Elevated circulating irisin is associated with lower risk of insulin resistance: association and path analyses of obese Chinese adults

Shi, Xiulin; Lin, Mingzhu; Liu, Chunlu; Xiao, Fangsen; Liu, Yongwen; Huang, Peiying; Zeng, Xin; Yan, Bing; Liu, Suhuan; Li, Xiaoying; Yang, Shuyu; Li, Xuejun; Li, Zhibin

doi:10.1186/s12902-016-0123-9

Cited by 36 publications

(31 citation statements)

References 32 publications

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“…33 Our study was the first to show that CPAP over 3 months could increase irisin level modestly after controlling the obesity factor. Elevated irisin was shown to be associated with lower risk of insulin resistance 34 and the compositions of skeletal muscle and visceral fat. 35 Further studies will help to clarify the association of irisin in OSA and its effect after CPAP.…”

Section: Discussionmentioning

confidence: 99%

Effects of CPAP therapy on visceral fat thickness, carotid intima‐media thickness and adipokines in patients with obstructive sleep apnoea

Liu

et al. 2016

Respirology

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Section: Discussionmentioning

confidence: 99%

Effects of CPAP therapy on visceral fat thickness, carotid intima‐media thickness and adipokines in patients with obstructive sleep apnoea

Liu

et al. 2016

Respirology

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“…; Shi et al. ) and significantly lower in individuals with Type 2 diabetes, (Moreno‐Navarrete et al. ) data from a meta‐analysis (Qiu et al.…”

Section: Discussionmentioning

confidence: 99%

Exercise‐induced irisin release as a determinant of the metabolic response to exercise training in obese youth: the EXIT trial

et al. 2017

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The mechanisms underlying the metabolic improvements following aerobic exercise training remain poorly understood. The primary aim of this study was to determine if an adipomyokine, irisin, responded to acute exercise was associated with the metabolic adaptations to chronic aerobic exercise in obese youth. The acute response to exercise was assessed in 11 obese youth following 45‐min acute bouts of aerobic (AE) and resistance exercise (RE). The irisin area under the curve (pre‐exercise, 15, 30, and 45 min) during these AE sessions were the main exposure variables. The primary outcome measure was the change in insulin sensitivity using the Matsuda index, following 6 weeks of RE training, delivered for 45 min, three times per week at 60–65% 1RM. Participants were also categorized as either responders (above) or nonresponders (below) based on the percentage change in the Matsuda index following the 6‐week intervention. Irisin increased significantly during the acute bout of AE from 29.23 ± 6.96 to 39.30 ± 7.05 ng/mL; P = 0.028, but not significantly during the RE session (P = 0.182). Absolute and relative change in irisin during the acute bout of AE was associated with absolute and relative change in Matsuda index (r = 0.68; P = 0.022 and r = 0.63; P = 0.037) following the 6‐week RE intervention. No such association was observed with the irisin response to acute RE (all P > 0.05). Responders to the 6‐week RE intervention displayed a fourfold greater irisin response to acute AE (90.0 ± 28.0% vs. 22.8 ± 18.7%; P = 0.024) compared to nonresponders. Irisin increases significantly following an acute bout of AE, but not RE, and this response is associated with a greater improvement in insulin sensitivity in response to chronic resistance training.

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“…2016; Shi et al. 2016), but results are contradictory. Although several studies have shown irisin to be positively associated with insulin resistance (Park et al.…”

Section: Introductionmentioning

confidence: 99%

Increased FNDC5 is associated with insulin resistance in high fat-fed mice

et al. 2017

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FNDC5/irisin, has recently been identified as a novel protein that stimulates the “browning” of white adipose by inducing thermogenesis via increased uncoupling protein 1 (UCP1). We tested the hypothesis that high fat diet‐induced prediabetic mice would exhibit increased FNDC5 and this effect would be attenuated by chronic exercise. C57BL/6 mice were randomized into three groups for the 4 week intervention: Standard diet (Std, n = 12), High fat diet (HF, n = 14), or High fat diet and free access to a running wheel (HFEX, n = 14). Body weight, glucose, insulin, and the homeostatic model assessment of insulin resistance (HOMA‐IR) were greater in HF compared to Std and HFEX after the 4 week intervention. In support of our hypothesis, FNDC5 was higher in HF in both skeletal muscle and adipose compared to Std and was lower in adipose only in HFEX compared to HF mice. Following the same pattern, PGC‐1α was significantly higher in HF compared to Std in skeletal muscle and significantly lower in HFEX compared to HF in adipose. UCP1 was significantly lower in HFEX versus Std (in skeletal muscle) and versus HF (in adipose). HOMA‐IR was significantly correlated with FNDC5 protein levels in adipose. Increased FNDC5 in adipose and skeletal muscle may be a compensatory mechanism to offset high fat diet‐induced weight gain and insulin resistance by increasing energy expenditure.

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Elevated circulating irisin is associated with lower risk of insulin resistance: association and path analyses of obese Chinese adults

Cited by 36 publications

References 32 publications

Effects of CPAP therapy on visceral fat thickness, carotid intima‐media thickness and adipokines in patients with obstructive sleep apnoea

Effects of CPAP therapy on visceral fat thickness, carotid intima‐media thickness and adipokines in patients with obstructive sleep apnoea

Exercise‐induced irisin release as a determinant of the metabolic response to exercise training in obese youth: the EXIT trial

Increased FNDC5 is associated with insulin resistance in high fat-fed mice

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