Elevated levels of alanine transaminase and triglycerides within normal limits are associated with fatty liver

Abstract

In the present study, the threshold values of laboratory data for the diagnosis of non-alcoholic fatty liver disease (NAFLD) were investigated. The study enrolled patients who had undergone abdominal ultrasound (US) between April 2013 and August 2013, and for whom laboratory data were available on the same day. NAFLD was diagnosed following observations of a bright liver or hepatorenal echo contrast on the abdominal US scans. Patients were excluded from the study if they had liver diseases or had been prescribed prednisolone or methotrexate. Receiver operating characteristic curves, the Wilcoxon signed-rank test and Fisher’s exact probability test were used for data analysis. In total, 80 NAFLD and 94 non-NAFLD patients were enrolled in the study. The threshold levels of alanine aminotransferase (ALT) and triglyceride (TG) for the diagnosis of NAFLD were 19.0 IU/l and 101 mg/dl, respectively. Patients were divided into two groups according to the levels of ALT and TG. Those with ALT levels of >19 IU/l and TG levels of >101 mg/dl were defined as the positive group, while the remaining patients were classified as the negative group. The specificity and positive predictive value using the combined threshold levels of ALT >19 IU/l and TG >101 mg/dl were 80.9 and 75.0%, respectively. Therefore, the results indicated that ALT levels of >19 IU/l or TG levels of >101 mg/dl were useful markers for the screening of NAFLD. However, NAFLD was more strongly suspected in patients with ALT levels of >19 IU/l and TG levels of >101 mg/dl.

Association between colon diverticula and hemoglobin, triglyceride and uric acid levels

“…Higher TG levels are associated with metabolic syndrome (16,17) and TG level decreases as metabolic syndrome improves following lifestyle changes (18). In the present study, high TG levels were associated with diverticula.…”

Branched-Chain Amino Acid Levels Are Related with Surrogates of Disturbed Lipid Metabolism among Older Men

“…The findings on the association between recent high physical activity level and reduced levels of BCAAs are in agreement with recent data (9). Of the commonly used serum analytes reflecting liver function, serum alkaline phosphatase, and γ-glutamyltransferase have been shown to be most strongly related to the occurrence of non-alcoholic fatty liver disease NAFLD (20). Serum BCAA concentrations associated with these analytes.…”

Impacto del Programa de manejo de la obesidad Bright Bodies aplicado a niños y adolescentes chilenos

“…La ALT, utilizada como marcador de enfermedad hepática no alcohólica cuando se encuentra a altas concentraciones, se redujo sin alcanzar niveles de significancia, al igual que lo demostrado por Savoye et al 9 . Recientemente, se ha informado que niveles de ALT mayores de 19 UI/L y de triglicé-ridos mayores de 101 mg/dL se encuentran estrechamente relacionados con enfermedad hepática no alcohólica 18 . Estos parámetros en los niños y adolescentes eran superiores a dichos valores antes de participar en el Programa Bright Bodies, y disminuyeron siendo menores a las concentraciones antes mencionadas al término de los 8 meses.…”