Elevated levels of iodide promote peroxidase-mediated protein iodination and inhibit protein chlorination
Kathrine V. Jokumsen,
Valerie H. Huhle,
Per M. Hägglund
et al.
Abstract:At inflammatory sites, immune cells generate oxidants including H₂O₂. Myeloperoxidase (MPO), released by activated leukocytes employs H₂O₂ and halide/pseudohalides to form hypohalous acids that mediate pathogen killing. Hypochlorous acid (HOCl) is a major species formed. Excessive or misplaced HOCl formation damages host tissues with this linked to multiple inflammatory diseases. Previously (Redox Biology, 2020, 28, 101331) we reported that iodide (I⁻) modulates MPO-mediated protein damage by decreasing HOCl g… Show more
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