Elevated levels of decidual insulin‐like growth factor binding protein‐1 in cervical fluid in early and mid‐pregnancy are associated with an increased risk of spontaneous preterm delivery

Rahkonen, Leena; Rutanen, Eeva‐Marja; Nuutila, Mika; Sainio, Susanna; Saisto, Terhi; Paavonen, Jorma

doi:10.1111/j.1471-0528.2010.02551.x

Cited by 20 publications

(22 citation statements)

References 26 publications

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“…Rahkonen et al found that the CVF phIGFBP-1 level of ≥10 ug/l predicts PTL with sensitivities varying from 40.0% to 89.5% and NPVs from 90% to 100% [24]. Rahkonen et al concluded that the elevated phIGFBP1 level in the first trimester was an independent predictor of spontaneous PTL, especially < 32 gestational weeks [24].…”

Section: Discussionmentioning

confidence: 99%

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Diagnostic Accuracy of PremaQuick versus Actim Partus in Prediction of Preterm Labor in Symptomatic Women within 14 Days

Abu-Faza¹,

Abdelazim²,

Svetlana³

et al. 2018

OJOG

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Background: Preterm labor (PTL) remains a major source of neonatal morbidity, and mortality. Currently the trans-vaginal cervical length (TVCL), and/or cervico-vaginal fetal fibronectin (fFN) are the common diagnostic tools used for prediction of PTL. Consequently, many women and their fetuses are exposed unnecessarily tocolysis and hospital admission. Objectives: This study was designed to compare the diagnostic accuracy of PremaQuick versus Actim Partus in prediction of PTL in symptomatic women within 14 days. Patients and Methods: Two-hundred and twenty women (220) were included in this comparative prospective study and classified into two groups: 110 women with threatened preterm labor (TPTL) in the study group, and 110 controls (no TPTL). Women included in the study were subjected to: through history, collection of the cervico-vaginal fluid (CVF) samples for assessment by PremaQuick and Actim Partus tests, followed by trans-vaginal cervical length (TVCL) assessment. Studied women managed according to the hospitals protocol, with follow-up weekly in the obstetrics outpatients' clinic after discharge from the hospital until delivery. The main outcome measures the diagnostic accuracy of PremaQuick versus Actim Partus in prediction of PTL in symptomatic women within 14 days of admission. Results: PremaQuick test was significantly more specific with higher positive predictive value (PPV) in prediction of PTL in symptomatic women within 14 days (95.5% and 89.6%; respectively) compared to CL < 25 mm (56.3% and 54.6%; 742 Open Journal of Obstetrics and Gynecology respectively), (P = 0.02 and 0.03; respectively). In addition, PremaQuick test was significantly more sensitive with higher positive predictive value (PPV) in prediction of PTL in symptomatic women within 14 days (39.8% and 89.6%; respectively) compared to Actim Partus (13.9% and 55.5%; respectively), (P = 0.001 and 0.01; respectively). The Odds ratio and the relative risk for prediction of PTL in symptomatic women within 14 days were significantly high for PremaQuick compared to the CL < 25 mm, and Actim Partus. Conclusion: PremaQuick test seems to be the best complementary test to the CL < 25 in prediction of PTL in symptomatic women within 14 days. PremaQuick test compensates the low specificity and low PPV of the CL < 25 mm in prediction of PTL.

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Section: Discussionmentioning

confidence: 99%

“…Rahkonen et al concluded that the elevated phIGFBP1 level in the first trimester was an independent predictor of spontaneous PTL, especially < 32 gestational weeks [24].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Accuracy of PremaQuick versus Actim Partus in Prediction of Preterm Labor in Symptomatic Women within 14 Days

Abu-Faza¹,

Abdelazim²,

Svetlana³

et al. 2018

OJOG

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“…The roles of IGF-1R in normal and pathological growth and differentiation and aging involve interactions with the ubiquitous growth factors, hormones, and proinflammatory cytokines that are considered to be mediators of the labor process [33]–[35]. Several IGF-binding proteins that regulate IGF-1R–dependent signaling cascades have been studied in the context of SPTB, and some of them have been implicated in preterm labor [36]–[38]. However, these studies did not involve IGF1R and thus the extension of studies involving IGF-1R (particularly the ligand-binding alpha subunit encoded by exons 1–10) to the process of labor, with special consideration of fetal involvement in the endocrine and paracrine control of the preterm labor process, is clearly indicated.…”

