Elevated Levels of Circulating Soluble Adhesion Molecules in Peripheral Blood of Patients With Unstable Angina

Ghaisas, Nitin K; Shahi, C. N.; Foley, Brendan; Goggins, Michael; Crean, Peter; Kelly, A. K.; Kelleher, Dermot; Walsh, Michael

doi:10.1016/s0002-9149(97)00432-3

Cited by 92 publications

(51 citation statements)

References 5 publications

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“…Intercellular adhesion molecule-1 (ICAM-1, CD54), a transmembrane adhesion molecule expressed on endothelial cells, polymorphonuclear cells and fibroblasts (Kevil & Bullard, 1999). sICAM-1 is the product of proteolytic cleavage of the extracellular region of leukocyte ICAM-1 (Ghaisas et al, 1997) and levels are elevated in patients with coronary vascular disease (CVD) (Ridker et al, 1998). CLA supplementation had no effect on circulating sICAM-1 concentrations in this study group who were young, normolipaemic nonsmokers and had no history of inflammatory conditions.…”

Section: Discussionmentioning

confidence: 99%

The effects of conjugated linoleic acid supplementation on immune function in healthy volunteers

et al. 2005

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Objective: To assess the effects of dietary supplementation using two isomeric blends of conjugated linoleic acid (CLA) on immune function in healthy human volunteers. Design: Double-blind, randomised, placebo-controlled intervention trial. Subjects and intervention: A total of 55 healthy volunteers (n ¼ 20 males, n ¼ 35 females) were randomised into one of three study groups who received 3 g/day of a fatty acid blend containing a 50:50 cis-9, trans-11: trans-10, cis-12 CLA isomer blend (2 g CLA), and 80:20 cis-9, trans-11: trans-10, cis-12 (80:20) CLA isomer blend (1.76 g CLA) or linoleic acid (control, 2 g linoleic acid) for 8 weeks.Results: Supplementation with the 80:20 CLA isomer blend significantly (Pr0.05) enhanced PHA-induced lymphocyte proliferation. CLA decreased basal interleukin (IL)-2 secretion (Pr0.01) and increased PHA-induced IL-2 and tumor necrosis factor a (TNFa) production (Pr0.01). However, these effects were not solely attributable to CLA as similar results were observed with linoleic acid. CLA supplementation had no significant effect on peripheral blood mononuclear cells IL-4 production, or on serum-soluble intercellular adhesion molecule-1 (sICAM-1) or plasma prostaglandin E 2 (PGE 2 ) or leukotreine B 4 (LTB 4 ) concentrations.Conclusions: This study shows that CLA supplementation had a minimal effect on the markers of human immune function. Furthermore, supplementation with CLA had no immunological benefit compared with linoleic acid. Sponsorship: CLA supplements were provided by Loders Croklaan.

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Section: Discussionmentioning

confidence: 99%

The effects of conjugated linoleic acid supplementation on immune function in healthy volunteers

et al. 2005

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“…19) Levels of sICAM-1 in the peripheral blood have been shown to increase within 24 hours of the onset of acute myocardial infarction, 16) and to be significantly higher in patients with unstable angina pectoris than in those with stable angina pectoris or control subjects. 17) In the latter study, there was no significant difference in sICAM-1 plasma levels between the patients with stable angina pectoris and the control subjects. A further study also found no significant association between sICAM-1 plasma levels and the severity of atherosclerosis.…”

Section: Discussionmentioning

confidence: 71%

“…4) Soluble types of these adhesion molecules are thought to be shed from activated cells and can now be measured in peripheral blood. 5) Many studies have reported a relationship between levels of circulating adhesion molecules and coronary artery disease; [6][7][8][9][10][11][12][13][14][15][16][17] however, most investigated levels in peripheral blood. In the present study, we obtained blood samples simultaneously from both the aortic root (Ao) and the coronary sinus (CS), and investigated whether plasma levels of these adhesion molecules in the coronary circulation reflected the severity of coronary atherosclerosis in patients with stable coronary artery disease.…”

