Elevated creative phosphokinase with isotretinoin

Correspondence

“…There have been a few reports, however, of the association between elevated serum CK levels and Isotretinoin treatment 5–9 …”

“…Although there have been a few reports of elevated serum CK levels with Isotretinoin treatment, 5–9 many of these patients had a recent history of strainful exercise or an intramuscular injection, and the elevation of CK was not firmly established as directly resulting from this treatment. Tillman et al 6 .…”

Creatine phosphokinase values during isotretinoin treatment for acne

“…Isotretinoin is an effective therapy for nodulocystic acne and has many known side effects. However, its association with elevated creatine phosphokinase (CPK) levels and its potential to cause rhabdomyolysis is not well established 1 …”

“…Muscle‐related complaints and high CPK blood levels have been reported in 15–50% of patients with acne treated with isotretinoin 1–5 . In the majority of cases, the abnormal CPK levels were increased two to four times the normal values 6–10 .…”

“…In the majority of cases, the abnormal CPK levels were increased two to four times the normal values 6–10 . Usually, they were found incidentally on routine blood tests because most patients were free of muscle symptoms 1–4,7,9,11 . Many of these patients had a recent history of strainful exercise or an intramuscular injection, and the elevation of CPK was not firmly established as directly resulting from this treatment 12 .…”