Elevated EGF Levels in the Blood Serum of Dogs with Periodontal Diseases and Oral Tumours

Sobczyńska-Rak, Aleksandra; Żylińska, Beata; Polkowska, Izabela; Szponder, Tomasz

doi:10.21873/invivo.11268

Cited by 3 publications

(3 citation statements)

References 21 publications

(24 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is also involved in the regulation of tissue immune response, inhibits collagen synthesis by fibroblasts and affects osteoclast bone resorption, which plays an important role in periodontitis [ 24 , 26 , 27 ]. High levels of EGF can be detected in patients with oral diseases and are believed to be closely related to the occurrence and development of periodontitis [ 28 ]. Consideringly, it was deduced that rs2237051 AA genotype may promote the expression level of EGF in cases that underwent dental implant, further contribute to inflammation and the risk of peri-implantitis.…”

Section: Discussionmentioning

confidence: 99%

Genetic association of the epidermal growth factor gene polymorphisms with peri-implantitis risk in Chinese population

et al. 2021

View full text Add to dashboard Cite

Peri-implant disease is an inflammatory disease and is related to genetic heterogeneity. Considering the genetic association of epidermal growth factor (EGF) gene polymorphisms with the susceptibility of periodontitis, its genetic association with peri-implantitis risk in a Chinese Han population was explored. 300 individuals who underwent dental implants were recruited, and divided into healthy implant group and peri-implantitis group. The genotype and allele distribution of EGF gene rs2237051 and rs4444903 polymorphisms were analyzed via direct sequencing and the frequencies were compared between the two groups using chi-square test. No significant difference was detected for the clinical information between healthy implant group and peri-implantitis group, including lifestyle habits platform type and position, peri-implant phenotype, brushing time, dental floss and mouth washing frequencies. Individuals with peri-implantitis had poor periodontal status. The GG genotype and G allele of rs2237051 showed significant increasing trend in peri-implantitis group compared with the healthy implant group. Compared with the AA genotype carriers, rs2237051 GG genotype carriers showed lower risk to suffer from peri-implantitis (OR=0.236, 95%CI=0.089-0.624), and possessed low values of gingival index, plaque index and calculus index, peri-implant pocket depth (PPD) and clinical attachment level (CAL). But there was no significant difference for the rs4444903 genotype distributions between the case and control groups. In summary, EGF rs2237051 polymorphism showed close association with the genetic background of peri-implantitis. Rs2237051 GG genotype and G allele might be protective factors for the onset of peri-implantitis.

show abstract

Section: Discussionmentioning

confidence: 99%

Genetic association of the epidermal growth factor gene polymorphisms with peri-implantitis risk in Chinese population

et al. 2021

View full text Add to dashboard Cite

show abstract

“…EGF is found in colostrum and milk and engages in a broad range of bioactivities in the intestinal epithelium including cellular proliferation, differentiation, and maturation (Playford & Wright, 1996). EGF is involved in many biological processes including healing of mucosa and skin and is produced at many sites along the intestinal tract, in saliva and in bile (Playford & Wright, 1996;Sobczyńska-Rak et al, 2018). The addition of EGF to bovine cell cultures has resulted in the inhibition of differentiation (Allen & Boxhorn, 1987;Greene & Allen, 1991).…”

Section: Mode Of Actionmentioning

confidence: 99%

A review on the safety of growth factors commonly used in cultivated meat production

Huang,

Ko,

Paes

et al. 2024

Comp Rev Food Sci Food Safe

View full text Add to dashboard Cite

Growth factors are commonly added to cell culture media in cellular agriculture to mimic the endogenous process of proliferation and differentiation of cells. Many of these growth factors are endogenous to humans and known to be present in the edible tissues and milk of food animals. However, there is little or no information on the use of growth factors intentionally added in food production before the advent of cultivated meat. Ten commonly used growth factors have been reviewed to include information on their mode of action, bioavailability, occurrence in food and food animals, endogenous levels in humans, as well as exposure and toxicological information drawn from relevant animal studies and human clinical trials with a focus on oral exposure. In addition, a comparison of homology of growth factors was done to compare the sequence homology of growth factors from humans and domestic animal species commonly consumed as food, such as bovine, porcine, and poultry. This information has been gathered as the starting point to determine the safety of use of growth factors in cultivated meat meant for human consumption. The change in levels of growth factors measured in human milk and bovine milk after pasteurization and high‐temperature treatment is discussed to give an indication of how commercial food processing can affect the levels of growth factors in food. The concept of substantial equivalence is also discussed together with a conservative exposure estimation. More work on how to integrate in silico assessments into the routine safety assessment of growth factors is needed.

show abstract

“…SOBCZYŃSKA-RAK, 2018).A inflamação crônica de dentes, espaço periodontal e mucosa oral podem predispor ao desenvolvimento de neoplasias. Os tumores orais constituem um grupo relativamente homogêneo com a maioria dos casos diagnosticados como tumores epiteliais, incluindo principalmente o carcinoma de células escamosas.…”

unclassified

Aspectos etiológicos e epidemiológicos do melanoma de mucosa oral de cães

Carvalho¹

View full text Add to dashboard Cite

Elevated EGF Levels in the Blood Serum of Dogs with Periodontal Diseases and Oral Tumours

Abstract: Abstract. Background

Cited by 3 publications

References 21 publications

Genetic association of the epidermal growth factor gene polymorphisms with peri-implantitis risk in Chinese population

Genetic association of the epidermal growth factor gene polymorphisms with peri-implantitis risk in Chinese population

A review on the safety of growth factors commonly used in cultivated meat production

Aspectos etiológicos e epidemiológicos do melanoma de mucosa oral de cães

Contact Info

Product

Resources

About