Elevated High Sensitivity C‐Reactive Protein Increases the Risk of Microalbuminuria in Subjects With Cardiovascular Disease Risk Factors

Yang, Shikun; Liu, Jun; Yi, Bin; Mao, Juan; Zhang, Xianming; Liu, Yan; Lei, Dandan; Gui, Ming; Zhang, Hao

doi:10.1111/1744-9987.12530

Cited by 8 publications

(5 citation statements)

References 40 publications

(40 reference statements)

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“…Microalbuminuria was also more common in smokers with high hs-CRP than in smokers with normal hs-CRP. Similar finding was also found in obese subjects with high hs-CRP compared to non-obese subjects with normal hs-CRP (Yang et al, 2017). A research in Singapore showed that people with CRP levels of >3 mg/L were 1.6 times more likely to develop micro-and macroalbuminuria than people with CRP levels of <1 mg/L (odds ratio=1.60; 95% CI: 1.26-2.04; p=0.0001) (Sabanayagam et al, 2009).…”

Section: Discussionsupporting

confidence: 70%

“…In addition, elevated CRP also promotes overproduction of pro-inflammatory cytokines, then leads to glomerular mesangial cell proliferation and increases in renal vascular permeability, eventually resulting in albuminuria. There is a close relationship between inflammation and activation of the renin-angiotensin system and oxidative stress, leading to glomerular hyperfiltration and albuminuria (Yang et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

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Correlation between Serum High-Sensitivity C-Reactive Protein Level and Severity of Albuminuria Measured by Urine Albumin-to-Creatinine Ratio in Type 2 Diabetic Patients

Febrianto,

Soelistijo,

Tjempakasari

2023

CIMRJ

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Introduction: One of complications in type 2 diabetes mellitus (DM) that require high treatment cost is diabetic kidney disease (DKD), which is characterized by the presence of albuminuria, decrease in glomerular filtration rate, or both. Researches show a positive correlation between type 2 DM and serum high-sensitivity C-reactive protein (hs-CRP) level, a sensitive marker of subclinical inflammation. This study aimed to analyze the correlation between serum hs-CRP level and severity of albuminuria measured by urine albumin-to-creatinine ratio (ACR).Methods: The study was conducted at the Endocrinology Outpatient Clinic of Dr. Soetomo General Academic Hospital, Surabaya, on June-July 2020.Results: The study included 50 patients with type 2 DM, consisting of 25 (50%) men and 25 (50%) women, with median age of 58.0 (42-68) years and mean body mass index (BMI) of 21.91 ± 1.310 kg/m2. Median duration of DM was 12.0 (6-22) years, median HbA1c level was 7.20% (5.7%-12.3%), mean serum crEatinine level was 0.83 ± 0.180 mg/dL, and median estimated glomerular filtration rate (eGFR) value was 92.85 (61.6-121.2) mL/minute/1.73 m2. Median serum hs-CRP level was 1.20 (0.1-4.0) mg/L and median urine ACR value was 49.570 (7.78-426.00) mg/g. Normoalbuminuria was detected in 28% of subjects, microalbuminuria in 66% of subjects, and macroalbuminuria in 6% of subjects. This study showed positive and significant correlation between serum hs-CRP level and severity of albuminuria (r = 0.701; p = <0.001).Conclusion: There was positive and significant correlation betweeen serum hs-CRP level and severity of albuminuria in type 2 diabetic patients.

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Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Correlation between Serum High-Sensitivity C-Reactive Protein Level and Severity of Albuminuria Measured by Urine Albumin-to-Creatinine Ratio in Type 2 Diabetic Patients

Febrianto,

Soelistijo,

Tjempakasari

2023

CIMRJ

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“…In this way, early intervention can help prevent kidney disease. 50,51 Also, the progression of diabetic nephropathy can be insidious and lead to major complications for obese individuals. 51 A study from Portugal by Lobato et al (2003) identified that patients with the presence of microalbuminuria at the early stage are more susceptible to developing nephropathy.…”

Section: Discussionmentioning

confidence: 99%

“…50,51 Also, the progression of diabetic nephropathy can be insidious and lead to major complications for obese individuals. 51 A study from Portugal by Lobato et al (2003) identified that patients with the presence of microalbuminuria at the early stage are more susceptible to developing nephropathy. Therefore, they concluded that the measurement of microalbuminuria could be a prognostic indicator for renal diseases.…”

Section: Discussionmentioning

confidence: 99%

The impact of microalbuminuria and insulin resistance as prognostic biomarker for nephropathy in obese persons: a systematic review

