Elevated circulating asymmetric dimethylarginine levels in rheumatoid arthritis: a systematic review and meta-analysis

Zhao, Chan-Na; Wu, Qian; Mao, Yan-Mei; Liu, Lina; Dan, Yi-Lin; Li, Xiaomei; Wang, Deguang; Pan, Hai‐Feng

doi:10.1007/s00726-019-02714-5

Cited by 6 publications

(4 citation statements)

References 45 publications

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“…It should also be mentioned that RA-ILD + patients presented the lowest PRMT1 expression, probably as a result of post-transcriptional regulatory mechanisms ( Greenbaum et al, 2003 ; Stevens and Brown, 2013 ; Li et al, 2020 ). Furthermore, PRMT1 expression was positively correlated with RA duration in RA-ILD + patients, confirming its previously described relationship with RA ( Sandoo et al, 2012 ; Dimitroulas and Kitas, 2019 ; Zhao et al, 2019 ).…”

Section: Discussionsupporting

confidence: 87%

“…In this sense, key factors in the vasculopathy and inflammatory response include vascular cell adhesion molecule-1 (VCAM-1), one of the main responsibles of the firm adhesion of leukocytes to the endothelium ( Dessein et al, 2005 ; Navarro-Hernández et al, 2009 ; Murdaca et al, 2012 ; Steyers and Miller, 2014 ; Wang et al, 2015 ; Kong et al, 2018 ), and the monocyte chemoattractant protein-1 (MCP-1), a chemokine that regulates the endothelial transmigration of monocyte ( Hayashida et al, 2001 ; Rantapää-Dahlqvist et al, 2007 ; Deshmane et al, 2009 ; Dessein et al, 2013 ; Yang et al, 2016 ). Besides, asymmetric dimethylarginine (ADMA) is also involved in these disorders, regulating the vascular tone and inhibiting the nitric oxide synthesis ( Dimitroulas et al, 2012 ; Murdaca et al, 2012 ; Steyers and Miller, 2014 ; Dimitroulas and Kitas, 2019 ; Zhao et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

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Elevated VCAM-1, MCP-1 and ADMA serum levels related to pulmonary fibrosis of interstitial lung disease associated with rheumatoid arthritis

Pulito‐Cueto

Remuzgo‐Martínez

Genre

et al. 2022

Front. Mol. Biosci.

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Introduction: Early diagnosis of interstitial lung disease (ILD) associated with rheumatoid arthritis (RA) constitutes a challenge for the clinicians. Pulmonary vasculopathy is relevant in the development of interstitial lung disease. Accordingly, we aimed to explore the role of vascular cell adhesion molecule-1 (VCAM-1), monocyte chemoattractant protein-1 (MCP-1) and asymmetric dimethylarginine (ADMA), key molecules in the vasculopathy, as potential biomarkers of pulmonary fibrosis in RA-ILD+.Methods: We included 21 RA-ILD+ patients and two comparative groups: 25 RA-ILD- patients and 21 idiopathic pulmonary fibrosis (IPF) patients. Serum levels of the molecules were determined by ELISA, and mRNA expression was quantified by qPCR.Results: VCAM-1, MCP-1 and ADMA serum levels were increased in RA-ILD+ patients in relation to RA-ILD- and IPF patients. Additionally, RA-ILD+ patients exhibited increased CCL2 (gene encoding MCP-1) and decreased PRMT1 (gene related to ADMA synthesis) mRNA expression in relation to RA-ILD- patients. A lower expression of VCAM1, CCL2, and PRMT1 was observed in RA-ILD+ patients when compared with those with IPF. Furthermore, MCP-1 serum levels and PRMT1 mRNA expression were positively correlated with RA duration, and ADMA serum levels were positively associated with C-reactive protein in RA-ILD+ patients.Conclusion: Our study suggests that VCAM-1, MCP-1 and ADMA could be considered as useful biomarkers to identify ILD in RA patients, as well as to discriminate RA-ILD+ from IPF, contributing to the early diagnosis of RA-ILD+.

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Elevated VCAM-1, MCP-1 and ADMA serum levels related to pulmonary fibrosis of interstitial lung disease associated with rheumatoid arthritis

Pulito‐Cueto

Remuzgo‐Martínez

Genre

et al. 2022

Front. Mol. Biosci.

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“…ADMA has been associated with several vascular diseases, such as coronary artery disease(36), preeclampsia (37), chronic kidney diseases, and carotid intima-media thickness(38), and is considered a prognostic marker of all-cause mortality(39) and a predictor of early-onset atherosclerosis (40).…”

Section: Discussionmentioning

confidence: 99%

Increased Asymmetric Dimethylarginine In Patients With Hypertension: A Systematic Review And Meta-Analysis

Chen

Xia

Tao

et al. 2022

Preprint

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Background: Hypertension is the leading risk factor for vascular diseases, such as coronary artery disease, arterial stiffness, and stroke. Elevated asymmetric dimethylarginine (ADMA) levels have been reported to be an independent predictor of all-cause mortality. However, the role of ADMA in hypertension remains undetermined. To derive a more accurate estimate of circulating ADMA levels in hypertension patients, a meta-analysis was performed. Result: The Embase, PubMed, Cochrane Library, and Web of Science databases were searched (up to October 10, 2021) for relevant published literature. To assess study heterogeneity, Cochran’s Q and the I2 statistic were calculated. Publication bias was evaluated using a funnel plot. A total of 1951 articles were identified, of which 28 studies with 2694 subjects (1534 hypertension patients and 1160 healthy controls) were ultimately included. Plasma/serum ADMA levels were found to be higher in hypertension patients than in healthy controls (standard mean difference = 1.27, 95% confidence interval [0.99, 1.54]). Conclusion: Therefore, strategies aimed at reducing ADMA may constitute an effective therapeutic approach to prevent the development of hypertension in patients.

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“…As alternative approach, mismatch hybridization strategies for SNP detection has been developed in previous studies for longer RNA targets [ 1 , 8 ]. In situ PCR in combination with FISH has also been developed to enable simultaneous detection of point mutations and copy number variations at single-cell level in cancer tissue samples [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Mutations in microRNA-128-2-3p identified with amplification-free hybridization assay

Slott,

Krüger-Jensen,

Ferreira da Silva

et al. 2023

PLoS ONE

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We describe a quantitative detection method for mutated microRNA in human plasma samples. Specific oligonucleotides designed from a Peyrard-Bishop model allowed accurate prediction of target:probe recognition affinity and specificity. Our amplification-free tandem bead-based hybridization assay had limit of detection of 2.2 pM. Thereby, the assay allowed identification of single-nucleotide polymorphism mismatch profiles in clinically relevant microRNA-128-2-3p, showing terminal mutations that correlate positively with inflammatory colitis and colorectal cancer.

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Elevated circulating asymmetric dimethylarginine levels in rheumatoid arthritis: a systematic review and meta-analysis

Cited by 6 publications

References 45 publications

Elevated VCAM-1, MCP-1 and ADMA serum levels related to pulmonary fibrosis of interstitial lung disease associated with rheumatoid arthritis

Elevated VCAM-1, MCP-1 and ADMA serum levels related to pulmonary fibrosis of interstitial lung disease associated with rheumatoid arthritis

Increased Asymmetric Dimethylarginine In Patients With Hypertension: A Systematic Review And Meta-Analysis

Mutations in microRNA-128-2-3p identified with amplification-free hybridization assay

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