Elevated expression levels of testis-specific genes<i>TEX101</i>and<i>SPATA19</i>in basal cell carcinoma and their correlation with clinical and pathological features

Ghafouri‐Fard, Soudeh; Abbasi, Ata; Moslehi, Homayoun; Faramarzi, Negar; Vakili, Sanaz; Mobasheri, Maryam Beigom; Modarressi, Mohammad Hossein

doi:10.1111/j.1365-2133.2009.09568.x

Cited by 48 publications

(39 citation statements)

References 30 publications

(26 reference statements)

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“…In addition, TSGA10 expression has been demonstrated in embryonic stem cell, in actively dividing cells, in fetal differentiating tissues and also in various primary tumors, (16) therefore it could be classified as CT antigen. Previously, our studies showed expression of TEX101, SPATA19 and LEMD1 in basal cell carcinoma (17) and prostate cancer (18, 19). …”

Section: Discussionmentioning

confidence: 70%

Expression of Testis Specific Genes TSGA10, TEX101 and ODF3 in Breast Cancer

Dianatpour¹,

Mehdipour²,

Nayernia³

et al. 2012

Iran Red Crescent Med J

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BackgroundBreast cancer is the most common malignancy in women around the world so finding new biomarkers for early detection and also study on molecular aspects of breast cancer is valuable. Cancer testis genes are a group of genes expressed solely in testis and in a range of human malignancies.ObjectivesIn this study we determined the expression of cancer testis genes Tsga10, TEX101 and ODF3 in patients with breast cancer.Materials and MethodsFifty patients with breast cancer were enrolled in this study. Breast cancer cell lines MCF-7 and MDA-MB-231 were also used to determine the expression of testis cancer genes. For both patients and cell lines, cancer testis genes of TSGA10, TEX101 and ODF3 were determined by RT-PCR. The presence of auto antibody against these genes in patients’ serums was carried on by ELISA method.ResultsSeventy percent of patients showed TSGA10 expression but none of them showed expression of TEX101 and ODF3. Fourteen percent of patients were positive for anti TSGA10 but all patients were negative for anti TEX101 and anti ODF3. Both of breast cancer cell lines exhibited very strong expression of TSGA10.ConclusionsBecause of the important roles of Tsga10 in cell proliferation, we concluded that this gene may have a role in proliferation and survival of breast cancer cells and could be used for diagnosis and immunotherapy of breast cancer.

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Section: Discussionmentioning

confidence: 70%

Expression of Testis Specific Genes TSGA10, TEX101 and ODF3 in Breast Cancer

Dianatpour¹,

Mehdipour²,

Nayernia³

et al. 2012

Iran Red Crescent Med J

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“…2,3) Many genes which were crucial for spermatogenesis and male fertility are often exclusively expressed in male germ cells. Some testis-specific genes have been screened including FAM46D, 4) Adam31, 5) PDHA2, 6) TEX101 and SPATA19, 7) etc. which have been proven to play critical roles in the process of spermatogenesis and steroidogenesis.…”

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confidence: 99%

Comparative and Functional Analysis of Testis-Specific Genes

Liu¹,

Jin²,

Li³

et al. 2011

Biological & Pharmaceutical Bulletin

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The testis is the special male gonad responsible for spermatogenesis and steroidogenesis with complex gene expressions. Characterizing and comparing the testis-specific genes in different species can reveal key genes related to testis specifical functions and provide supplementary information for study of human testis function. We screened testis-specific genes from Unigene libraries, total 317, 449 and 147 testis-specific genes were identified for human, mouse and rat, respectively. Ten from thirteen selected human testis-specific genes were validated exclusively expressed in the testis by reverse transcription polymerase chain reaction (RT-PCR). Systematic bioinformatics analysis showed that specific genes were mainly related to spermatogenesis and testis development process with significant Glycolysis and Pyruvate metabolism. Enrichment functions were discussed.Key words testis; specific; digital differential display Biol. Pharm. Bull. 34(1) 28-35 (2011) © 2011 Pharmaceutical Society of Japan * To whom correspondence should be addressed. e-mail: zxsys008@126.com Colon 7 29584 1 5219 3 5458 Heart 4 19926 8 67542 4 31600 Kidney 6 49568 10 54164 4 24601 Liver 11 72628 6 25033 3 59093 Lung 7 46559 7 40355 2 8065 Muscle 2 6424 2 3031 1 2429 Ovary 4 10862 2 6847 1 4443 Pancreas 1 4308 6 22020 1 16173 Placenta 12 71806 7 21182 2 8475 Prostate 5 63083 0 0 1 9076 Spleen 2 36689 3 46301 1 3629 Stomach 11 36759 4 18360 0 0 Thymus 4 72916 8 93976 0 0 Uterus 5 58541 0 0 0 0 Total 96 783531 74 454582 30 198862 Libraries from 18 organs against testis libraries were used in the digital differential display (DDD) program.

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“…Expression has been detected in the multiple myeloma cell lines THIEL and RPMI8226, in the testis and in two of four primary multiple myeloma tumour samples (Sahota et al, 2006). Not found in 78 basal cell carcinoma by real-time PCR (Ghafouri-Fard et al, 2010).…”

Section: Expressionmentioning

confidence: 99%