Elevated Inflammatory Status and Increased Risk of Chronic Disease in Chronological Aging: Inflamm-aging or Inflamm-inactivity?

Flynn, Michael G.; Markofski, Melissa M.; Carrillo, Andres E.

doi:10.14336/ad.2018.0326

Cited by 91 publications

(83 citation statements)

References 92 publications

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“…In particular, we observed the reduction of IL-8, TNF-α, RANTES, and PDGF-b in Bedridden with respect to Old individuals, and increased serum levels of IL-1β and GM-CSF in the Bedridden with respect to both the Old and Young, as well as the increased levels of IFN-γ in the serum of the Bedridden only compared to that of the Young. All these data support a complex alteration and/or activation of pro-and anti-inflammatory responses due to inactivity, which was previously partially explained as "inflamm-aging" able to induce a hyper-inflammatory state commonly found associated with aging [30]. These findings suggest that a complex regulation of inflammatory reactions may occur in the Bedridden condition, possibly reflecting a complex modulation of innate and adaptive immune responses, and requires further and more in depth cell and molecular studies.…”

Section: Evidence That Physical Constraint Affects Vascular-related Isupporting

confidence: 79%

The Vascular Side of Chronic Bed Rest: When a Therapeutic Approach Becomes Deleterious

Pedrinolla

Colosio

Magliozzi

et al. 2020

JCM

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The interplay between chronic constraint and advanced aging on blood flow, shear-rate, vascular function, nitric oxide (NO)-bioavailability, microcirculation, and vascular inflammation factors is still a matter of debate. Ninety-eight individuals (Young, n = 28, 23 ± 3 yrs; Old, n = 36, 85 ± 7 yrs; Bedridden, n = 34, 88 ± 6 yrs) were included in the study. The bedridden group included old individuals chronically confined to bed (3.8 ± 2.3 yrs). A blood sample was collected and analyzed for plasma nitrate, and vascular inflammatory markers. Hyperemic response (∆peak) during the single passive leg movement (sPLM) test was used to measure vascular function. Skeletal muscle total hemoglobin was measured at the vastus lateralis during the sPLM test, by means of near infrared spectroscopy (NIRS). Bedridden subjects revealed a depletion of plasma nitrates compared with Old (−23.8%) and Young (−31.1%). Blood flow was lower in the Bedridden in comparison to Old (−20.1%) and Young (−31.7%). Bedridden presented lower sPLM ∆peak compared Old (−72.5%) and the Young (−83.3%). ∆peak of NIRS total hemoglobin was lower in the Bedridden compared to that in the Young (−133%). All vascular inflammatory markers except IL-6 were significantly worse in the Bedridden compared to Old and Young. No differences were found between the Old and Young in inflammatory markers. Results of this study confirm that chronic physical constraint induces an exacerbation of vascular disfunction and differential regulation of vascular-related inflammatory markers. The mechanisms involved in these negative adaptations seems to be associated with endothelial dysfunction and consequent diminished NO-bioavailability likely caused by the reduced shear-rate consequential to long-term reduction of physical activity.

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Section: Evidence That Physical Constraint Affects Vascular-related Isupporting

confidence: 79%

The Vascular Side of Chronic Bed Rest: When a Therapeutic Approach Becomes Deleterious

Pedrinolla

Colosio

Magliozzi

et al. 2020

JCM

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“…This nding agrees with other's scholars work [61]. This is due to the fact that serum iron decreasing factors like chronic diseases and other unhealthy lifestyles were prevalent as the age increases [62].…”

Section: Discussionsupporting

confidence: 92%

Micronutrient levels and their effect on the prognosis of visceral leishmaniasis treatment; a prospective cohort study.

