Elevated levels of plasma triglycerides are associated with histologically defined piemenopausal breast cancer risk

Goodwin, Pamela J.; Boyd, N F; Hanna, Wedad; Hartwick, Warren; Murray, David M.; Qizilbash, Ali H.; Redwood, Sheila; Hood, Nicky; DelGiudice, M E; Sidlofsky, Saul; McCready, David R.; Wilkinson, Rosemary; Mahoney, Leo J.; Connelly, Philip W.; Page, David L.

doi:10.1080/01635589709514539

Cited by 46 publications

(26 citation statements)

References 45 publications

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“…However, no signi®cant dierences were observed for total cholesterol, HDL cholesterol, and LDL cholesterol between cases and controls. In support of our ®nding, a few studies have found higher total cholesterol, LDL cholesterol, and triglyceride levels in breast cancer patients than in controls (Kumar et al 1991;Zielinski et al 1988) or no consistent patterns of alterations in total cholesterol and LDL cholesterol (KoÈ kogAE lu et al 1994; Goodwin et al 1997).…”

Section: Discussionsupporting

confidence: 51%

Plasma lipid alterations in African-American women with breast cancer

Agurs‐Collins

Kim

Dunston

et al. 1998

Journal of Cancer Research and Clinical Oncology

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The purpose of this study was to examine the relationship between plasma lipid and lipoprotein levels, stage of disease and breast cancer risk in African-American women. The study population comprised 163 African-American women: patients (n = 58) and controls (n = 105), with mean ages of 57.2 years and 47.7 years respectively. Approximately 71% and 56% of the women with breast cancer and the control population, respectively, were postmenopausal. Those with cancer had significantly higher education levels, P < or = 0.01, and higher triglyceride levels compared to the controls, P < or = 0.001, but lower body mass index (BMI) levels, P < or = 0.01. There were no statistically significant differences observed in total cholesterol, high-density-lipoprotein-containing cholesterol and low-density-lipoprotein-containing cholesterol between the patients and controls. After adjustments for age, education, BMI, and menopausal status, triglycerides remained significantly and positively associated with breast cancer risk. The significant correlation between the high levels of triglycerides and breast cancer risk (odds ratio = 5.12) may be attributed to differences in lipid metabolism between the women with breast cancer and controls, or to the consequences of breast cancer.

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Section: Discussionsupporting

confidence: 51%

Plasma lipid alterations in African-American women with breast cancer

Agurs‐Collins

Kim

Dunston

et al. 1998

Journal of Cancer Research and Clinical Oncology

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“…TG levels were significantly higher in women with node-negative invasive cancer (0.94 +/-1.04 mg/ml) than in those with no epithelial proliferation (0.83 +/-1.04 mg/ml, p=0.03). This association persisted after adjustment for age, body size, lipids, reproductive and familial risk factors, and previous benign breast problems (p<0.01), in keeping with an independent association of elevated TG with breast cancer risk [28]. Several studies have also shown significant increase in TG levels of breast cancer patients [21][22][23][24]27].…”

Section: Discussionmentioning

confidence: 53%

The Relationship between Serum Lipids and Breast Cancer in Libya

Jarari¹

2012

Biochem Anal Biochem

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“…There was some speculation that blood lipid levels could be affected by surgery as part of the metabolic and neuroendocrine response to the procedure [52], but a recent study demonstrated that triglyceride levels were almost identical in blood samples obtained before and after breast cancer surgery [32]. There is evidence that blood lipid levels can be affected by chemotherapy and tamoxifen treatment [53±55].…”

Section: Discussionmentioning

confidence: 99%

Apolipoprotein E genetic polymorphism, serum lipoproteins, and breast cancer risk

et al. 2000

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Apolipoprotein E (apoE) is a polymorphic gene involved in lipid metabolism with three common variant alleles (epsilon2, epsilon3, and epsilon4). The epsilon4 allele has been associated with elevated levels of cholesterol as well as greater risk of coronary heart disease and Alzheimer's disease. In this case-control study we examined whether apoE genotype affected the association between serum lipids and breast cancer risk. In a subset of a study in western New York, 260 women with incident, primary breast cancer and 332 community controls were interviewed and provided blood samples. Polymerase chain reaction-restriction fragment length polymorphism analyses of the apoE polymorphism were performed. Participants were classified as apoE2 (epsilon2, epsilon2 or epsilon2, epsilon3), apoE3 (epsilon3, epsilon3), or apoE4 (epsilon4, epsilon4 or epsilon4, epsilon3). No unconditional logistic regression was used to compute adjusted odds ratios (ORs) and 95% confidence intervals (CI). Compared with women with the apoE3 genotype, there were no associations with risk for women with the apoE2 (OR=1.0; 95% CI=0. 91-1.64) or apoE4 genotype (OR=0.97; 95% CI=0.63-1.54). Higher serum levels of total cholesterol, HDL cholesterol, and LDL cholesterol were not associated with risk, either in the total sample or among subgroups of women defined by apoE genotype. Women with the highest serum triglyceride levels had an increase in risk (OR=1.63; 95% CI=1. 03-2.59) compared to women with the lowest levels. This effect was not apparent among women with the apoE2 or apoE3 genotype, but much stronger among women with the apoE4 genotype (OR=4.69; 95% CI=1. 49-14.7). These data suggest that the apoE4 genotype may modify the association between serum triglycerides and breast cancer risk.

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Elevated levels of plasma triglycerides are associated with histologically defined piemenopausal breast cancer risk

Cited by 46 publications

References 45 publications

Plasma lipid alterations in African-American women with breast cancer

Plasma lipid alterations in African-American women with breast cancer

The Relationship between Serum Lipids and Breast Cancer in Libya

Apolipoprotein E genetic polymorphism, serum lipoproteins, and breast cancer risk

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