Elevated concentration of asymmetric dimethylarginine (ADMA) in individuals with metabolic syndrome

Palomo, Iván; Contreras, Angélica; Alarcón, L. Marcelo; Leiva, Elba; Guzmán, Luís; Mujica, Verónica; Icaza, Gloria; Díaz, Nora; González, Daniel; Moore‐Carrasco, Rodrigo

doi:10.1016/j.niox.2011.03.002

Cited by 56 publications

(42 citation statements)

References 32 publications

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“…Obesity, with or without the metabolic syndrome, has been associated with higher plasma ADMA levels, and concomitantly asthma has been linked to having lower L-arginine plasma levels (12,18,22,23); it is therefore possible that the combination of these conditions synergistically results in even lower L-arginine/ ADMA ratios. Therefore, as BMI increases in subjects with asthma, a reduced L-arginine/ADMA results in greater airway epithelial iNOS uncoupling.…”

Section: Discussionmentioning

confidence: 99%

An Association between l-Arginine/Asymmetric Dimethyl Arginine Balance, Obesity, and the Age of Asthma Onset Phenotype

Holguín

Comhair

Hazen

et al. 2013

Am J Respir Crit Care Med

149

114

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Rationale: Increasing body mass index (BMI) has been associated with less fractional exhaled nitric oxide (FE NO ). This may be explained by an increase in the concentration of asymmetric dimethyl arginine (ADMA) relative to L-arginine, which can lead to greater nitric oxide synthase uncoupling. Objectives: To compare this mechanism across age of asthma onset groups and determine its association with asthma morbidity and lung function. The log of plasma L-arginine/ADMA was inversely correlated with BMI in the late-(r ¼ 20.4, P ¼ 0.0006) in contrast to the early-onset phenotype (r ¼ 20.2, P ¼ 0.07). Although FE NO was inversely associated with BMI in the late-onset phenotype (P ¼ 0.02), the relationship was lost after adjusting for L-arginine/ADMA. Also in this phenotype, a reduced L-arginine/ADMA was associated with less IgE, increased respiratory symptoms, lower lung volumes, and worse asthma quality of life. Conclusions: In late-onset asthma phenotype, plasma ratios of L-arginine to ADMA may explain the inverse relationship of BMI to FE NO . In addition, these lower L-arginine/ADMA ratios are associated with reduced lung function and increased respiratory symptom frequency, suggesting a role in the pathobiology of the late-onset phenotype.Keywords: asthma; obesity; age of asthma onset; ADMA; arginine The extent to which obesity affects the health of people with asthma, and by what mechanisms, remains largely undetermined. Although adiposity imposes an important load on the respiratory system, beyond worsening dyspnea, there is little evidence that obesity affects asthma by increasing traditional biomarkers of airway inflammation or bronchial hyperresponsiveness. In fact, increasing body mass index (BMI) has been paradoxically associated with reduced levels of fractional exhaled nitric oxide (FE NO ) and sputum eosinophils (1-4). In addition, cluster analyses identify obesity as part of a phenotype characterized by less atopy and adult-onset asthma, with additional analyses suggesting obesity may be causally related to asthma among those with adult-onset asthma with less atopy (5, 6). In contrast, in those with childhood-onset more atopic asthma, the asthma appears to be causative for the weight gain (7). This difference in relationship among early-and late-onset asthma was conditionally confirmed in a study of obese subjects with asthma undergoing bariatric surgery (8). Loss of body weight improved respiratory Author Contributions: Contributed to manuscript preparation and design: F.H., S.S.K., S.C.E., S.E.W. Analyzed samples: S.C.E., R.W.P., S.L.H., S.A.A.C. Contributed with participant recruitment/sample: S.S.K., E.R.B., W.W.B., W.J.C., M.C., A.M.F., B.G., E.I., N.N.J., W.C.M., S.P.P., W.G.T., K.F.C., S.C.E., S.E.W.Correspondence and requests for reprints should be addressed to Fernando Holguin, M.D., M.P.H., Asthma Institute, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, MUH 628, 3459 Fifth Avenue, Pittsburgh, PA 15213. E-mail: holguinf@upmc.edu This article has an on...

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Section: Discussionmentioning

confidence: 99%

An Association between l-Arginine/Asymmetric Dimethyl Arginine Balance, Obesity, and the Age of Asthma Onset Phenotype

Holguín

Comhair

Hazen

et al. 2013

Am J Respir Crit Care Med

149

114

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“…In one study, ADMA levels were found to be higher in patients with metabolic syndrome compared with normal subjects, but no correlation was found between ADMA and cholesterol levels (20). In another study of ESRD patients, ADMA showed significant correlation with serum cholesterol levels (19).…”

Section: Discussionmentioning

confidence: 99%

Asymmetric dimethyl arginine levels in chronic hemodialysis patients

Çi̇fci̇¹,

İnal²,

Kaya³

2014

Turk J Med Sci

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“…Endothelial dysfunction expresses adhesion molecules on cell surfaces and synthesizes plasma proteins such as von Willebrand factor (vWF) that are involved in platelet adhesion during thrombosis and inflammation (Kanaji et al 2012, Etingin et al 1993, Palomo et al 2011.…”

Section: Endothelial Functionmentioning

confidence: 99%

Mechanisms of Endothelial Protection by Natural Bioactive Compounds from Fruit and Vegetables

Monsalve

Concha-Meyer

Palomo

et al. 2017

An. Acad. Bras. Ciênc.

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The endothelium is fundamental for the regulation of vascular tone and structure. Under disease conditions, including the presence of cardiovascular disease risk factors, the endothelium loses its protective role and becomes a proatherosclerotic structure. In this article we searched for strategies from PUBMED and Science Direct databases using the following key words: endothelium, natural bioactive compounds, polyphenols and cardiovascular diseases. The search was restricted to english language papers. Studies have identified the contribution of diet to the risk of developing cardiovascular diseases. In this context, high intakes of fruit and vegetables are associated with the decrease of cardiovascular diseases. Thus the most important fruit/vegetables and bioactive compounds to prevent endothelial diseases are berries, apples, virgin olive oil, tomatoes, soybeans, and polyphenols, carotenoids and unsaturated fatty acids, respectively. The bioactive compounds from fruit and vegetables provide endothelial protection through the following mechanisms: improved eNOS/NO bioavailability, attenuates oxidative stress, inhibited NF-κB pathway and decreased cell adhesion molecules expression. In this article natural bioactive compound mechanisms of endothelium protection are thoroughly reviewed.

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Elevated concentration of asymmetric dimethylarginine (ADMA) in individuals with metabolic syndrome

Cited by 56 publications

References 32 publications

An Association between l-Arginine/Asymmetric Dimethyl Arginine Balance, Obesity, and the Age of Asthma Onset Phenotype

An Association between l-Arginine/Asymmetric Dimethyl Arginine Balance, Obesity, and the Age of Asthma Onset Phenotype

Asymmetric dimethyl arginine levels in chronic hemodialysis patients

Mechanisms of Endothelial Protection by Natural Bioactive Compounds from Fruit and Vegetables

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