Feleke

2020

Preprint

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Background: Micronutrients are minerals and vitamins required in small amounts, and they are essential for normal physiological activities. The objectives of the study were to describe the progress and determinants of micronutrients level and to assess the effect of micronutrients in the treatment outcomes. Methods: A prospective cohort study was implemented. The data were collected using interviews, measuring anthropometric indicators, collecting blood, urine, and stool samples from each patient. The blood samples were collected five times: before starting anti-leishmaniasis treatments, in the first week, in the second week, in the third week, and in the 4th week of anti-leishmaniasis treatments. Descriptive statistics were used to describe the profile of patients and to compare the treatment success rate of visceral leishmaniasis patients. The generalized estimating equation was used to identify the determinants of serum micronutrients.Results: The serum zinc level of visceral leishmaniasis patients was affected by alcohol, DDS, family size, HIV, and sex. The serum iron level of visceral leishmaniasis patients were affected by alcohol, family size, malaria, hookworm, chronic diseases, and HIV. The serum selenium level of visceral leishmaniasis patients was affected by HIV and family size. The iodine level of visceral leishmaniasis patients was affected by HIV, DDS, smoking, chronic illness, and regular physical exercise. The serum vitamin D level of visceral leishmaniasis patients was affected by HIV, alcohol, chronic illness, DDS, malaria, family size, age, residence, and MUAC. The serum vitamin D level of visceral leishmaniasis patients was affected by BMI, DDS, malaria, hookworm, family size, HIV, and age. Conclusion: The Micronutrient levels of visceral leishmaniasis patients were significantly low. Anti-leishmaniasis treatment did not increase the serum micronutrient levels of the patients.

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“…A similar SI process that is associated with aging is called inflammaging (Flynn et al, 2019). SI is considered an adaptive response that causes systemic damage, leading to the development of multiple pathologies, including CVDs (Oishi and Manabe, 2016).…”

Section: Inflammatory Alterations In Ckd and Their Relationship Withmentioning

confidence: 99%

Mechanisms of Cardiovascular Disorders in Patients With Chronic Kidney Disease: A Process Related to Accelerated Senescence

Carracedo

Alique

Vida

et al. 2020

Front. Cell Dev. Biol.

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Cardiovascular diseases (CVDs), especially those involving a systemic inflammatory process such as atherosclerosis, remain the leading cause of morbidity and mortality in patients with chronic kidney disease (CKD). CKD is a systemic condition affecting approximately 10% of the general population. The prevalence of CKD has increased over the past decades because of the aging of the population worldwide. Indeed, CVDs in patients with CKD constitute a premature form of CVD observed in the general population. Multiple studies indicate that patients with renal disease undergo accelerated aging, which precipitates the appearance of pathologies, including CVDs, usually associated with advanced age. In this review, we discuss several aspects that characterize CKD-associated CVDs, such as etiopathogenic elements that CKD patients share with the general population, changes in the cellular balance of reactive oxygen species (ROS), and the associated process of cellular senescence. Uremiaassociated aging is linked with numerous changes at the cellular and molecular level. These changes are similar to those observed in the normal process of physiologic aging. We also discuss new perspectives in the study of CKD-associated CVDs and epigenetic alterations in intercellular signaling, mediated by microRNAs and/or extracellular vesicles (EVs), which promote vascular damage and subsequent development of CVD. Understanding the processes and factors involved in accelerated senescence and other abnormal intercellular signaling will identify new therapeutic targets and lead to improved methods of diagnosis and monitoring for patients with CKD-associated CVDs.

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Elevated Inflammatory Status and Increased Risk of Chronic Disease in Chronological Aging: Inflamm-aging or Inflamm-inactivity?

Cited by 91 publications

References 92 publications

The Vascular Side of Chronic Bed Rest: When a Therapeutic Approach Becomes Deleterious

The Vascular Side of Chronic Bed Rest: When a Therapeutic Approach Becomes Deleterious

Micronutrient levels and their effect on the prognosis of visceral leishmaniasis treatment; a prospective cohort study.

Mechanisms of Cardiovascular Disorders in Patients With Chronic Kidney Disease: A Process Related to Accelerated Senescence

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