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confidence: 99%

<b>Levels of Soluble E-selectin and ICAM-1 in the Coronary Circulation of Patients with Stable Coronary Artery Disease</b>

et al. 2002

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SUMMARYThe recruitment of circulating leukocytes to atherosclerotic sites is mediated by a family of adhesion molecules.The objective of the present study was to evaluate the relationship between circulating adhesion molecule levels in the coronary circulation and the severity of coronary atherosclerosis in patients with stable coronary artery disease.The subjects were 79 patients undergoing coronary angiography. According to the severity of coronary atherosclerosis as assessed by the Gensini Score (GS) of the left coronary artery, they were classified into three groups: group C (no organic stenosis, score 0, n=14), group M (mild organic stenosis, score 1-13, n=39) and group S (severe organic stenosis, score ≥14, n=26). Blood samples were taken from the aorta (Ao) and coronary sinus (CS), and plasma levels of soluble E-selectin (sE-selectin) and soluble intercellular adhesion molecule-1 (sICAM-1) were measured by enzyme-linked immunosorbent assay. These levels were then compared between groups.There were no significant differences in plasma sICAM-1 levels in the Ao or CS between the three groups. The difference in sICAM-1 levels between the CS and Ao (CSAo) also showed no significant difference. Plasma sE-selectin levels in both the Ao and CS were significantly higher in group S than in groups C and M (p<0.05), but there were no significant differences in CS-Ao. There was a weak but significant correlation between the plasma levels of these adhesion molecules and the number of coronary risk factors present. Multivariate analysis showed that the number of coronary risk factors was the only positive predictor (p=0.0048) of the GS; there was no association between the plasma level of either adhesion molecule and the GS.In patients with stable coronary artery disease, sICAM-1 plasma levels do not indicate the severity of coronary atherosclerosis, while sE-selectin plasma levels appear to reflect the severity of systemic rather than coronary atherosclerosis. (Jpn Heart J 2002; 43: 93-101) From the

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“…This association was independent of other risk factors, including the nonspecific inflammatory indicator C-reactive protein, and, in a multivariable model, sVCAM-1 was the only independently predictive soluble cell adhesion molecule. 45 Several authors [46][47][48][49] have reported increased levels of sICAM-1 and sVCAM-1 in cohorts with unstable coronary heart disease. Nevertheless, subtle differences are once again apparent.…”

Section: Soluble Icam-1 and Vcam-1 As Prognostic Markersmentioning

confidence: 99%

“…Nevertheless, subtle differences are once again apparent. For example, investigators from Dublin have consistently shown significantly higher levels of sVCAM-1 in patients with unstable angina, as compared to healthy controls, 46,47 whereas others have failed to replicate these findings. 49 There are also differences in the reported prognostic value of soluble cell adhesion molecules in this setting, with one study suggesting that sVCAM-1 (but not sICAM-1) levels are useful early prognostic indicators, 50 but others reporting no prognostic value, 49 particularly in more heterogeneous cohorts.…”

Section: Soluble Icam-1 and Vcam-1 As Prognostic Markersmentioning

confidence: 99%

Soluble integrin adhesion receptors and atherosclerosis: much heat and a little light?

Hillis

2003

J Hum Hypertens

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Elevated Levels of Circulating Soluble Adhesion Molecules in Peripheral Blood of Patients With Unstable Angina

Cited by 92 publications

References 5 publications

The effects of conjugated linoleic acid supplementation on immune function in healthy volunteers

The effects of conjugated linoleic acid supplementation on immune function in healthy volunteers

<b>Levels of Soluble E-selectin and ICAM-1 in the Coronary Circulation of Patients with Stable Coronary Artery Disease</b>

Soluble integrin adhesion receptors and atherosclerosis: much heat and a little light?

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