Elevated glycohemoglobin HbA1c is associated with low back pain in nonoverweight diabetics

Real, Alexander M.; Ukogu, Chierika; Krishnamoorthy, Divya; Zubizarreta, Nicole; Cho, Samuel K.; Hecht, Andrew C.; Iatridis, James C.

doi:10.1016/j.spinee.2018.05.035

Cited by 8 publications

(8 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several recent studies have investigated the effects of the clustering of MetS components on musculoskeletal disorders [6, 8], as well as on CVD or mortality [3, 4]. In addition, the associations of LBP with individual factors of MetS have been investigated, including abdominal obesity [22], hypertension [23], dyslipidemia [17], and impaired blood glucose [24]. However, none have investigated the effect of the accumulation of MetS components on LBP.…”

Section: Discussionmentioning

confidence: 99%

“…Although several studies have investigated associations between LBP and individual components of MetS such as abdominal obesity [22], hypertension [23], impaired blood glucose [24], and lipid disturbance [17], data on the relationship between LBP and MetS itself are very scarce in the population setting. Only one community-based study has described such associations [25], indicating a significant association between LBP and MetS in women only.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Sex differences in the association of metabolic syndrome with low back pain among middle-aged Japanese adults: a large-scale cross-sectional study

et al. 2019

View full text Add to dashboard Cite

Background Although some recent studies have indicated an association between metabolic syndrome (MetS) and musculoskeletal disease, little is known about the association of MetS with low back pain (LBP). The present study aimed to investigate sex differences in the association of MetS and the clustering of MetS components with LBP among middle-aged Japanese individuals. Methods Study subjects were 45,192 adults (30,695 men, 14,497 women) aged 40–64 years who underwent annual health checkups conducted from April 2013 to March 2014. MetS was defined according to the criteria of the Examination Committee of Criteria for MetS in Japan as abdominal obesity plus at least two of dyslipidemia, high blood pressure, or high blood glucose. Information on LBP and health-related lifestyles were collected using a self-administered questionnaire. Logistic regression modeling was used to calculate the odds ratio (OR) and 95% confidence interval (CI) for LBP. Results After adjusting for age and lifestyle factors, the OR of MetS for LBP was 1.15 (95% CI 0.95–1.40) in men and 2.16 (95% CI 1.32–3.53) in women. Compared to subjects without abdominal obesity, the presence of abdominal obesity significantly increased the OR for LBP among men (abdominal obesity only: OR 1.34, 95% CI 1.02–1.76; abdominal obesity plus one component: OR 1.24, 95% CI 1.01–1.52; abdominal obesity plus two or more components: OR 1.26, 95% CI 1.02–1.55). Among women, adding other components of MetS to abdominal obesity significantly increased ORs for LBP (abdominal obesity only: OR 1.70, 95% CI 0.94–3.08; abdominal obesity plus one component: OR 1.66, 95% CI 1.06–2.60; abdominal obesity plus two or more components: OR 2.30, 95% CI 1.41–3.78). Conclusions This large-scale cross-sectional study indicated that MetS was significantly associated with LBP among women only and that a sex-difference existed in the association between the clustering of MetS components and LBP. Clustering of MetS components by sex may need to be considered for the prevention of LBP, although further prospective studies are needed to clarify the causality.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sex differences in the association of metabolic syndrome with low back pain among middle-aged Japanese adults: a large-scale cross-sectional study

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Insulin resistance was assessed using the HOMA-IR, which was calculated from fasting levels of insulin and glucose, using the formula [fasting serum insulin (μU/mL) × fasting plasma glucose (mmol/L)/22.5], analyzed as a continuous variable and further categorized based on the cutoff point of 2.5 [40]. Individuals were identified as having diabetes if their HbA 1c was ≥6.5% [41]. Chronic inflammation was measured using CRP by latex-enhanced nephelometry and analyzed as a dichotomous variable based on the cutoff point of one suggesting clinically raised CRP [42].…”

Section: Methodsmentioning

confidence: 99%

Anti-Müllerian Hormone Levels and Cardiometabolic Disturbances by Weight Status Among Men in the 1999 to 2004 National Health and Nutrition Examination Survey

