1996
DOI: 10.1161/01.cir.94.5.874
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Elevated Levels of Interleukin-6 in Unstable Angina

Abstract: Our study demonstrates that raised levels of interleukin-6 are common in unstable angina, correlate with C-reactive protein, and are associated with prognosis, thus confirming the importance of the cytokine pathway for the production by the liver of acute-phase proteins and strengthening the importance of inflammation in this syndrome. Further studies are required to elucidate better the role of interleukins in unstable angina.

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Cited by 654 publications
(365 citation statements)
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“…7 IL-6 plays a key role in driving the acute inflammatory response and orchestrates the production of acute phase proteins. 8 Elevated levels of IL-6 are found in patients with coronary syndromes 9 and have been associated with increased risk of future myocardial infarction in an apparently healthy population. 10 A relationship between IL-6 and EH may be hypothesised for a number of reasons.…”
Section: Introductionmentioning
confidence: 99%
“…7 IL-6 plays a key role in driving the acute inflammatory response and orchestrates the production of acute phase proteins. 8 Elevated levels of IL-6 are found in patients with coronary syndromes 9 and have been associated with increased risk of future myocardial infarction in an apparently healthy population. 10 A relationship between IL-6 and EH may be hypothesised for a number of reasons.…”
Section: Introductionmentioning
confidence: 99%
“…13,27 IL-6 induces CRP production in hepatocytes and it is the only cytokine that can stimulate the synthesis of all other acute-phase proteins. [28][29][30] Thus, some authors proposed IL-6 as a useful prognostic marker of CVD outcome [31][32][33][34][35][36][37] and suggested a central role for IL-6 in the pathogenesis of CHD. [38][39][40] However, the estimated heritability for IL-6 ranged between 0.17 and 0.57 in the literature 16,41,42 and previous studies concerning the heritability of CRP and IL-6 have to be interpreted carefully (Table 1).…”
mentioning
confidence: 99%
“…In previous studies, plasma CRP levels strongly correlated with those of IL-6, suggesting that measuring CRP may also have been indirectly measuring plasma IL-6 levels. 35,40,62 It was demonstrated that healthy subjects with increased plasma IL-6 levels have a twofold risk of death and CVD events, 32,33 independent of traditional cardiovascular risk factors but additive to that for CRP. 31 Some authors even proposed that elevated plasma IL-6 levels are a stronger predictor of cardiovascular mortality than CRP 63 and IL-6 seems to be the main circulating cytokine in systemic inflammation.…”
mentioning
confidence: 99%
“…Unstable angina is associated with activation of systemic circulating neutrophils 16 and with elevated inflammatory markers such as C-reactive protein and IL-6 levels. [17][18][19] The magnitude of this elevation predicts poor outcome and is not merely secondary to the presence of myocardial necrosis or ischemia. 20 We have recently detected a functional polymorphism 174 bp upstream from the start of transcription of the IL-6 gene.…”
mentioning
confidence: 99%