Section: Discussionmentioning

confidence: 99%

Mapping a New Spontaneous Preterm Birth Susceptibility Gene, IGF1R, Using Linkage, Haplotype Sharing, and Association Analysis

et al. 2011

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Preterm birth is the major cause of neonatal death and serious morbidity. Most preterm births are due to spontaneous onset of labor without a known cause or effective prevention. Both maternal and fetal genomes influence the predisposition to spontaneous preterm birth (SPTB), but the susceptibility loci remain to be defined. We utilized a combination of unique population structures, family-based linkage analysis, and subsequent case-control association to identify a susceptibility haplotype for SPTB. Clinically well-characterized SPTB families from northern Finland, a subisolate founded by a relatively small founder population that has subsequently experienced a number of bottlenecks, were selected for the initial discovery sample. Genome-wide linkage analysis using a high-density single-nucleotide polymorphism (SNP) array in seven large northern Finnish non-consanginous families identified a locus on 15q26.3 (HLOD 4.68). This region contains the IGF1R gene, which encodes the type 1 insulin-like growth factor receptor IGF-1R. Haplotype segregation analysis revealed that a 55 kb 12-SNP core segment within the IGF1R gene was shared identical-by-state (IBS) in five families. A follow-up case-control study in an independent sample representing the more general Finnish population showed an association of a 6-SNP IGF1R haplotype with SPTB in the fetuses, providing further evidence for IGF1R as a SPTB predisposition gene (frequency in cases versus controls 0.11 versus 0.05, P = 0.001, odds ratio 2.3). This study demonstrates the identification of a predisposing, low-frequency haplotype in a multifactorial trait using a well-characterized population and a combination of family and case-control designs. Our findings support the identification of the novel susceptibility gene IGF1R for predisposition by the fetal genome to being born preterm.

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“…Nine studies provided data on cervicovaginal phosphorylated insulin-like growth factor binding protein-1 (phI-GFBP-1), [65][66][67]69,[72][73][74]77,79 seven studies provided data on relaxin, 34,60,61,70,71,75,78 three studies provided data on cervicovaginal human chorionic gonadotrophin (hCG), 63,68,76 two studies provided data on cervicovaginal prolactin, 62,64 four studies provided data on pregnancy-associated plasma protein-A (PAPP-A), 81,84,85,87 two studies provided data on activin-A, 80,82 and one study each provided data on placental protein-13 (PP13) 83 and pregnancy-specific-b1 glycoprotein (SP1). 86 For cervicovaginal levels of hCG, phIGFBP-1, and prolactin, the pooled sensitivities, specificities, positive and negative LRs to predict preterm birth before 32, 34, and 37 weeks of gestation ranged between 33 and 83% (median, 67%), 62 and 97% (median, 79%), 1.6 and 19.0 (median, 3.2), and 0.2 and 0.8 (median, 0.5), respectively (Table 1).…”

Section: Placental Protein/hormone-related Biomarkersmentioning

confidence: 99%

Novel biomarkers for the prediction of the spontaneous preterm birth phenotype: a systematic review and meta-analysis

Conde-Agudelo

Papageorghiou

Kennedy

et al. 2011

BJOG: An International Journal of Obstetrics &Amp; Gynaecology

145

114

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Background Being able to predict preterm birth is important, as it may allow a high-risk population to be selected for future interventional studies and help in understanding the pathways that lead to preterm birth.Objective To investigate the accuracy of novel biomarkers to predict spontaneous preterm birth in women with singleton pregnancies and no symptoms of preterm labour.Search strategy Electronic searches in PubMed, Embase, Cinahl, Lilacs, and Medion, references of retrieved articles, and conference proceedings. No language restrictions were applied.Selection criteria Observational studies that evaluated the accuracy of biomarkers proposed in the last decade to predict spontaneous preterm birth in asymptomatic women. We excluded studies in which biomarkers were evaluated in women with preterm labour.Data collection and analysis Two reviewers independently extracted data on study characteristics, quality, and accuracy. Data were arranged in 2 · 2 contingency tables and synthesised separately for spontaneous preterm birth before 32, 34, and 37 weeks of gestation. We used bivariate meta-analysis to estimate pooled sensitivities and specificities, and calculated likelihood ratios (LRs).Main results A total of 72 studies, including 89 786 women and evaluating 30 novel biomarkers, met the inclusion criteria. Only three biomarkers (proteome profile and prolactin in cervicovaginal fluid, and matrix metalloproteinase-8 in amniotic fluid) had positive LRs > 10. However, each of these biomarkers was evaluated in only one small study. Four biomarkers had a moderate predictive accuracy (interleukin-6 and angiogenin, in amniotic fluid; human chorionic gonadotrophin and phosphorylated insulin-like growth factor binding protein-1, in cervicovaginal fluid). The remaining biomarkers had low predictive accuracies.Conclusions None of the biomarkers evaluated in this review meet the criteria to be considered a clinically useful test to predict spontaneous preterm birth. Further large, prospective cohort studies are needed to evaluate promising biomarkers such as a proteome profile in cervicovaginal fluid.

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Elevated levels of decidual insulin‐like growth factor binding protein‐1 in cervical fluid in early and mid‐pregnancy are associated with an increased risk of spontaneous preterm delivery

Cited by 20 publications

References 26 publications

Diagnostic Accuracy of PremaQuick versus Actim Partus in Prediction of Preterm Labor in Symptomatic Women within 14 Days

Diagnostic Accuracy of PremaQuick versus Actim Partus in Prediction of Preterm Labor in Symptomatic Women within 14 Days

Mapping a New Spontaneous Preterm Birth Susceptibility Gene, IGF1R, Using Linkage, Haplotype Sharing, and Association Analysis

Novel biomarkers for the prediction of the spontaneous preterm birth phenotype: a systematic review and meta-analysis

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