Elevated GRHL2 Imparts Plasticity in ER-Positive Breast Cancer Cells
Christy Zheng,
Kaelyn O. Allen,
Tianrui Liu
et al.
Abstract:Estrogen receptor (ER)-positive breast cancer is characterized by late recurrences following initial treatment. The epithelial cell fate transcription factor Grainyhead-like protein 2 (GRHL2) is overexpressed in ER-positive breast cancers and is linked to poorer prognosis as compared to ER-negative breast cancers. To understand how GRHL2 contributes to progression, GRHL2 was overexpressed in ER-positive cells. We demonstrated that elevated GRHL2 imparts plasticity with stem cell- and dormancy-associated traits… Show more
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