Beydoun

Hossain

Beydoun

et al. 2019

Journal of the Endocrine Society

View full text Add to dashboard Cite

Context Serum anti-Müllerian hormone level (AMH) and body mass index may be jointly associated with cardiometabolic risk. Objectives Examine the contribution of AMH to cardiometabolic disturbances by weight status among US adult men. Design Cross-sectional analysis using data from the 1999 to 2004 waves of the National Health and Nutrition Examination Survey. Setting Multistage probability sampling of the noninstitutionalized US population. Participants US men aged ≥18 years. Final analytic sample sizes ranged from 517 to 1063 participants. Main Outcome and Exposure Measures Cardiometabolic disturbances (metabolic syndrome and its components, insulin resistance, diabetes, and chronic inflammation) and AMH were obtained from trained staff and nurses in a mobile examination center or during in-home visits. Results AMH was directly associated with insulin resistance among obese men [OR 1.08 (95% CI 1.00, 1.15); P = 0.046; N = 146], whereas AMH was inversely associated with waist circumference (WC) among obese men [OR 0.95 (95% CI 0.91, 0.99); P = 0.049; N = 146]. An inverse relationship was also observed between categorical AMH and diabetes status [medium vs low AMH; OR 0.19 (95% CI 0.043, 0.84); P = 0.030; N = 145] among obese men, with a strong inverse relationship also detected among overweight men [high vs low AMH; OR 0.011 (95% CI 0.0004, 0.27); P = 0.007; N = 193]. An inverse relationship between continuous AMH and diabetes [OR 0.75 (95% CI: 0.59, 0.93); P = 0.011; N = 193] was also detected among overweight men. Conclusions AMH was associated with specific cardiometabolic risk factors, including WC, diabetes status, and insulin resistance, in overweight and obese US men.

show abstract

“…An association between diabetes and LBP has been indicated in some population studies 3 4. Other studies have suggested a relationship between increased blood glucose levels and LBP 5 6. It has also been suggested that lumbar spinal stenosis may be associated with diabetes mellitus 7…”

Section: Introductionmentioning

confidence: 98%

Does diabetes influence the probability of experiencing chronic low back pain? A population-based cohort study: the Nord-Trøndelag Health Study

Heuch

Hagen

et al. 2019

BMJ Open

View full text Add to dashboard Cite

ObjectiveLow back pain (LBP) is a major problem in modern society and it is important to study possible risk factors for this disorder. People with diabetes are often affected by LBP, but whether diabetes represents a risk factor for LBP has not been studied in detail. The aim of this study was to explore the association between diabetes and subsequent risk of chronic LBP.DesignAn 11-year follow-up study.SettingThe Nord-Trøndelag Health Study (HUNT2; 1995–1997) and HUNT3 (2006–2008) surveys of Nord-Trøndelag County in Norway.Main outcome measureChronic LBP, defined as LBP persisting at least 3 months continuously during the last year.ParticipantsA total of 18 972 persons without chronic LBP at baseline in HUNT2, and 6802 persons who reported chronic LBP at baseline in HUNT2.MethodsAssociations between diabetes and risk of chronic LBP among individuals aged 30–69 years were examined by generalised linear modelling.ResultsMen without chronic LBP at baseline showed a significant association between diabetes and risk of chronic LBP (relative risk (RR) 1.43, 95% CI 1.04 to 1.96, p=0.043). In women, no association was found (RR 1.01, 95% CI 0.69 to 1.48, p=0.98). No association could be established between diabetes and recurrence or persistence of chronic LBP after 11 years in either sex.ConclusionsMen with a diagnosis of diabetes may have a higher risk of subsequently experiencing chronic LBP.

show abstract

Elevated glycohemoglobin HbA1c is associated with low back pain in nonoverweight diabetics

Cited by 8 publications

References 33 publications

Sex differences in the association of metabolic syndrome with low back pain among middle-aged Japanese adults: a large-scale cross-sectional study

Sex differences in the association of metabolic syndrome with low back pain among middle-aged Japanese adults: a large-scale cross-sectional study

Anti-Müllerian Hormone Levels and Cardiometabolic Disturbances by Weight Status Among Men in the 1999 to 2004 National Health and Nutrition Examination Survey

Does diabetes influence the probability of experiencing chronic low back pain? A population-based cohort study: the Nord-Trøndelag Health Study

Contact Info

Product

Resources

About