Elevated levels of soluble glycoprotein V - The plasma marker of platelet activation by thrombin in patients with early stage primary biliary cholangitis (PBC)

Rogalski, Paweł; Bogdanowska-Charkiewicz, Dagmara; Plonska, Magdalena Rogalska –; Łukaszewicz-Zając, Marta; Roslen, Ines Kostecka –; Mroczko, Barbara; Dąbrowska, Milena; Berger, Justyna Wasielica –; Aleksiejuk, Elzbieta; Antonowicz, Stefania; Dâbrowski, A; Daniluk, Jarosław; Janica, Jerzy

doi:10.1016/j.advms.2023.01.002

Cited by 1 publication

(1 citation statement)

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“…It is known that Epstein-Barr virus infection induces autoimmune liver diseases including PBC [ 31 , 32 ]. Recent studies have identified elevated platelet activation in early-stage PBC patients [ 33 , 34 ]. Patients with PBC have increased risks of osteoporosis, which is a common complication in PBC [ 35 , 36 ], and pathways in osteoclast differentiation are associated with autoimmune diseases and PBC [ 37 , 38 ].…”

Section: Resultsmentioning

confidence: 99%

Bioinformatic analysis identified novel candidate genes with the potentials for diagnostic blood testing of primary biliary cholangitis

Pham,

Sato

2023

PLoS ONE

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Primary biliary cholangitis (PBC) is an autoimmune disorder characterized by intrahepatic bile duct destruction and cholestatic liver injury. Diagnosis of PBC is generally based on the existence of anti-mitochondrial antibody (AMA) in blood samples; however, some PBC patients are negative for serum AMA tests, and invasive liver histological testing is required in rare PBC cases. The current study seeks novel candidate genes that are associated with PBC status and have potentials for blood diagnostic testing. Human transcriptomic profiling data of liver and blood samples were obtained from Gene Expression Omnibus (GEO). Three GEO data series (GSE79850, GSE159676, and GSE119600) were downloaded, and bioinformatic analyses were performed. Various differentially expressed genes were identified in three data series by comparing PBC patients and control individuals. Twelve candidate genes were identified, which were upregulated in both liver tissues and blood samples of PBC patients in all three data series. The enrichment analysis demonstrated that 8 out of 12 candidate genes were associated with biological functions, which were closely related to autoimmune diseases including PBC. Candidate genes, especially ITGAL showed good potentials to distinguish PBC with other diseases. These candidate genes could be useful for diagnostic blood testing of PBC, although further clinical studies are required to evaluate their potentials as diagnostic biomarkers.

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