Elevated childhood exposure to arsenic despite reduced drinking water concentrations — A longitudinal cohort study in rural Bangladesh

Kippler, Maria; Skröder, Helena; Rahman, Syed Moshfiqur; Tofail, Fahmida; Vahter, Marie

doi:10.1016/j.envint.2015.10.017

Cited by 73 publications

(31 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A great amount of arsenic is removed during the rice polishing [ 21 , 50 – 52 ]. Besides, variation in the arsenic concentration may occur due to different cultivars, geography, environment, water quality, and growth conditions [ 21 , 24 , 25 , 29 , 30 , 37 , 51 , 53 – 56 ].…”

Section: Resultsmentioning

confidence: 99%

“…The results found in this study on the total arsenic contents were also in agreement with those previously reported for rice analyzed in other countries ( Table 7 ). The exception is for arsenic concentration found in rice cultivated in Bangladesh, one of the countries that have been mostly vulnerable to arsenic exposure, causing a serious Public Health problem [ 33 , 34 , 53 ]. In the 1970s, the plumbing pipes contaminated by arsenic were installed in the country, and it caused the contamination of the water consumed by the population.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Total Arsenic, Cadmium, and Lead Determination in Brazilian Rice Samples Using ICP-MS

Mataveli

Buzzo

Arauz

et al. 2016

Journal of Analytical Methods in Chemistry

View full text Add to dashboard Cite

This study is aimed at investigating a suitable method for rice sample preparation as well as validating and applying the method for monitoring the concentration of total arsenic, cadmium, and lead in rice by using Inductively Coupled Plasma Mass Spectrometry (ICP-MS). Various rice sample preparation procedures were evaluated. The analytical method was validated by measuring several parameters including limit of detection (LOD), limit of quantification (LOQ), linearity, relative bias, and repeatability. Regarding the sample preparation, recoveries of spiked samples were within the acceptable range from 89.3 to 98.2% for muffle furnace, 94.2 to 103.3% for heating block, 81.0 to 115.0% for hot plate, and 92.8 to 108.2% for microwave. Validation parameters showed that the method fits for its purpose, being the total arsenic, cadmium, and lead within the Brazilian Legislation limits. The method was applied for analyzing 37 rice samples (including polished, brown, and parboiled), consumed by the Brazilian population. The total arsenic, cadmium, and lead contents were lower than the established legislative values, except for total arsenic in one brown rice sample. This study indicated the need to establish monitoring programs for emphasizing the study on this type of cereal, aiming at promoting the Public Health.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Total Arsenic, Cadmium, and Lead Determination in Brazilian Rice Samples Using ICP-MS

Mataveli

Buzzo

Arauz

et al. 2016

Journal of Analytical Methods in Chemistry

View full text Add to dashboard Cite

show abstract

“…Exposures to arsenic and manganese among infants and mothers often occur via additional dietary sources outside of drinking water, so our reliance on this metric likely means we underestimated the true exposure levels. However, contaminated drinking water is the primary source of elevated exposures to arsenic and manganese in Bangladesh [84,96]. Breastfeeding can reduce postnatal exposures, as arsenic and manganese are not fat soluble and typically not found in high concentrations in breast milk [47,48].…”

Section: Discussionmentioning

confidence: 99%

Evaluating the effects between metal mixtures and serum vaccine antibody concentrations in children: a prospective birth cohort study

et al. 2020

View full text Add to dashboard Cite

Background: Many populations are exposed to arsenic, lead, and manganese. These metals influence immune function. We evaluated the association between exposure to single and multiple metals, including arsenic, lead, and manganese, to humoral immunity as measured by antibody concentrations to diphtheria and tetanus toxoid among vaccinated Bangladeshi children. Additionally, we examined if this association was potentially mediated by nutritional status. Methods: Antibody concentrations to diphtheria and tetanus were measured in children's serum at age 5 (n = 502). Household drinking water was sampled to quantify arsenic (W-As) and manganese (W-Mn), whereas lead was measured in blood (B-Pb). Exposure samples were taken during pregnancy, toddlerhood, and early childhood. Multiple linear regression models (MLRs) with single or combined metal predictors were used to determine the association with antibody outcomes. MLR results were transformed to units of percent change in outcome per doubling of exposure to improve interpretability. Structural equation models (SEMs) were used to further assess exposure to metal mixtures. SEMs regressed a latent exposure variable (Metals), informed by all measured metal variables (W-As, W-Mn, and B-Pb), on a latent outcome variable (Antibody), informed by measured antibody variables (diphtheria and tetanus). Weight-forage z-score (WFA) at age 5 was evaluated as a mediator.

