Elevated Hydrogen Sulfide Levels in Vitreous Body and Plasma in Patients With Proliferative Diabetic Retinopathy

Ran, Ruijin; Du, Liping; Zhang, Xuedong; Chen, Xiaoli; Fang, Yanhong; Li, Yingyuan; Tian, Hongyi

doi:10.1097/iae.0000000000000184

Cited by 21 publications

(19 citation statements)

References 31 publications

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“…29,30 Others describe that H 2 S may promote apoptosis of aortic smooth muscle cells, 31 and scavenges peroxynitrite 32 which contribute to the nitrosative stress, 33 and consequently to endothelial damage associated with this condition. 34 In our experiments, the T1D mice, non-obese, non-overweight and exhibiting an early Class I (like) diabetic nephropathy, exhibited elevated levels of plasma H 2 S ( Figure 1C,D), as reported for patients with proliferative diabetic retinopathy 34,35 and cardiovascular disease. 36 It is important to emphasize that the amplified level of H 2 S was present in the renal cortex of T1D animals.…”

Section: Discussionsupporting

confidence: 78%

Diabetic nephropathy associates with deregulation of enzymes involved in kidney sulphur metabolism

Uyy¹,

Suica²,

Boteanu³

et al. 2020

J Cellular Molecular Medi

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Type 1 diabetes (T1D) are characterized by a targeted autoimmune destruction of the insulin-producing β-cells in the pancreatic islets of Langerhans and the ensuing insufficient insulin production. The different degrees of β-cell dysfunction lead to chronic hyperglycaemia accompanied by an inflammatory reaction and immune responses that affect major organs including eyes, nerves, heart, blood vessels and kidneys. A major feature of diabetic kidney disease is the apoptosis of tubular epithelial cells as a result of increased free radicals production and amplified oxidative stress under the hyperglycaemic condition. 1 Most of the current studies on T1D use animal models that promptly develop severe disease after administration of diabetogenic substances, such as streptozotocin or alloxan. 2 To address the early

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Section: Discussionsupporting

confidence: 78%

Diabetic nephropathy associates with deregulation of enzymes involved in kidney sulphur metabolism

Uyy¹,

Suica²,

Boteanu³

et al. 2020

J Cellular Molecular Medi

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“…H 2 S is a known proangiogenic signaling molecule and can thereby also contribute to enhanced angiogenesis in the diabetic retina. In line with this, increased levels of H 2 S were observed in vitreous body of patients with proliferative diabetic retinopathy compared with patients with rhegmatogenous retinal detachment (94). The effects of H 2 S in the diabetic retina are schematically shown in Fig.…”

Section: Hydrogen Sulfide and Microvascular Complications Of Diabetessupporting

confidence: 61%

Gasotransmitters in Vascular Complications of Diabetes

et al. 2016

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In the past decades three gaseous signaling molecules—so-called gasotransmitters—have been identified: nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S). These gasotransmitters are endogenously produced by different enzymes in various cell types and play an important role in physiology and disease. Despite their specific functions, all gasotransmitters share the capacity to reduce oxidative stress, induce angiogenesis, and promote vasorelaxation. In patients with diabetes, a lower bioavailability of the different gasotransmitters is observed when compared with healthy individuals. As yet, it is unknown whether this reduction precedes or results from diabetes. The increased risk for vascular disease in patients with diabetes, in combination with the extensive clinical, financial, and societal burden, calls for action to either prevent or improve the treatment of vascular complications. In this Perspective, we present a concise overview of the current data on the bioavailability of gasotransmitters in diabetes and their potential role in the development and progression of diabetes-associated microvascular (retinopathy, neuropathy, and nephropathy) and macrovascular (cerebrovascular, coronary artery, and peripheral arterial diseases) complications. Gasotransmitters appear to have both inhibitory and stimulatory effects in the course of vascular disease development. This Perspective concludes with a discussion on gasotransmitter-based interventions as a therapeutic option.

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“…Plasma H 2 S levels in the patients as well as control subjects in our study are comparable with earlier studies which is within the range of 10 to100 micromol/l in human subjects. 5 Elevated hydrogen sulfide levels in plasma were also reported in patients with proliferative diabetic retinopathy 20 as well as patients with cardiovascular disease 21 cerebral ischaemic damage 22 and septic shock 23 M. Yusuf et al has earlier reported that the streptozotocin-induced diabetes in rat is associated with enhanced tissue hydrogen sulfide biosynthesis. 17 The activities of H 2 S producing enzymes and the tissue H 2 S contents are known to increase under diabetic conditions.…”

Section: Resultsmentioning

confidence: 99%

Enhanced Plasma H2S Levels Associated With Fasting Blood Glucose In Type-2 Diabetes Mellitus

et al. 2015

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Introduction: A number of recent literatures suggest a potential role of H 2 S and H 2 S modifying agents in the etiology and management of type-2 diabetes mellitus. Objective: The current study was aimed to evaluate the plasma levels of H 2 S in the patients with type 2 Diabetes mellitus and to find out if there is any relationship of H 2 S concentrations with the fasting blood glucose levels. Methods: Plasma H 2 S levels were measured in sixty two recently diagnosed type 2 diabetic patients and compared with similar number of healthy volunteers as controls. Results: The plasma H 2 S level in the patients (81.17 ± 16.40 micromol/l) is significantly higher (P< 0.001) than the healthy controls (50.69 ± 8.69 micromol/l) and the H 2 S levels in plasma have significant positive correlation (r= 0.359, P=0.004) with fasting blood glucose levels. Conclusion: The present study has elucidated that the patients with type-2 diabetes mellitus are associated with elevated plasma H 2 S levels which are well correlated with glucose levels. This reveals a potential role of H 2 S modulators towards the management of this non-communicable epidemic disorder.

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Elevated Hydrogen Sulfide Levels in Vitreous Body and Plasma in Patients With Proliferative Diabetic Retinopathy

Abstract: These results indicated that anti-vascular endothelial growth factor may downregulate the H2S level in the vitreous body, and H2S may play a role in the development of DR. Hydrogen sulfide may be a novel target for the therapy of DR.

Cited by 21 publications

References 31 publications

Diabetic nephropathy associates with deregulation of enzymes involved in kidney sulphur metabolism

Diabetic nephropathy associates with deregulation of enzymes involved in kidney sulphur metabolism

Gasotransmitters in Vascular Complications of Diabetes

Enhanced Plasma H2S Levels Associated With Fasting Blood Glucose In Type-2 Diabetes Mellitus

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