (60.5 ± 4.9 vs. 57.8 ± 5.0 vs. 52.5 ± 5.3 mm) and worse left ventricular ejection fraction (45.0 ± 11.0 vs. 56.6 ± 10.4 vs. 57.8 ± 5.3%), when compared to patients not positive for all the 5 autoantibodies and patients negative for all the 5 autoantibodies (χ² = 9.524, p = 0.009 and χ² = 7.689, p = 0.021). Furthermore, a significant positive correlation was observed between each 2 autoantibodies of these 5 autoantibodies (all p < 0.001). Conclusion: Multiple autoantibodies of cardiovascular receptors may be involved in the pathogenesis and may be predictive factors of HHD.

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Elevated M2-muscarinic and β1-adrenergic receptor autoantibody levels are associated with paroxysmal atrial fibrillation

Abstract: Our results demonstrated that higher serum anti-M2-R and anti-β1-R levels are associated with lone PAF. Autoantibodies related to autonomic system may play an important role in the development of lone AF.

Cited by 30 publications

References 19 publications

Autoantibodies against M2-muscarinic and β adrenergic receptors: New mediators in atrial fibrillation?

Autoantibodies against M2-muscarinic and β adrenergic receptors: New mediators in atrial fibrillation?

A peptidomimetic inhibitor suppresses the inducibility of β1-adrenergic autoantibody-mediated cardiac arrhythmias in the rabbit

Multiple Autoantibodies against Cardiovascular Receptors as Biomarkers in Hypertensive Heart Disease

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