Elevated Brain-Derived Neurotrophic Factor Levels During Depressive Mixed States
Naoaki Otsuka,
Yoshikazu Takaesu,
Yu Zamami
et al.
Abstract:Objective Neurotrophin-like brain-derived neurotrophic factor (BDNF) and pro-inflammatory cytokines may modulate the pathophysiology of mood disorders. Although several studies show alterations in these biomarkers during the depressive, manic, and euthymic states of mood disorders, evidence is lacking for those in a mixed state. Therefore, this study aimed to investigate the relationship between the depressive mixed state (DMX) and peripheral neurobiological factors.Methods We enrolled 136 patients with major … Show more
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