Elevated CAIX Expression Is Associated with an Increased Risk of Distant Failure in Early-Stage Cervical Cancer

Kirkpatrick, John P.; Rabbani, Zahid N.; Bentley, Rex C.; Hardee, Matthew E.; Karol, Seth E.; Meyer, Jeffrey; Oosterwijk, Egbert; Havrilesky, Laura J.; Secord, Angeles Alvarez; Vujaskovic, Z.; Dewhirst, Mark W.; Jones, E. L.

doi:10.1016/j.ijrobp.2005.07.364

Cited by 14 publications

(20 citation statements)

References 6 publications

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“…Across all cancer types, CA9 had the highest average oncogene score on Chromosome 9. CA9 is a known hypoxia marker and cancer drug target20, contributes to AKT activation in kidney cancer21 and is associated with distant metastasis in early-stage cervical cancer if highly expressed22, supporting its high oncogene score.…”

Section: Resultsmentioning

confidence: 94%

OncoScape: Exploring the cancer aberration landscape by genomic data fusion

Schlicker

Michaut

Rahman

et al. 2016

Sci Rep

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Although large-scale efforts for molecular profiling of cancer samples provide multiple data types for many samples, most approaches for finding candidate cancer genes rely on somatic mutations and DNA copy number only. We present a new method, OncoScape, which exploits five complementary data types across 11 cancer types to identify new candidate cancer genes. We find many rarely mutated genes that are strongly affected by other aberrations. We retrieve the majority of known cancer genes but also new candidates such as STK31 and MSRA with very high confidence. Several genes show a dual oncogene- and tumor suppressor-like behavior depending on the tumor type. Most notably, the well-known tumor suppressor RB1 shows strong oncogene-like signal in colon cancer. We applied OncoScape to cell lines representing ten cancer types, providing the most comprehensive comparison of aberrations in cell lines and tumor samples to date. This revealed that glioblastoma, breast and colon cancer show strong similarity between cell lines and tumors, while head and neck squamous cell carcinoma and bladder cancer, exhibit very little similarity between cell lines and tumors. To facilitate exploration of the cancer aberration landscape, we created a web portal enabling interactive analysis of OncoScape results (http://ccb.nki.nl/software/oncoscape).

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Section: Resultsmentioning

confidence: 94%

OncoScape: Exploring the cancer aberration landscape by genomic data fusion

Schlicker

Michaut

Rahman

et al. 2016

Sci Rep

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“…Similar to previous studies, the current study showed that positive CA-IX expression was related to frequent recurrence of cervical cancer. Other studies reported that positive CA-IX expression is strongly associated with DFS and metastasis-free survival in cervical cancer patients [7,8,21]. However, the prognostic implication of CA-IX expression in cervical cancer is controversial as there have been different clinical outcomes.…”

Section: Discussionmentioning

confidence: 99%

“…These sections were transferred to poly- L -lysine-coated glass slides and air-dried overnight at 37.8°C. The glass slides were dewaxed in xylene (3 changes), rehydrated in a graded series of decreasing ethanol concentrations, and then rinsed in Tris-buffered saline (50 mM Tris/HCl pH [7]. 4 containing 100 mM NaCl).…”

Section: Methodsmentioning

confidence: 99%

“…However, with the exception of the presence of LN metastasis, the accuracy of these traditional prognostic factors continues to be debated for patients with cervical cancer [5]. Recently, some studies have shown that the expression of various biological marker, including carbonic anhydrase-IX (CA-IX), glucose transporter GLUT-1, and angiogenetic factor, in cervical cancer patients was related to poor prognosis [6,7,8,9,10]. …”

Section: Introductionmentioning

confidence: 99%

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Additional Prognostic Value of SUV<sub>max</sub> Measured by F-18 FDG PET/CT over Biological Marker Expressions in Surgically Resected Cervical Cancer Patients

et al. 2015

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Purpose: We compared the prognostic ability of the maximum standardized uptake value (SUV_max) and various biological marker expressions to predict recurrence in patients with surgically resected cervical cancer. Methods: A retrospective review identified 60 patients with cervical cancer who received [¹⁸F]fluorodeoxyglucose positron emission tomography/computed tomography (F-18 FDG PET/CT) at the time of the diagnosis of cancer. The SUV_max, expressions of carbonic anhydrase-IX (CA-IX), glucose transporter 1 (GLUT-1), and vascular endothelial growth factor (VEGF), and known prognostic factors were investigated. Results: The median follow-up time was 22.2 months (range 3.4-43.1 months). Using univariate analyses, the stage (stage II, p = 0.0066), SUV_max (> 6, p = 0.027), parametrial involvement (p < 0.0001), and positivity for CA-IX (p = 0.0191) were associated with recurrences of cervical cancer. With the Cox proportional hazard regression model, the SUV_max was a potent predictor for disease-free survival (DFS). Conclusion: Although CA-IX expression was related to DFS in the current study, the potent predictor for DFS was SUV_max. Therefore, SUV_max is of greater prognostic value than biological marker expression in patients with surgically resected cervical cancer.

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“…The cytosolic isozymes are CA I, CA II, CA III, CA VII, and CA XIII, whereas CA IV, CA IX, CA XII, CA XIV, and CA XV are membrane bound isozymes, and CA VA and CA VB are mitochondrial isozymes; CA VI is secreted isozyme mainly present in the saliva [8]. There are certain physiological disorders that are characterized by overexpression of CA [9–11], hence CAs have emerged as valuable drug targets. Many clinically established drugs are CA inhibitors and are used to treat disorders such as glaucoma, acidic ulcers, mountain/sea sickness, and epilepsy [12].…”

Section: Introductionmentioning

confidence: 99%

Sulfa Drugs as Inhibitors of Carbonic Anhydrase: New Targets for the Old Drugs

al‐Rashida

Hussain

Hamayoun

et al. 2014

BioMed Research International

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Sulfa drugs are well-known antibacterial agents containing N-substituted sulfonamide group on para position of aniline ring (NH2RSO2NHR′). In this study 2,4-dichloro-1,3,5-triazine derivatives of sulfa drugs, sulfamerazine (1b), sulfaquinoxaline (2b), sulfadiazine (3b), sulfadimidine (4b), and sulfachloropyrazine (5b) (1a–5a) were synthesized and characterized. Their carbonic anhydrase inhibition activity was evaluated against bovine cytosolic carbonic anhydrase isozyme II (bCA II). For the sake of comparison the CA inhibition activity of the parent sulfa drugs (1b–5b) was also evaluated. A significant increase in CA inhibition activity of sulfa drugs was observed upon substitution with 2,4-dichloro-1,3,5-triazine moiety. Molecular docking studies were carried out to highlight binding site interactions. ADME properties were calculated to evaluate drug likeness of the compounds.

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Elevated CAIX Expression Is Associated with an Increased Risk of Distant Failure in Early-Stage Cervical Cancer

Cited by 14 publications

References 6 publications

OncoScape: Exploring the cancer aberration landscape by genomic data fusion

OncoScape: Exploring the cancer aberration landscape by genomic data fusion

Additional Prognostic Value of SUV<sub>max</sub> Measured by F-18 FDG PET/CT over Biological Marker Expressions in Surgically Resected Cervical Cancer Patients

Sulfa Drugs as Inhibitors of Carbonic Anhydrase: New Targets for the Old Drugs

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