Elevated Galectin-10 Expression of IL-22-Producing T Cells in Patients with Atopic Dermatitis

Noh, Seongmin; Jin, Songqing; Park, Chang Ook; Lee, Yun Sun; Lee, Nara; Lee, Jungsoo; Shin, Jung U; Kim, Seo Hyeong; Yun, Ki Na; Kim, Jin Young; Lee, Kwang Hoon

doi:10.1038/jid.2015.369

Cited by 22 publications

(16 citation statements)

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“…Previous data of IL‐22 and Th22 levels in Asian patients with AD come mainly from Japan and Korea . China, the largest Asian country, is a multinational country composed of 56 ethnic groups of which the Han Chinese account for 91·6%.…”

Section: Discussionmentioning

confidence: 99%

“…Previous data of IL-22 and Th22 levels in Asian patients with AD come mainly from Japan and Korea. 4,14,16,28 China, the largest Asian country, is a multinational country composed of 56 ethnic groups of which the Han Chinese account for 91Á6%. For the first time, our findings show that levels of circulating Th22 cells and serum concentrations of IL-22 are increased in Han Chinese patients with AD.…”

Section: Discussionmentioning

confidence: 99%

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T helper 22 cells from Han Chinese patients with atopic dermatitis exhibit high expression of inducible T‐cell costimulator

et al. 2019

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Summary Background Atopic dermatitis (AD) is a heterogeneous disease, characterized by excess T helper (Th) 22 activation in Asian AD. Inducible T‐cell costimulator (ICOS) is crucial for T‐cell activation and differentiation. However, the role of ICOS in AD and its effect on Th22 cells remain unclear. Objectives To gain a better understanding of the role of ICOS and ICOS ligand (ICOSL) in the pathogenesis of Asian AD and its underlying mechanisms. Methods We quantified ICOS and ICOSL expression in Han Chinese patients with AD and healthy controls (HC). Then, we assessed the proliferation and the production of the Th22 chemokines CCR4 and CCR10 by ICOSL‐stimulated AD peripheral blood mononuclear cells (PBMCs) as well as their effects on keratinocyte filaggrin production. Finally, we explored the link between ICOS‐expressing Th22 cells and disease activity and IgE levels in our patients with AD. Results Our patients with AD showed higher levels of ICOS‐expressing Th22 cells as well as ICOSL‐expressing CD19+ B cells and CD14+ monocytes compared with HC. ICOSL increased the proliferation and expression of CCR4 and CCR10, and of interleukin (IL)‐22 in AD PBMCs. ICOSL treatment also significantly increased the downregulation of filaggrin expression by keratinocytes cocultured with PBMCs from patients with AD. Finally, blood levels of ICOS+ Th22 cells and ICOSL+ B cells in this AD cohort were correlated with disease activity as assessed by the SCORing Atopic Dermatitis index and with total IgE levels. In Han Chinese patients with AD, circulating Th22 cells, serum levels of IL‐22 and IL‐22+ cells in lesional skin were all markedly increased. Conclusions Our findings demonstrate that ICOS/ICOSL expression and effects are linked to Th22 skewing and the pathogenesis of Han Chinese AD, which suggests ICOSL and ICOS as well as Th22 cells and IL‐22 as new and promising therapeutic targets. What's already known about this topic? In Asian patients, atopic dermatitis (AD) is characterized by excess T helper (Th) 22 activation. Inducible T‐cell costimulator (ICOS) is crucial for T‐cell activation and differentiation. What does this study add? This study demonstrates that circulating Th22 cells, serum levels of interleukin (IL)‐22 and IL‐22+ cells are all markedly increased in lesional skin in Han Chinese patients with AD. In Han Chinese patients with AD, ICOS and ICOS ligand (ICOSL) drive Th22 skewing and increase filaggrin downregulation, and ICOS+ Th22 cells and ICOSL+ B cells are linked to disease activity. What is the translational message? ICOS+ Th22 cells and ICOSL+ B cells are potential clinical biomarkers of disease activity in Han Chinese patients with AD. ICOS‐ and ICOSL‐targeted treatment approaches may benefit Han Chinese patients with AD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

