Elevated leukocyte count and adverse hospital events in patients with acute coronary syndromes: findings from the global registry of acute coronary events (grace)

Do circulating blood cell types correlate with modifiable risk factors and outcomes in patients with acute coronary syndrome (ACS)?

“…38 Investigators of GRACE study examined the relationship between leukocyte count and hospital events among patients presented with an ACS. 39 In the same line, our study group also showed strongly association of mortality with circulating inflammatory markers.…”

Levels of High-Density Lipoprotein Cholesterol are Associated With Biomarkers of Inflammation in Patients With Acute Coronary Syndrome

“…These inflammatory biomarkers were dichotomized according to previously established cut-offs. [11][12][13] Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated for variables in both univariate and multivariate analyses. Separate regression models were estimated for STEMI and NSTE-ACS.…”

Does smoking status affect the association between baseline white blood cell count and in-hospital mortality of patients presented with Acute Coronary Syndrome? The Greek study of Acute Coronary Syndromes (GREECS)

“…For example, investigators of GRACE study examined the relationship between leukocyte count and hospital events, among patients presented with an ACS. The investigators showed that patients with WBC count N 12,000 cells/dL were 2.8 times more likely to die in-hospital and 2.7 times to develop heart failure compared to those with WBC count: 6000-9999 cells/dL [17]. Barron et al, showed that among patients with MI those in the highest quantile of WBC count were 3 times more likely to die at 30 days after discharge than those in the lowest quantile [32].…”

“…Moreover, elevated WBC count may be a risk factor for adverse clinical outcome after coronary intervention or coronary artery bypass grafting [8][9][10][11][12][13] and after acute myocardial infarction (AMI) [14][15][16]. However, data about the association of WBC count and in-hospital mortality in patients hospitalized with Acute Coronary Syndrome (ACS) are limited [17]. WBC count has, also, been associated with several cardiovascular (CVD) risk factors including serum cholesterol, triglycerides, and cigarette smoking [18][19][20].…”