Elevated Expression of Transforming Acidic Coiled-Coil Containing Protein 3 (TACC3) Is Associated With a Poor Prognosis in Osteosarcoma

Matsuda, Kazunobu; Miyoshi, Hiroaki; Hiraoka, Koji; Hamada, Tetsuya; Nakashima, Kenichiro; Shiba, Naoto; Ohshima, Koichi

doi:10.1097/corr.0000000000000379

Cited by 17 publications

(26 citation statements)

References 34 publications

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“…TACC3 over-expression is associated with Ki-67, which contributes to the aggressiveness of ATLL through the cell's proliferative potential. Similar to our previous report in sarcomas, 12,13 there was a strong correlation between TACC3 over-expression and Ki-67 index in our study (P = .01, data not shown). High TACC3 expression and tumor stage are also associated with solid cancers, 12,13 suggesting that TACC3 expression is related to tumor aggressiveness.…”

Section: Discussionsupporting

confidence: 92%

“…Similar to our previous report in sarcomas, 12,13 there was a strong correlation between TACC3 over-expression and Ki-67 index in our study (P = .01, data not shown). High TACC3 expression and tumor stage are also associated with solid cancers, 12,13 suggesting that TACC3 expression is related to tumor aggressiveness. In ATLL, we also compared nPD-1, miPD-1, CCR4, and TACC3 expression, which we previously reported as aggressive prognostic markers, 15 other than Ki-67, but there was no correlation between them and TACC3.…”

Section: Discussionsupporting

confidence: 92%

“…11 Additionally, our group previously reported that the over-expression of TACC3 correlates with shorter overall survival and disease-free survival in soft tissue sarcoma and osteosarcoma. 12,13 Reports have also shown that TACC3 expression may affect clinicopathological features.…”

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confidence: 99%

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TACC3 expression as a prognostic factor in aggressive types of adult T‐cell leukemia/lymphoma patients

Moritsubo

Miyoshi

Matsuda

et al. 2020

Int J Lab Hematology

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Adult T-cell leukemia/lymphoma (ATLL) is a malignant peripheral T-cell neoplasm associated with human T-cell leukemia virus type-1 (HTLV-1). Approximately 10 to 20 million people are infected with HTLV-1 worldwide, with at least 1 million of these infections occurring in Japan. Approximately 1000 HTLV-1 carriers develop ATLL each year after an incubation period of several decades. 1,2 Based on clinical and laboratory findings, ATLL is classified into four clinical subtypes: acute, lymphoma, chronic, and smoldering. The acute and lymphoma subtypes are regarded as aggressive ATLLs; therefore, patients diagnosed with these subtypes undergo several intensive rounds of chemotherapy and stem cell transplantation. 3,4 Diagnosis at an older age is identified as a poor prognostic factor in

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

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TACC3 expression as a prognostic factor in aggressive types of adult T‐cell leukemia/lymphoma patients

Moritsubo

Miyoshi

Matsuda

et al. 2020

Int J Lab Hematology

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“…Osteosarcoma (OS) is the most common primary malignant tumour of the bone, with an incidence rate of 1-3% worldwide [1]. OS is particularly common in children and adolescents, followed by individuals over 50 years of age [2].…”

Section: Introductionmentioning

confidence: 99%

ROCK2 promotes osteosarcoma growth and glycolysis by up-regulating HKII via phospho- PI3K/AKT signalling

Deng

et al. 2020

Preprint

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Background Osteosarcoma (OS) is a malignant bone tumour that exhibits a high mortality. While tumours thrive in a state of malnutrition, the mechanism by which OS cells adapt to metabolic stress through metabolic reprogramming remains unclear. Methods We analysed the expression of ROCK2 in osteosarcoma patients by RT-qPCR and Western blot. Cell proliferation, and colony formation were analysed using CCK8, EdU assays and colony formation assays. The level of Cell glycolysis was detected by glucose-6 phosphate, glucose consumption, lactate production and ATP levels. Results Herein, our study showed that ROCK2 expression in OS was higher than in adjacent tissues. Functional assays have demonstrated that ROCK2 contributes to the growth of OS cells by inducing aerobic glycolysis. The current study revealed that ROCK2 knockdown decreased the levels of mitochondrial hexokinase II (HKII). And also indicated that ROCK2 served as a key enzyme in glycolysis and that it served an important role in tumour growth and metastasis. A significant positive correlation was identified between the mRNA and protein expressions of ROCK2 and HKII, further demonstrating that ROCK2-induced glycolysis and proliferation was dependent on HKII in OS cells. Mechanistically, ROCK2 promotes HKII expression by activating the phospho-PI3K/AKT signalling pathway. Conclusions Taken together, the results of the current study linked the two drivers of OS growth and aerobic glycolysis, and identified a new mechanism of ROCK2 control in OS.

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“…Osteosarcoma (OS) is the most common primary malignant tumour of the bone, with an incidence rate of 1-3% worldwide [1]. And it's particularly common in children and adolescents, followed by individuals over 50 years of age [2].…”

Section: Introductionmentioning

confidence: 99%

ROCK2 promotes osteosarcoma growth and glycolysis by up-regulating HKII via phospho-PI3K/AKT signalling

Deng

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Osteosarcoma (OS) is a malignant bone tumour that exhibits a high mortality. While tumours thrive in a state of malnutrition, the mechanism by which OS cells adapt to metabolic stress through metabolic reprogramming remains unclear. Methods: We analysed the expression of ROCK2 in osteosarcoma tissues by RT-qPCR and Western blot. Cell proliferation were analysed using CCK8, EdU and colony formation assays. The level of Cell glycolysis was detected by glucose-6 phosphate, glucose consumption, lactate production and ATP levels.Results: Herein, our study showed that ROCK2 expression in OS tissues was higher than in adjacent tissues. Functional assays have demonstrated that ROCK2 contributes to the growth of OS cells by inducing aerobic glycolysis. The current study revealed that ROCK2 knockdown decreased the levels of mitochondrial hexokinase II (HKII). And also indicated that ROCK2 served as a key enzyme in glycolysis and that it served an important role in tumour growth. A significant positive correlation was identified between the mRNA and protein expressions of ROCK2 and HKII, further demonstrating that ROCK2-induced glycolysis and proliferation was dependent on HKII expression in OS cells. Mechanistically, ROCK2 promotes HKII expression by activating the phospho-PI3K/AKT signalling pathway. Conclusions: Taken together, the results of the current study linked the two drivers of OS growth and aerobic glycolysis, and identified a new mechanism of ROCK2 control in OS.

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Elevated Expression of Transforming Acidic Coiled-Coil Containing Protein 3 (TACC3) Is Associated With a Poor Prognosis in Osteosarcoma

Abstract: Level III, therapeutic study.

Cited by 17 publications

References 34 publications

TACC3 expression as a prognostic factor in aggressive types of adult T‐cell leukemia/lymphoma patients

TACC3 expression as a prognostic factor in aggressive types of adult T‐cell leukemia/lymphoma patients

ROCK2 promotes osteosarcoma growth and glycolysis by up-regulating HKII via phospho- PI3K/AKT signalling

ROCK2 promotes osteosarcoma growth and glycolysis by up-regulating HKII via phospho-PI3K/AKT signalling

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