Elevated high-mannose N-glycans hamper endometrial decidualization

Chen, Siyi; Zhang, Aihui; Li, Na; Wu, Hongpan; Li, Yaqi; Liu, Shuai; Yan, Qiu

doi:10.1016/j.isci.2023.108170

iScience

2023

DOI: 10.1016/j.isci.2023.108170

|View full text |Cite

Elevated high-mannose N-glycans hamper endometrial decidualization

Siyi Chen,

Aihui Zhang,

Na Li

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

The Sweet Relationship between the Endometrium and Protein Glycosylation

Zhang,

Feng,

Zhang

et al. 2024

Biomolecules

View full text Add to dashboard Cite

The endometrium is an important part of women’s bodies for menstruation and pregnancy. Various proteins are widely expressed on the surface of endometrial cells, and glycosylation is an important post-translational modification of proteins. Glycosylation modification is closely related not only to endometrial receptivity but also to common diseases related to endometrial receptivity. Glycosylation can improve endometrial receptivity, promote embryo localization and trophoblast cell adhesion and invasion, and contribute to successful implantation. Two diseases related to endometrial receptivity include endometriosis and endometrial cancer. As a common benign disease in women, endometriosis is often accompanied by an increased menstrual volume, prolonged menstrual periods, progressive and aggravated dysmenorrhea, and may be accompanied by infertility. Protein glycosylation modification of the endometrial surface indicates the severity of the disease and may be an important pathogenesis of endometriosis. In cancer, glycosylation modifications on the surface of tumor cells can be a marker to distinguish the type and severity of endometrial cancer. This review highlights the role of protein glycosylation in embryo–maternal endometrial dialogue and explores its potential mechanisms in diseases related to endometrial receptivity, which could provide a new clinical approach for their diagnosis and treatment.

show abstract

The Sweet Relationship between the Endometrium and Protein Glycosylation

Zhang,

Feng,

Zhang

et al. 2024

Biomolecules

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Elevated high-mannose N-glycans hamper endometrial decidualization

Cited by 1 publication

References 51 publications

The Sweet Relationship between the Endometrium and Protein Glycosylation

The Sweet Relationship between the Endometrium and Protein Glycosylation

Contact Info

Product

Resources

About