Abstract:Insufficient sleep induces insulin resistance and is associated with an increased risk for developing obesity and cardiometabolic diseases, implicating sleep loss as a metabolic stressor. Fibroblast growth factor 21 (FGF21) is a hepatokine secreted in response to stress and is elevated in human obesity and diabetes. FGF21 expression can be induced by free fatty acid (FFA) activation of peroxisome proliferator‐activator receptor alpha. We previously reported that insufficient sleep results in elevated FFA; howe… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.