show abstract

“…Apart from occupational exposure, one of the most important environmental routes of exposure is drinking As‐contaminated water. Based on arsenic permissible limits 0.01 mg L −1 , several countries are still confronted with challenge and health risk, including China, 1 Bangladesh, 2 Argentina, 3 India, 4 Vietnam, 5,6 and the United States 7 . The other major source is As‐contaminated air and food caused by combustion high As‐containing coal in unventilated indoor stoves for cooking, which has been exclusively reported in Guizhou province in China in 2002 year 8 .…”

Section: Introductionmentioning

confidence: 99%

ROS‐mediated PERK‐eIF2α‐ATF4 pathway plays an important role in arsenite‐induced L‐02 cells apoptosis via regulating CHOP‐DR5 signaling

Liu

Zhang

2020

Environmental Toxicology

View full text Add to dashboard Cite

Chronic exposure to arsenic remains a worldwide environmental health issue, affecting hundreds of millions of people. Although, arsenic‐induced oxidative stress and apoptosis have been determined, the underlying apoptosis mechanism has not been fully elucidated yet. Oxidative stress integrated‐ER stress plays an important role in Life‐and‐Death decision of cells. The current study was to investigate whether NaAsO2 utilizes oxidative stress integrated‐ER stress signaling to exert pro‐apoptotic activity in L‐02 cells. Results showed that death receptor 5 (DR5) was a mediator of NaAsO2‐induced apoptosis by enhancing construction of the death‐inducing signaling complex (DISC). NaAsO2‐sensitized DR5 elevation required maintainable transcription and its transcription factor C/EBP homologous protein (CHOP). Further results showed that NaAsO2 increased expression in biomarker of endoplasmic reticulum (ER) stress and activated the protein kinase R‐like ER kinase (PERK)‐eukaryotic translation initiation 2α (eIF2α)‐activating transcription factor 4 (ATF4) pathway. PERK inhibitor and ATF4 siRNA significantly attenuated NaAsO2‐induced CHOP and DR5 expressions. In addition, the antioxidant N‐acetyl‐l‐cysteine (NAC) treatment led to amelioration of NaAsO2‐induced production of reactive oxygen species (ROS) and some ER stress‐ and apoptosis‐ related protein levels and cell viability. Taken together, the results indicate that ROS‐mediated PERK‐eIF2α‐ATF4 pathway activated by NaAsO2 is the critical upstream event for subsequent apoptosis induction via regulating CHOP‐DR5 signaling in L‐02 cells when chronic exposure to arsenic, and support that antioxidants might be potential therapeutic agents for preventing or delaying the onset and progress of arsenic‐induced hepatotoxicity.

show abstract

Elevated childhood exposure to arsenic despite reduced drinking water concentrations — A longitudinal cohort study in rural Bangladesh

Abstract: Despite decreased water arsenic concentrations in rural Bangladesh, the children still have elevated exposure, largely from food. Considering the known risks of severe health effects in children, additional mitigation strategies are needed.

Cited by 73 publications

References 51 publications

Total Arsenic, Cadmium, and Lead Determination in Brazilian Rice Samples Using ICP-MS

Total Arsenic, Cadmium, and Lead Determination in Brazilian Rice Samples Using ICP-MS

Evaluating the effects between metal mixtures and serum vaccine antibody concentrations in children: a prospective birth cohort study

ROS‐mediated PERK‐eIF2α‐ATF4 pathway plays an important role in arsenite‐induced L‐02 cells apoptosis via regulating CHOP‐DR5 signaling

Contact Info

Product

Resources

About