Elevated fibrous sheath interacting protein 1 levels are associated with poor prognosis in non-small cell lung cancer patients

Abstract

In this study, we examined the expression and prognostic value of fibrous sheath interacting protein 1 (FSIP1) in 202 non-small cell lung cancer (NSCLC) patients who underwent lung cancer resection at Shengjing Hospital of China Medical University. FSIP1 mRNA and protein expression were measured in NSCLC tissues and non-tumor adjacent tissues (NATs), and Harrell's concordance index (c-index) was used to evaluate the ability of FSIP1 to predict prognosis. FSIP1 mRNA and protein expression was higher in NSCLC tissues than in NATs. Survival analysis revealed the 5-year overall survival rate to be 35.4% in the FSIP1-positive group and 56.3% in the FSIP1-negative group, and FSIP1-positive status was an independent prognostic factor for poor overall survival. The c-index value of FSIP1 for overall survival was greater than that of Ki67, and the addition of FSIP1 status increased the c-index value of the TNM staging system. These results suggest that evaluating FSIP1 status in addition to TNM stage during routine pathological examinations could improve prognostic predictions in NSCLC patients.

Novel DNA methylation sites associated with cigarette smoking among African Americans

“…Fibrous Sheath Interacting Protein 1 (FSIP1) is also a protein coding gene, and increased mRNA expression of this gene has been associated with breast tumors [21]. FSIP1 has also been associated with poorer prognosis in lung cancers [22]. ALPP (Alkaline Phosphatase, Placental) is primarily expressed in endometrial and placental tissue and has also been associated with ovarian cancers [23].…”

Overexpression of HPIP as a biomarker for metastasis and prognosis prediction in endometrial cancer patients

“…[4][5][6][7][8][9][10][11][12][13][14][15] However, by reviewing the literature, we have not found a report on the expression of HPIP in endometrial cancer. According to the currently reported studies, HPIP exhibited an excessive expression status in numerous cancer tissues, while HPIP expression is involved in various aspects of cancer progression and predicts poor prognosis in cancer patients.…”

“…According to the currently reported studies, HPIP exhibited an excessive expression status in numerous cancer tissues, while HPIP expression is involved in various aspects of cancer progression and predicts poor prognosis in cancer patients. [4][5][6][7][8][9][10][11][12][13][14][15] However, by reviewing the literature, we have not found a report on the expression of HPIP in endometrial cancer.…”

FSIP1 regulates autophagy in breast cancer

“…Fibrous sheath interacting protein 1 (FSIP1) is a cancer/testis antigen (16) expressed in the majority of breast cancers, bladder cancers, and nonsmall cell lung cancer (17)(18)(19). Our previous findings and those of others show that high FSIP1 expression is associated with increased invasiveness and poor prognosis in breast cancer (19,20).…”