Elevated Endothelial Microparticles Following Consecutive Meals Are Associated With Vascular Endothelial Dysfunction in Type 2 Diabetes

Tushuizen, Maarten E.; Nieuwland, Rienk; Rustemeijer, Cees; Hensgens, Bert E.; Sturk, Augueste; Heine, Robert J.; Diamant, Michaëla

doi:10.2337/dc06-1473

Cited by 55 publications

(39 citation statements)

References 16 publications

(25 reference statements)

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“…Two consecutive fat-rich mixed meals to healthy young males [75] or two consecutive mixed meals to T2DM patients [76] yield similar results in which impaired endothelium-dependent vasodilatation is associated with elevated levels of circulating platelet-derived MVs and endothelial-derived MVs. Increased level of CD31 + /annexin V + MVs is positively correlated with the impairment of coronary endothelial function in patients with coronary artery disease (CAD) [62] .…”

Section: Mvs and Endothelial Dysfunctionsupporting

confidence: 56%

Microvesicles and diabetic complications — novel mediators, potential biomarkers and therapeutic targets

2014

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Section: Mvs and Endothelial Dysfunctionsupporting

confidence: 56%

Microvesicles and diabetic complications — novel mediators, potential biomarkers and therapeutic targets

2014

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“…Impaired flowmediated dilation has been associated with the presence of EMPs in various clinical conditions. [85][86][87] However, the level of LMPs was not measured in these studies.…”

Section: Leukocyte-derived Microparticles and Vascular Functionmentioning

confidence: 84%

“…CD144ϩ EMPs circulate in patients with uncomplicated type 2 diabetes and are associated with postprandial metabolic derangements and impaired flow-mediated dilation. 87 CD144ϩ/annexin Vϩ EMPs are higher in patients than in control subjects and rise after consumption of meals. In healthy males, after 2 consecutive high-fat meals, mild elevations in plasma glucose and triacylglycerol were paralleled by impaired flow-mediated dilation, increased markers of oxidative stress and total circulating MPs.…”

Section: Diabetes Mellitus and Hyperlipidemiamentioning

confidence: 99%

Leukocyte-Derived Microparticles in Vascular Homeostasis

Angelillo‐Scherrer

2012

Circulation Research

183

143

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“…As it has been demonstrated that statins reduce postprandial lipid excursions in several patients groups, including MetS (Hajer et al, 2009), we excluded subjects using statins or other lipid-lowering drugs. Participants were instructed to omit their medication during the examination and to refrain from heavy physical activities during the previous 24 h. After an overnight fast, participants received three consecutive, isocaloric (900 kcal) mixed meals (75-g carbohydrates, 50-g fat and 35-g protein) at time points t ¼ 0 h (breakfast), 4 h (lunch) and 8 h (dinner) and were studied during a 16-h period (Tushuizen et al, 2007). Venous blood collections were performed before and 4 h following every single meal (t ¼ 0, 4, 8, 12 and 16 h) for measurements of plasma lipids, glucose, insulin and for measurement of the physicochemical properties of HDL and LDL.…”

Section: Methodsmentioning

confidence: 99%

Effect of three consecutive meals on the physicochemical properties of HDL and LDL in individuals with the metabolic syndrome and patients with type 2 diabetes

et al. 2011

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Background/Objectives: Postprandial hyperlipidemia, which is exaggerated and prolonged in insulin-resistant individuals, has been associated with cardiovascular disease. The objective of this study was to investigate whether and how the composition, size and function of high-density lipoprotein (HDL) and low-density lipoprotein (LDL) particles are affected in the postprandial state among males with the metabolic syndrome (MetS) or type 2 diabetes (T2DM), compared with controls. Subjects/Methods: A total of 14 males with T2DM, 14 with the MetS and 14 age-matched controls were given three standardized high-fat mixed meals (900 kcal; 50-g fat, 75-g carbohydrate and 35-g protein) as breakfast, lunch and dinner. Blood sampling was performed just before each meal, and 4 and 8 h after the last meal. HDL and LDL were isolated by ultracentrifugation and analyzed for their composition, particle diameter and functional properties. Results: Postprandial triglycerides levels in plasma, HDL and LDL particles increased significantly in all groups (Po0.01). Compared with the control subjects, patients with T2DM had smaller LDL particles, and in agreement, a lower cholesterol-toprotein content in both fasting and postprandial samples. A prolonged increase in susceptibility of LDL to oxidation was found in all subjects, but was most evident in T2DM. The postprandial effect on LDL oxidation was associated with an increase in LDL triglyceride (r ¼ 0.29, Po0.05). In T2DM the anti-oxidative capacity of HDL trended to impairment after the third meal. Conclusions: Postprandial increases in triglycerides, especially in T2DM, are accompanied by pro-atherosclerotic functional changes in HDL and LDL particles.

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Elevated Endothelial Microparticles Following Consecutive Meals Are Associated With Vascular Endothelial Dysfunction in Type 2 Diabetes

Cited by 55 publications

References 16 publications

Microvesicles and diabetic complications — novel mediators, potential biomarkers and therapeutic targets

Microvesicles and diabetic complications — novel mediators, potential biomarkers and therapeutic targets

Leukocyte-Derived Microparticles in Vascular Homeostasis

Effect of three consecutive meals on the physicochemical properties of HDL and LDL in individuals with the metabolic syndrome and patients with type 2 diabetes

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