Elevated levels of basic fibroblast growth factor in the cerebrospinal fluid of patients with moyamoya disease.

明弘, 高橋; 清博, 宝金; 博康, 上山; 豊, 沢村; 弘, 阿部

doi:10.3995/jstroke.16.201

Cited by 5 publications

(2 citation statements)

References 13 publications

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“…Other investigators have also reported this phenomenon. 43,44 This time gap between clinical and angiographic improvement is explained by formation of granulation starting within 1 day after injury, as has been shown in rabbit microangiograms. 44 Before neovascularization becomes visible on angiography, volume sufficient to improve the clinical symptoms would flow into the cortex.…”

Section: Time To Clinical Improvementmentioning

confidence: 91%

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Multiple burr-hole operation for adult moyamoya disease

Kawaguchi

Fujita²,

Hosoda³

et al. 1996

Journal of Neurosurgery

112

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Excellent results from multiple burr-hole operations for adult moyamoya disease are reported in this study. Ten patients had between one and four burr holes (mean 2.1) drilled in each hemisphere. In four patients new burr holes were added on the opposite side after depression of cerebral blood flow (CBF) was detected by follow-up single-photon emission computerized tomography imaging of the brain with N-isopropyl-p-[123I]iodoamphetamine. The postoperative follow-up period ranged from 6 to 62 months (mean 34.7 months). Beginning at 6 months postsurgery, angiograms disclosed rich neovascularization at 41 of 43 burr holes, first from the middle meningeal artery, then from the superficial temporal artery. Neovascularization did not occur at two burr holes at which there was subdural effusion and local cerebral atrophy, respectively. Progression of stenosis of the major vessels was seen in six patients. Moyamoya vessels were decreased at six sites in four patients. The CBF study revealed that the reactivity to acetazolamide improved in all six patients tested. Transient ischemic attacks disappeared in all six patients presenting with this symptom, and preoperative symptoms improved in both of the patients who presented with cerebral infarction and in both patients with intraventricular hemorrhage. There was no mortality or morbidity, and no new neurological deficits or rebleeding developed during the follow-up period. The authors strongly recommend the multiple burr- hole operation as the surgical treatment of choice for adult moyamoya disease because of its safety and effectiveness.

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Section: Time To Clinical Improvementmentioning

confidence: 91%

“…The third factor is the presence of chemicals such as the angiogenetic factor that induce angiogenesis. 7,36,37,43 We performed a burr-hole operation for an elderly patient with atherosclerosis and misery perfusion, but no neovascularization occurred. This suggests the existence of an angiogenetic factor.…”

Section: Factors Preventing Neovascularizationmentioning

confidence: 99%

Multiple burr-hole operation for adult moyamoya disease

Kawaguchi

Fujita²,

Hosoda³

et al. 1996

Journal of Neurosurgery

112

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Arteriovenous malformation associated with moyamoya disease

et al. 1996

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The first case of a child with an arteriovenous malformation (AVM) associated with moyamoya disease is reported. The patient presented ischemic symptoms and underwent indirect bypass surgery on both sides when she was 5 years old. Four years later she suffered from headache, and a small AVM of the left frontal lobe associated with the moyamoya vessels was detected. Single photon emission computed tomography (SPECT) was performed at age 11 and demonstrated low local cerebral blood flow (CBF) in the left frontal lobe and right temporal lobe, although the revascularization after the bypass surgery seemed to be effective, as judged on pancerebral angiography. We feel that brain ischemia due to the moyamoya disease may have played a causative role in the development of the AVM.

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