Jha,

Dhok,

Shukla

et al. 2023

F1000Res

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Background: The progression of weight gain over the normal level is accompanied by an increase in renovascular damage markers, such as microalbuminuria. Microalbuminuria could be an indication of vascular disturbances caused by obesity. The global pandemic of renal disease has something to do with the link between obesity and type-2 diabetes. Furthermore, microalbuminuria can also be a possible factor for developing insulin resistance syndrome and high blood pressure. The goal of this research is to analyze the impact that insulin resistance, as well as microalbuminuria, play in predicting the severity of nephropathy among obese individuals and also look into these markers in identifying patients with this condition. Methods: The selected studies (updated to November 2022) were evaluated using the Electronic PubMed database. Based on our selection criteria only those that included high-quality investigations on the relevance of insulin resistance and microalbuminuria as markers of nephropathy in obese people were included. We evaluated this link using odds ratios with a confidence interval of 95%. Results: Overall, 15 studies, including over 10,000 obese individuals, were evaluated for this study. The summative results revealed that microalbuminuria and insulin may be strong indicators for the advancement of nephropathy in individuals with diabetes mellitus and obese individuals. In support of this, more studies need to be carried out on obese individuals with nephropathy in the absence of diabetes to confirm the relevance of these biomarkers as a prevention measure. Conclusions: Understanding the importance of the impact microalbuminuria and resistance to insulin play as biomarkers in the health of obese individuals may be very important to prevent nephropathy progression and premature death in both diagnosed and undiagnosed situations. A limitation of this review is that it didn't focus on other anomalies related to obesity such as cardiovascular disease or diabetes.

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“…Yang et al have shown that in patients with cardiovascular disease, elevated levels of high-sensitivity CRP increase the risk of developing microalbuminuria [ 26 ]. It cannot be excluded that we would observe a similar association with longer duration of obesity.…”

Section: Discussionmentioning

confidence: 99%

Alpha-1 Acid Glycoprotein and Podocin mRNA as Novel Biomarkers for Early Glomerular Injury in Obese Children

Medyńska

Chrzanowska

Kościelska‐Kasprzak

et al. 2021

JCM

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Introduction: Obesity, which is a serious problem in children, has a negative impact on many organs, including kidneys, and obesity-related glomerulopathy (ORG) is an increasingly common cause of ESKD (end-stage kidney disease) in adults. Early-detected and -treated glomerular lesions are reversible, so it is important to find a useful marker of early damage. The study aimed to evaluate the albumin-to-creatinine ratio (ACR), urinary alpha-1-acid glycoprotein (α1-AGP), and mRNA of podocyte-specific proteins as indicators of glomerular injury and their relationship with the degree of obesity and metabolic disorders. Materials and Methods: A total of 125 obese children and 33 healthy peers were enrolled. Patients were divided into two groups, depending on SDS BMI values. ACR, α1-AGP, mRNA expression of nephrin, synaptopodin, podocin, and C2AP protein in urine sediment were measured. Results: ACR values did not differ between groups and were within the normal range. α1-AGP and mRNA expression were significantly higher in obese children compared with controls. mRNA expression of the remaining podocyte proteins was similar in both groups. No significant differences concerning all examined parameters were found depending on the degree of obesity. There was a positive significant correlation between α1-AGP and ACR. Conclusions: Increased α1-AGP before the onset of albuminuria suggests its usefulness as a biomarker of early glomerular damage in obese children. An increased podocin mRNA expression also indicates podocyte damage and may be linked to ORG development. The lack of increase in expression of other podocyte proteins suggests that podocin mRNA may be a more specific and sensitive biomarker. The degree of obesity has no impact on the tested parameters, but further studies are needed to confirm it.

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Elevated High Sensitivity C‐Reactive Protein Increases the Risk of Microalbuminuria in Subjects With Cardiovascular Disease Risk Factors

Cited by 8 publications

References 40 publications

Correlation between Serum High-Sensitivity C-Reactive Protein Level and Severity of Albuminuria Measured by Urine Albumin-to-Creatinine Ratio in Type 2 Diabetic Patients

Correlation between Serum High-Sensitivity C-Reactive Protein Level and Severity of Albuminuria Measured by Urine Albumin-to-Creatinine Ratio in Type 2 Diabetic Patients

The impact of microalbuminuria and insulin resistance as prognostic biomarker for nephropathy in obese persons: a systematic review

Alpha-1 Acid Glycoprotein and Podocin mRNA as Novel Biomarkers for Early Glomerular Injury in Obese Children

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