1987
DOI: 10.1002/j.1460-2075.1987.tb02461.x
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Elevated levels of a specific class of nuclear phosphoproteins in cells transformed with v-ras and v-mos oncogenes and by cotransfection with c-myc and polyoma middle T genes.

Abstract: Transformation of a rat thyroid epithelial cell line (FRTL5-C12) with Kirsten and Harvey murine sarcoma viruses (carrying the ras oncogenes) results in elevated levels of three perchloric acid-soluble nuclear phosphoproteins. These three proteins are also induced to high levels in the PC-C13 thyroid epithelial cell line when transformed by the myeloproliferative sarcoma virus (carrying the v-mos oncogene) and when transformed by transfection with the c-myc proto-oncogene followed by infection with the polyoma … Show more

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Cited by 153 publications
(136 citation statements)
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“…Indeed, increased HMGA levels correlate with the appearance of a malignant phenotype in rat thyroid cells and in experimental thyroid and skin tumours. [7][8][9] HMGA1 levels are high in human thyroid, 10,11 colon, [12][13][14] prostate, 15 pancreas, 16 cervix, 17 ovary 18 and breast 19 carcinomas. We had previously demonstrated that overexpression of HMGA proteins is required for cell transformation, since the blockage of their synthesis prevents tumorigenic transformation of rat thyroid cells by murine transforming retroviruses.…”
Section: Introductionmentioning
confidence: 99%
“…Indeed, increased HMGA levels correlate with the appearance of a malignant phenotype in rat thyroid cells and in experimental thyroid and skin tumours. [7][8][9] HMGA1 levels are high in human thyroid, 10,11 colon, [12][13][14] prostate, 15 pancreas, 16 cervix, 17 ovary 18 and breast 19 carcinomas. We had previously demonstrated that overexpression of HMGA proteins is required for cell transformation, since the blockage of their synthesis prevents tumorigenic transformation of rat thyroid cells by murine transforming retroviruses.…”
Section: Introductionmentioning
confidence: 99%
“…Indeed, elevated expression of HMGI proteins correlates with the appearance of a malignant phenotype in rat thyroid transformed cells and in thyroid and skin experimental tumours (Giancotti et al, 1985(Giancotti et al, , 1987(Giancotti et al, , 1989. Similarly, HMGI(Y) protein levels are high in such human carcinomas as thyroid (Chiappetta et al, 1995(Chiappetta et al, , 1998, colon Abe et al, 1999;Chiappetta et al, 2001), prostate (Tamimi et al, 1993), pancreas (Abe et al, 2000) and cervix (Bandiera et al, 1998), but not in their normal counterparts.…”
Section: Introductionmentioning
confidence: 99%
“…HMGI-C and HMGI(Y) are members of the HMGI family of "highmobility group" (HMG) proteins. They act as architectural transcription factors and are commonly expressed in embryonal cells Hirning-Folz et al, 1998), in transformed cells with a malignant phenotype Bussemakers et al, 1991;Giancotti et al, 1987;1989;Ram et al, 1993), and in a variety of human cancers (Bandiera et al, 1998;Chiappetta et al, 1995;1998;Fedele et al, 1996;Rogalla et al, 1997;Rommel et al, 1997;Tamimi et al, 1993). HMGI-C and HMGI(Y) genes are located at 12q15 and 6p21 (Friedmann et al, 1993), respectively.…”
mentioning
confidence: 99%