Elevated Inflammatory Markers in Response to Prolonged Sleep Restriction Are Associated With Increased Pain Experience in Healthy Volunteers

Haack, Monika; Sánchez, Elsa Yolanda; Mullington, Janet

doi:10.1093/sleep/30.9.1145

Cited by 496 publications

(365 citation statements)

References 46 publications

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“…Associations between inflammation, sleep loss and psychological symptoms are well documented in a variety of conditions [14,27,28,31,38,46,70]. Although the interrelationships are not fully understood, abnormal hypothalamic-pituitary adrenal-axis (HPA-axis) function has emerged as a possible explanation [27].…”

Section: Relationship Between Cytokine/crp Levels and Non-pain Factorsmentioning

confidence: 99%

Systemic inflammatory profiles and their relationships with demographic, behavioural and clinical features in acute low back pain

Klyne

Barbe

Hodges

2017

Brain, Behavior, and Immunity

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Please cite this article as: Klyne, D.M., Barbe, M.F., Hodges, P.W., Systemic inflammatory profiles and their relationships with demographic, behavioural and clinical features in acute low back pain, Brain, Behavior, and Immunity (2016), doi: http://dx.doi.org/10. 1016/j.bbi.2016.10.003 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. and control participants, and in a separate analysis, for those with "high-pain" (VAS≥4) and "low-pain" (VAS<4). The relationships between biomarkers and all other variables, including other cytokines/CRP were assessed. CRP was higher in LBP than controls and in those with high-than low-pain (p<0.01). IL-6 was higher in those with high-than low-pain (p<0.05), but not controls. Various pain and non-pain factors were associated with each biomarker differently. These findings suggest systemic CRP and IL-6 are important contributors to inflammation in the early post-onset phase of LBP and that various factors can shape these responses.3

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Section: Relationship Between Cytokine/crp Levels and Non-pain Factorsmentioning

confidence: 99%

Systemic inflammatory profiles and their relationships with demographic, behavioural and clinical features in acute low back pain

Klyne

Barbe

Hodges

2017

Brain, Behavior, and Immunity

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“…One possible explanation is that pain at night is a characteristic of shoulder disorders, which could influence sleep habits. On the contrary, sleep disturbance provoked low-level systemic inflammation with more sensitive nociception, which could cause shoulder pain in survivors (Haack et al 2007;Mork et al 2014). These complex scenarios could cause both sleep disturbance and shoulder pain in the participants.…”

Section: Discussionmentioning

confidence: 99%

Association Between Sleep Disturbance and New-onset Subjective Shoulder Pain in Survivors of the Great East Japan Earthquake: A Prospective Cohort Study in Miyagi Prefecture

Hagiwara

Sekiguchi

Sugawara

et al. 2017

Tohoku J. Exp. Med.

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“…It is well established that pain hinders sleep and disturbed sleep lowers pain threshold. [17][18][19] Whether SLD precedes or follows pain onset is unclear, but reciprocal effects are likely. 17 Even after treatment with anti-inflammatory medications, patients with OA show significantly greater objective SLD, as compared with age-matched control subjects.…”

Section: Discussionmentioning

confidence: 99%

Effects of Balneotherapy and Physical Therapy on Sleep Quality in Patients with Osteoarthritis Aged 50 to 85 Years

et al. 2016

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Objectives: This study aims to investigate the effect of balneotherapy (BT) and physical therapy (PT) on sleep quality in patients with knee osteoarthritis (OA) aged 50 to 85 years. Patients and methods: A total of 199 patients (76 males, 123 females; mean age 67.8±7.3 years; range 50 to 85 years) suffering from knee OA (Kellgren-Lawrence grade 2-3) for more than six months were enrolled. Sleep and functional status were assessed at baseline and after 19 sessions of BT and 15 sessions of PT by using Pittsburgh Sleep Quality Index and Western Ontario and McMaster Universities Osteoarthritis Index, respectively. Results: A high prevalence of abnormal sleep quality in patients with knee OA was observed. The most common abnormality was sleep fragmentation (71%), with an increased sleep disturbance score. Patients reported significantly improved sleep, pain, stiffness, and functional status after BT and PT. Conclusion: Balneotherapy and PT improved self-reported sleep and functional status in patients with OA aged 50 to 85 years. We may conclude that BT and PT, which are used in the treatment of OA, not only reduce nocturnal pain, but also improve sleep quality.

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Elevated Inflammatory Markers in Response to Prolonged Sleep Restriction Are Associated With Increased Pain Experience in Healthy Volunteers

Abstract: Insufficient sleep quantity may facilitate and/or exacerbate pain through elevations of IL-6. In disorders where sleep disturbances are common, insufficient sleep quantity itself may establish and maintain its co-occurrence with pain and increased inflammation.

Cited by 496 publications

References 46 publications

Systemic inflammatory profiles and their relationships with demographic, behavioural and clinical features in acute low back pain

Systemic inflammatory profiles and their relationships with demographic, behavioural and clinical features in acute low back pain

Association Between Sleep Disturbance and New-onset Subjective Shoulder Pain in Survivors of the Great East Japan Earthquake: A Prospective Cohort Study in Miyagi Prefecture

Effects of Balneotherapy and Physical Therapy on Sleep Quality in Patients with Osteoarthritis Aged 50 to 85 Years

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