“…Since the systemic signs appearing in acute AIA mostly exceed those observed upon systemic immunization, systemic MPS activation appears to be an integral pathogenetic feature of this local arthritis model, presumably driven by leakage of antigen and pro-inflammatory stimuli from the inflamed joints. This systemic feature of arthritis can clearly be observed also in human RA [27,48,49], and makes systemic counteraction of MPS activation an attractive target for therapeutic intervention [50,51].…”