T helper 22 cells from Han Chinese patients with atopic dermatitis exhibit high expression of inducible T‐cell costimulator

et al. 2019

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“…In T-cells, Gal-10 is also expressed, and has been identified as a marker for anergy and suppressive function of CD25+ Treg cells [ 87 ]. In patients with atopic dermatitis, the expression level of Gal-10 in circulating CD3+ T cells and IL-22-production in CD4+ T cells are elevated [ 88 ]. Eosinophils can even connect with the outer membrane of T cells with synapses that are partially constituted by Gal-10 [ 89 ].…”

Section: Distribution Of Gal-10 In Variable Lymphocytesmentioning

confidence: 99%

A Brief History of Charcot-Leyden Crystal Protein/Galectin-10 Research

2018

Molecules

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Eosinophils are present in tissues, such as the respiratory tract, spleen, lymph nodes and blood vessels. The significant presence of eosinophils in these tissues are associated with various diseases, including asthma, allergies, acute myeloid leukemia, etc. Charcot-Leyden crystal protein/galectin-10 is overexpressed in eosinophils and has also been identified in basophils and macrophages. In human body, this protein could spontaneously form Charcot-Leyden crystal in lymphocytes or in the lysates of lymphocytes. At present, the role of Charcot-Leyden crystal protein/galectin-10 in lymphocytes is not fully understood. This review summarizes research progress on Charcot-Leyden crystal protein/galectin-10, with emphasis on its history, cellular distributions, relations to diseases, structures and ligand binding specificity.

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“…Since its beginning, the specialty clinic for allergen-specific immunotherapy has registered over 800 patients and the successful treatment outcomes were published in 2013 19 . Kwang Hoon Lee and his research team have carried out basic and clinical research on abnormalities in atopic dermatitis, connections between stress and immune regulation, and new targets of atopic dermatitis, and his work has been published in high impact journals [20][21][22] .…”

Section: Contact Dermatitis and Atopic Dermatitismentioning

confidence: 99%

Centennial History of Yonsei University Dermatology in Korea: 1917 to 2017

Kim

Lee

et al. 2018

Ann Dermatol

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Yonsei Dermatology celebrated its centennial in 2017, marking 100 years since Kung Sun Oh established the first Department of Dermatology and Urology in Korea in 1917. Following the footsteps of Kung Sun Oh, a pioneer of Korean dermatology, its members united and worked to provide the best medical service and achieve academic milestones in dermatology. Over the past hundred years, Yonsei Dermatology has played a pivotal role in the advancement of medical science and academia in Korea. The main activities of the department include medical care, education, and dermatologic research. Its research activities have encompassed a wide spectrum of dermatologic manifestations from skin immunology and pathology to introduction of newly developed treatment technologies. As Kung Sun Oh was the first Korean professor of dermatology at Severance Medical School and a passionate educator, we continue to serve his will by nurturing medical students and dermatology specialists to serve as global medical leaders. The Kung Sun Oh Memorial Lecture, first hosted in 1977, was the beginning of mutual international academic exchange in the field of dermatology in Korea. The memorial lecture has played a major role in advancing the academic status of Korean dermatological science by inviting distinguished dermatologists from around the world as guest lecturers. Yonsei Dermatology has played a key role in the history of modern medicine and dermatology in Korea over the last 100 years and continues to make an impact. (Ann Dermatol 30(5) 513∼521, 2018

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Elevated Galectin-10 Expression of IL-22-Producing T Cells in Patients with Atopic Dermatitis

Cited by 22 publications

References 14 publications

T helper 22 cells from Han Chinese patients with atopic dermatitis exhibit high expression of inducible T‐cell costimulator

T helper 22 cells from Han Chinese patients with atopic dermatitis exhibit high expression of inducible T‐cell costimulator

A Brief History of Charcot-Leyden Crystal Protein/Galectin-10 Research

Centennial History of Yonsei University Dermatology in Korea: 1917 to 2017

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