Elevated exhaled nitric oxide is a clinical indicator of future uncontrolled asthma in asthmatic patients on inhaled corticosteroids

Advances in pediatric asthma in 2011: Moving forward

“…d Exhaled nitric oxide measurement appears to be clinically useful in identifying persistent atopic, nonsmoking asthmatic patients taking ICSs at risk for future uncontrolled asthma. 95 …”

“…Zeiger et al 95 reported that FENO appears clinically useful in identifying persistent atopic, nonsmoking asthmatic patients taking ICSs at risk for future uncontrolled asthma. However, studies are still needed to determine whether such FENO information will improve future asthma care and outcomes.…”

An update on paediatric asthma

“…In a cross-sectional study, ZEIGER and co-workers [85,86] found that FeNO was a complement to symptom evaluation in that higher FeNO was associated with an increased use of SABA and the need for oral corticosteroids. Nevertheless, the clinical situation in which FeNO provides the most useful information is currently under debate [73] and the relationship between FeNO and asthma severity is unclear [76].…”

Successful Fractional Exhaled Nitric Oxide Measurements with NIOX VERO using 6- and 10-s Exhalation Modes in Children with Asthma Aged 4–10 Years: A Randomized Study

“…It is a direct marker of T-helper type 2 (Th2)-driven inflammation in the airways and can assist in the diagnosis of asthma [1], help identify patients who will respond to inhaled corticosteroids (ICS) [2], and predict risk of asthma worsening [3]. When used to regularly monitor patients, FeNO has been shown to reduce exacerbations of both in adults [4,5] and in pediatric patients [6,7].…”