Elevated lipoprotein(a) and hs-CRP as a poor prognostic marker in patients with coronary artery disease

Kwon, Seong Ryul; Yoon, Young Won; Lee, B.; Hong, Bum–Kee; Kwon, Hyuck Moon

doi:10.1016/j.atherosclerosis.2015.04.084

Cited by 2 publications

(2 citation statements)

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“…Lipid abnormalities and inflammation are the main pathological changes of atherosclerosis, and their simultaneous detection can more accurately predict the progression of atherosclerosis 15–17 . In primary and secondary prevention of CVD, according to Mangalmurti and Davidson, lipid biomarkers, such as Apo B, LDL‐P, and Lp(a), may have clinical utility, and inflammatory markers, such as hs‐CRP, may be useful for evaluating residual risk 18 .…”

Section: Discussionmentioning

confidence: 99%

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Time‐resolved fluorescence immunoassay (TRFIA) for the simultaneous detection of hs‐CRP and lipoprotein(a) in serum

Mao

Zhu

et al. 2022

Biotech and App Biochem

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Elevated serum high-sensitivity C-reactive protein (hs-CRP) and lipoprotein(a) (Lp(a)) levels are associated with the development of native coronary atherosclerosis. We aimed to establish a new method for the simultaneous detection of hs-CRP and Lp(a) to predict the development of atherosclerosis. A one-step time-resolved fluorescence immunoassay (TRFIA) with europium(III) (Eu 3+ ) or samarium(III) (Sm 3+ ) labels was established, and the performance of this TRFIA (in terms of sensitivity, specificity, accuracy, and cutoff values) was evaluated using clinical serum samples and compared with those of registered kits. The sensitivity was 0.052 μg/ml for hs-CRP and 0.64 μg/ml for Lp(a). The intra-assay and inter-assay cross-reactivities (CVs) were very low, ranging from 2.05% to 4.67% for hs-CRP and from 2.42% to 6.43% for Lp(a). The CVs were very low (<0.34% and <2.65%, respectively) with five interferents. Additionally, there was a high Pearson coefficient between the present TRFIA method and the registered kits (R 2 = 0.9967 and 0.9906, respectively). These data indicate that this study developed a TRFIA method that can be used for the quantitative detection of hs-CRP and Lp(a) in serum with high sensitivity, specificity, and accuracy. This TRFIA provides a new method for predicting the development of atherosclerosis.

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Section: Discussionmentioning

confidence: 99%

“…Numerous clinical studies have confirmed that hs‐CRP and Lp(a) are poor prognostic markers in patients with coronary artery disease and are independent risk factors for CHD events 3–7,15 . Clinically, many commercialized kits are available for detecting serum levels of hs‐CRP and Lp(a) to assess the risk of CHD events.…”

Section: Discussionmentioning

confidence: 99%

Time‐resolved fluorescence immunoassay (TRFIA) for the simultaneous detection of hs‐CRP and lipoprotein(a) in serum

Mao

Zhu

et al. 2022

Biotech and App Biochem

View full text Add to dashboard Cite

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Metalloporphyrin-based porous polymers prepared via click chemistry for size-selective adsorption of protein

Zhu

Qin

et al. 2018

Journal of Biomaterials Science, Polymer Edition

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Zinc porphyrin-based porous polymers (PPs-Zn) with different pore sizes were prepared by controlling the reaction condition of click chemistry, and the protein adsorption in PPs-Zn and the catalytic activity of immobilized enzyme were investigated. PPs-Zn-1 with 18 nm and PPS-Zn-2 with 90 nm of pore size were characterized by FTIR, NMR and nitrogen absorption experiments. The amount of adsorbed protein in PPs-Zn-1 was more than that in PPs-Zn-2 for small size proteins, such as lysozyme, lipase and bovine serum albumin (BSA). And for large size proteins including myosin and human fibrinogen (HFg), the amount of adsorbed protein in PPs-Zn-1 was less than that in PPs-Zn-2. The result indicates that the protein adsorption is size-selective in PPs-Zn. Both the protein size and the pore size have a significant effect on the amount of adsorbed protein in the PPs-Zn. Lipase and lysozyme immobilized in PPs-Zn exhibited excellent reuse stability.

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Elevated lipoprotein(a) and hs-CRP as a poor prognostic marker in patients with coronary artery disease

Cited by 2 publications

References 0 publications

Time‐resolved fluorescence immunoassay (TRFIA) for the simultaneous detection of hs‐CRP and lipoprotein(a) in serum

Time‐resolved fluorescence immunoassay (TRFIA) for the simultaneous detection of hs‐CRP and lipoprotein(a) in serum

Metalloporphyrin-based porous polymers prepared via click chemistry for size-selective adsorption of protein

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