Elevated expression of HMGB1 is prognostic of poor survival in patients with relapsed/refractory T/NK-CL

Wang, Caiqin; Wang, Yu; Jie, Cao; Sun, Xiao‐Feng; He, Xiaohua; Sun, Peng; Gao, Tianxiao; Huang, Jiajia; Li, Zhiming

doi:10.1007/s00277-021-04473-4

Cited by 2 publications

(2 citation statements)

References 26 publications

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“…Since old aged ATA B tumor showed DAMP/HMGB1 + and AID + , it is possible that EMP increased with changed to CD24 low with CD44 ++ . Ki67 is increased from HMGB1 [ 153 ], and TC – ZAP70 + showed both highest Ki67 and HMGB1, then lowest CD24 in TC – ZAP70 + than TC – ZAP70 – (Fig. 4 A3).…”

Section: Resultsmentioning

confidence: 99%

B-1 derived anti-Thy-1 B cells in old aged mice develop lymphoma/leukemia with high expression of CD11b and Hamp2 that different from TCL1 transgenic mice

Hayakawa,

Zhou,

Shinton

2024

Immun Ageing

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Human old aged unmutated chronic lymphocytic leukemia U-CLL are the TCL1+ZAP70+CD5+ B cells. Since CD5 makes the BCR signaling tolerance, ZAP70 increased in U-CLL not only TCL1+ alone. In mice, TCL1 (TCL1A) is the negative from neonate to old aged, as TC–. VH8-12/Vk21-5 is the anti-thymocyte/Thy-1 autoreactive ATA B cell. When ATA μκTg generation in mice, ATA B cells are the neonate generated CD5+ B cells in B-1, and in the middle age, CD5+ can be down or continuously CD5+, then, old aged CLL/lymphoma generation with increased CD11b in TC–ZAP70–CD5– or TC–ZAP70+CD5+. In this old aged TC–ATA B microarray analysis showed most similar to human CLL and U-CLL, and TC–ZAP70+CD5+ showed certain higher present as U-CLL. Original neonate ATA B cells showed with several genes down or further increase in old aged tumor, and old aged T-bet+CD11c+, CTNNB1hi, HMGBhi, CXCR4hi, DPP4hi and decreased miR181b. These old aged increased genes and down miR181b are similar to human CLL. Also, in old age ATA B cell tumor, high CD38++CD44++, increased Ki67+ AID+, and decreased CD180– miR15Olow are similar to U-CLL. In this old aged ATA B, increased TLR7,9 and Wnt10b. TC+Tg generated with ATAμκTg mice occurred middle age tumor as TC+ZAP70–CD5+ or TC+ZAP70+CD5+, with high NF-kB1, TLR4,6 and Wnt5b,6 without increased CD11b. Since neonatal state to age with TC+Tg continuously, middle age CLL/lymphoma generation is not similar to old aged generated, however, some increased in TC+ZAP70+ are similar to the old age TC– ATA B tumor. Then, TC– ATA B old age tumor showed some difference to human CLL. ATA B cells showed CD11b+CD22++, CD24 down, and hepcidin Hamp2++ with iron down. This mouse V8-12 similar to human V2-5, and V2-5 showed several cancers with macrophages/neutrophils generated hepcidin+ ironlow or some showed hepcidin– iron+ with tumor, and mouse V8-12 with different Vk19-17 generate MZ B cells strongly increased macrophage++ in old aged and generated intestine/colon tumor. Conclusion, neonate generated TC–ATA B1 cells in old aged tumor generation are CD11b+ in the leukemia CLL together with lymphoma cancer with hepcidin-related Hamp2++ in B-1 cell generation to control iron.

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Section: Resultsmentioning

confidence: 99%

B-1 derived anti-Thy-1 B cells in old aged mice develop lymphoma/leukemia with high expression of CD11b and Hamp2 that different from TCL1 transgenic mice

Hayakawa,

Zhou,

Shinton

2024

Immun Ageing

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“…High Ki-67 expression is considered to be a poor prognostic factor in many types of lymphoma, such as mantle cell lymphoma, diffuse large B-cell lymphoma, follicular lymphoma, and peripheral T-cell lymphomas. [19][20][21][22][23][24] However, its prognostic value for HSTCL remains unclear. Among the 5 Chinese cases, the survival time of Patient 3 with a high expression of Ki-67 (80%) was only 1.3 months, which was clearly shorter than the survival time of the other 4 patients (31.6 months, 45.3 months, 12.5 months, 13.3 months, respectively).…”

Section: Discussionmentioning

confidence: 99%

Survival Analysis of Hepatosplenic T Cell Lymphoma: A Population-Based Study Using SEER

Li¹,

Chen²,

Zuo³

et al. 2021

IJGM

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Elevated expression of HMGB1 is prognostic of poor survival in patients with relapsed/refractory T/NK-CL

Cited by 2 publications

References 26 publications

B-1 derived anti-Thy-1 B cells in old aged mice develop lymphoma/leukemia with high expression of CD11b and Hamp2 that different from TCL1 transgenic mice

B-1 derived anti-Thy-1 B cells in old aged mice develop lymphoma/leukemia with high expression of CD11b and Hamp2 that different from TCL1 transgenic mice

Survival Analysis of Hepatosplenic T Cell Lymphoma: A Population-Based Study Using SEER

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