Elevated c-Src and c-Yes expression in malignant skin cancers

Lee, Jang Hyun; Pyon, Jai‐Kyong; Kim, Dong Wook; Lee, Sang‐Han; Nam, Heerim; Kim, Chul Han; Kang, Sang Gue; Lee, Yoon Jin; Park, Mi Youn; Jeong, Dong Jun; Cho, Moon Kyun

doi:10.1186/1756-9966-29-116

Cited by 39 publications

(41 citation statements)

References 14 publications

(13 reference statements)

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“…In addition to known GBM-associated proteins, novel potential biomarkers identified in this study include CLIC4, NP1L1, IGKC, TAGL2, and YES (Supplementary Table S1). These proteins have been identified to be involved in processes promoting cancer progression but have never been previously associated with GBM (35,36,60,63,65). With further validations, these proteins may serve as novel therapeutic targets in GBM.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive characterization of glioblastoma tumor tissues for biomarker identification using mass spectrometry-based label-free quantitative proteomics

Heroux

Chesnik

Halligan

et al. 2014

Physiological Genomics

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Section: Discussionmentioning

confidence: 99%

Comprehensive characterization of glioblastoma tumor tissues for biomarker identification using mass spectrometry-based label-free quantitative proteomics

Heroux

Chesnik

Halligan

et al. 2014

Physiological Genomics

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“…SRC is the first cloned oncogene, and significant literature implicates SRC in human cancer, especially in skin SCC (Matsumoto et al 2003;Lee et al 2010;Sudol 2011). Nevertheless, the mechanisms of SRC oncogenic activity are still poorly understood, as the essential SRC phosphorylation targets responsible for cellular transformation have not been identified.…”

Section: Discussionmentioning

confidence: 99%

αE-catenin inhibits a Src–YAP1 oncogenic module that couples tyrosine kinases and the effector of Hippo signaling pathway

et al. 2016

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Cell-cell adhesion protein αE-catenin inhibits skin squamous cell carcinoma (SCC) development; however, the mechanisms responsible for this function are not completely understood. We report here that αE-catenin inhibits β4 integrin-mediated activation of SRC tyrosine kinase. SRC is the first discovered oncogene, but the protein substrate critical for SRC-mediated transformation has not been identified. We found that YAP1, the pivotal effector of the Hippo signaling pathway, is a direct SRC phosphorylation target, and YAP1 phosphorylation at three sites in its transcription activation domain is necessary for SRC-YAP1-mediated transformation. We uncovered a marked increase in this YAP1 phosphorylation in human and mouse SCC tumors with low/negative expression of αE-catenin. We demonstrate that the tumor suppressor function of αE-catenin involves negative regulation of the β4 integrin-SRC signaling pathway and that SRC-mediated phosphorylation and activation of YAP1 are an alternative to the canonical Hippo signaling pathway that directly connect oncogenic tyrosine kinase signaling with YAP1.

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“…5 and 6. DISCUSSION c-Yes, similar to other members of the SFKs (e.g., c-Src), is a (proto)oncogene, with its expression intimately related to carcinogenesis (11,29,53,57,58). For instance, overexpression of c-Yes in human colorectal carcinoma cells promotes metastatsis (3), but recent studies have shown that it also plays critical roles in different cellular physiological function, such as growth factor activation, endocytic vesicle-mediated protein trafficking, and cell signaling (11,15,68,69).…”

Section: Knockdown Of C-yes In the Testis In Vivo Disrupts Distributimentioning

confidence: 99%

“…c-Yes (or Yes 1, Yamaguchi sarcoma viral oncogene homolog 1), a nonreceptor protein tyrosine kinase and a member of the Src family kinases (SFKs) and also a proto-oncogene whose expression is upregulated in various cancers, including melanoma (29), colon cancer (58), and brain cancer (53), is also known to be involved in regulating cell cycle and cytokinesis (28). In fact, members of the SFKs are targets of chemotherapy (1,67).…”

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confidence: 99%

c-Yes regulates cell adhesion at the apical ectoplasmic specialization-blood-testis barrier axis via its effects on protein recruitment and distribution

Xiao

Mruk

Cheng

2013

American Journal of Physiology-Endocrinology and Metabolism

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During spermatogenesis, extensive restructuring takes place at the cell-cell interface since developing germ cells migrate progressively from the basal to the adluminal compartment of the seminiferous epithelium. Since germ cells per se are not motile cells, their movement relies almost exclusively on the Sertoli cell. Nonetheless, extensive exchanges in signaling take place between these cells in the seminiferous epithelium. c-Yes, a nonreceptor protein tyrosine kinase belonging to the Src family kinases (SFKs) and a crucial signaling protein, was recently shown to be upregulated at the Sertoli cell-cell interface at the blood-testis barrier (BTB) at stages VIII-IX of the seminiferous epithelial cycle of spermatogenesis. It was also highly expressed at the Sertoli cell-spermatid interface known as apical ectoplasmic specialization (apical ES) at stage V to early stage VIII of the epithelial cycle during spermiogenesis. Herein, it was shown that the knockdown of c-Yes by RNAi in vitro and in vivo affected both Sertoli cell adhesion at the BTB and spermatid adhesion at the apical ES, causing a disruption of the Sertoli cell tight junction-permeability barrier function, germ cell loss from the seminiferous epithelium, and also a loss of spermatid polarity. These effects were shown to be mediated by changes in distribution and/or localization of adhesion proteins at the BTB (e.g., occludin, N-cadherin) and at the apical ES (e.g., nectin-3) and possibly the result of changes in the underlying actin filaments at the BTB and the apical ES. These findings implicate that c-Yes is a likely target of male contraceptive research.testis; c-Yes; nonreceptor protein tyrosine kinase; Sertoli cell; spermatogenesis; seminiferous epithelial cycle; ectoplasmic specialization DURING SPERMATOGENESIS, EXTENSIVE RESTRUCTURING and communication take place at the Sertoli cell-cell and Sertoli-germ cell interface across the seminiferous epithelium to accommodate germ cell movement and to coordinate cellular events that occur simultaneously at different stages of the seminiferous epithelial cycle in the mammalian testis (12,23,48). For instance, at stage VIII of the epithelial cycle, preleptotene spermatocytes, differentiated from type B spermatogonia, residing in the basal compartment traverse the blood-testis barrier (BTB) to enter the adluminal compartment while transforming to leptotene and zygote spermatocytes to prepare for meiosis I/II (23, 48). However, fully developed spermatids that become spermatozoa at the adluminal edge of the tubule lumen undergo spermiation; the release of sperm also takes place at stage VIII of the cycle, involving degeneration of the apical ectoplasmic specialization (apical ES) at the Sertoli-spermatid

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Elevated c-Src and c-Yes expression in malignant skin cancers

Cited by 39 publications

References 14 publications

Comprehensive characterization of glioblastoma tumor tissues for biomarker identification using mass spectrometry-based label-free quantitative proteomics

Comprehensive characterization of glioblastoma tumor tissues for biomarker identification using mass spectrometry-based label-free quantitative proteomics

αE-catenin inhibits a Src–YAP1 oncogenic module that couples tyrosine kinases and the effector of Hippo signaling pathway

c-Yes regulates cell adhesion at the apical ectoplasmic specialization-blood-testis barrier axis via its effects on protein recruitment and distribution

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