2016
DOI: 10.1016/j.spinee.2015.10.038
|View full text |Cite
|
Sign up to set email alerts
|

Elevated levels of tumor necrosis factor-α and TNFR1 in recurrent herniated lumbar discs correlate with chronicity of postoperative sciatic pain

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

1
25
0

Year Published

2016
2016
2024
2024

Publication Types

Select...
6
1

Relationship

0
7

Authors

Journals

citations
Cited by 29 publications
(26 citation statements)
references
References 33 publications
1
25
0
Order By: Relevance
“…Recent research shows that the expression of proinflammatory cytokines, such as TNF‐α, IL‐1β, IL‐6, and IL8, is associated with the severity of DDD in both human and animal models (Andrade et al, ; Bachmeier et al, ; Le Maitre, Freemont, & Hoyland, ; Le Maitre, Hoyland, & Freemont, ; Sutovsky et al, ). In the current study, intradiscal injection of TNF‐α combined with degenerative culture conditions caused a marked up‐regulation of proinflammatory cytokine expression equivalent to the above‐mentioned findings in degenerated IVD.…”
Section: Discussionmentioning
confidence: 99%
“…Recent research shows that the expression of proinflammatory cytokines, such as TNF‐α, IL‐1β, IL‐6, and IL8, is associated with the severity of DDD in both human and animal models (Andrade et al, ; Bachmeier et al, ; Le Maitre, Freemont, & Hoyland, ; Le Maitre, Hoyland, & Freemont, ; Sutovsky et al, ). In the current study, intradiscal injection of TNF‐α combined with degenerative culture conditions caused a marked up‐regulation of proinflammatory cytokine expression equivalent to the above‐mentioned findings in degenerated IVD.…”
Section: Discussionmentioning
confidence: 99%
“…TNF-α levels are significantly increased in IVD samples derived from recurrent lumbar disc herniation patients and positively correlate with postoperative sciatic pain severity [135]. Moreover, there is accumulating evidence which indicates that TNF-α aggravates disc herniation by amplifying inflammatory responses and decreasing IVD cell viability [136,137].…”
Section: Tnf-α and Disc Herniationmentioning
confidence: 99%
“…TNF-α is one type of inflammatory cytokines which is secreted by monocytes and macrophages, and plays an important role in inflammatory response, cells proliferation, and apoptosis [36,37]. TNF-α is also a critical inflammatory cytokines causing IVDD [38,39]. Andrade et al [38] found that when compared with first time lumbar disc herniation (LDH) patients, recurrent LDH patients had higher levels of TNF-α, and they discovered that TNF-α and its receptors (TNFR) were correlated with the severity of pre- and post-operative leg pain in LDH patients; conclusions which our study supports.…”
Section: Discussionmentioning
confidence: 99%